Devices, compositions, and methods for use in surface decontamination

ABSTRACT

Provided are devices, compositions, and methods for surface disinfection and decontamination; the devices generally adapted to contain a single or multi-component indicator composition, and optionally a disinfectant composition, and to dispense the indicator composition and optional disinfectant composition to a disinfectant solution, a surface, or a disinfectant article upon actuation of the device; also provided is an article of manufacture in the form of a removable cartridge adapted to fit a device described here, which may be pre-filled with a single or multi-component indicator composition as described here, and/or with a disinfectant composition, and one or more optional additives.

RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No.17/257,997, filed Jan. 5, 2021, which is a U.S. National stage entry ofInternational Application No. PCT/US2019/041604, which designated theUnited States and was filed on Jul. 12, 2019, published in English,which claims the benefit of U.S. Provisional Application No. 62/697,278,filed on Jul. 12, 2018 and U.S. Provisional Application No. 62/799,459,filed on Jan. 31, 2019. The entire teachings of the above applicationsare incorporated herein by reference.

TECHNICAL FIELD

The subject matter described herein generally relates to devices,indicator compositions, and methods for use in surface decontamination,specifically, in dispensing, monitoring, visualizing, and controllingapplication of indicator compositions to wipes, such as disinfectantwipes for surface decontamination.

BACKGROUND

A recent report published in JAMA Internal Medicine found thatcontamination of skin and clothing occurs during glove and gown removalin 60% of cases (ME Tomas, et al. (2015). Contamination of Health CarePersonnel During Removal of Personal Protective Equipment. JAMA InternMed. 175(12):1904-10.) When using educational intervention and visualfeedback, the study found that the rate of contamination fell to 18.9%.However, providing training on proper personal protective equipmentremoval is not always feasible, especially in resource-limited settingsor during epidemics, and many commonly used disinfectants do not providevisual feedback. Thus, there exists a need for improved compositions,methods and techniques to ensure proper disinfection of a variety ofsurfaces to reduce the rate of contamination.

Commercially available products such as Glo Germ™ have demonstrated theimportance of visualizing disinfection. For instance, Glo Germ™ has beenused in the Mount Sinai Health System to ensure that surfaces arecompletely disinfected (The Wall Street Journal, (2015 Nov. 2)).However, Glo Germ™ requires the use of an ultraviolet light forvisualization, which may not be readily available in the field, andrequires a power source. In addition, the need to apply Glo Germ™ beforeevery disinfection and to carry around or install an ultraviolet lightsource can be tedious and infeasible for checking all disinfectedsurfaces in a fast-paced hospital setting.

Further studies have also demonstrated that improving compliance withdecontamination protocols, include waiting sufficient contact time for adisinfectant to inactivate a pathogen can reduce the rate ofhospital-acquired infections by more than 80% (R Orenstein, et al.(2011). Infect Control Hosp. Epidemiol. 32(11):1137-9.) This stronglysuggests that a method for improving compliance with contact time isurgently needed to reduce the rate of infection in hospitals, as well asfor consumer use.

There remains a need for new devices, compositions, and methods toensure the thorough and efficient disinfection of surfaces. The presentinvention addresses this need.

SUMMARY OF THE INVENTION

In an aspect, described is a device for applying a composition to a wipedispensed through the device. The device includes a housing at leastpartially surrounding an interior volume. An exterior wall of thehousing defines a dispensing aperture extending through the exteriorwall. A lower end region of the housing includes an opening throughwhich at least one wipe of a plurality of wipes is drawn into theinterior volume of the housing from a canister holding the plurality ofwipes. One or more connecting features are on the lower end region ofthe housing. The device includes a dispensing mechanism positionedwithin the interior volume of the housing. The dispensing mechanismincludes a plurality of rollers configured to capture and direct the atleast one wipe through the interior volume of the housing towards thedispensing aperture. The device includes an application mechanismpositioned within the interior volume of the housing relative to thedispensing aperture. The device includes a processor in operativecommunication with a sensor and an input. The sensor is configured tocommunicate to the processor information related to the at least onewipe directed towards the dispensing aperture.

The processor can be configured to monitor, analyze, and record in amemory of the device the information. The processor can be configured tocontrol automatically at least one function of the device based on theinformation. The information communicated from the sensor to theprocessor can be synchronized with a time log. The informationsynchronized with the time log can indicate productivity of a userand/or activity of the device. The information communicated from thesensor to the processor can be analyzed by software program running onthe processor. The information communicated from the sensor can indicatea number of the plurality of wipes dispensed through the dispensingaperture. The number of the plurality of wipes dispensed can be based onan amount time spent actuating the input of the device. The number ofthe plurality of wipes dispensed can be based on a number of revolutionsmade by the plurality of rollers. The number of the plurality of wipesdispensed can be based on perforations between each of the plurality ofwipes dispensed detected by the sensor. The number of the plurality ofwipes dispensed can be synchronized with a time log. The informationcommunicated from the sensor to the processor can indicate timingbetween when a first wipe of the plurality of wipes is dispensed and asecond wipe of the plurality of wipes is dispensed. The informationcommunicated from the sensor to the processor can indicate a frequencyof wipes dispensed over time. The information communicated from thesensor to the processor can indicate when multiple wipes are dispensedsimultaneously.

The sensor can be an optical sensor or a mechanical sensor. Theinformation communicated can be a presence of the at least one wipe ofthe plurality of wipes within the dispensing aperture. At least aportion of the at least one wipe can interface with the sensor. Thedevice can further include a movable, mechanical cover located relativeto the dispensing aperture that is configured to interface with thesensor. The information communicated by the sensor can be displacementof the cover relative to the dispensing aperture. The processor can beprogrammed to inactivate one or both of the application mechanism andthe dispensing mechanism based on the information communicated from thesensor. The information communicated from the sensor can indicate thecover is displaced and has not moved for a period of time.

The processor can be programmed to cause the plurality of rollers toautomatically withdraw the at least one wipe of the plurality of wipesaway from the dispensing aperture after the period of time. The periodof time can be between 10 seconds and 30 seconds, between 30 seconds and1 minute, between 1 minute and 2 minutes, between 1 minute and 5minutes, or between 1 minute to about 20 minutes, or between 1 minute toabout 60 minutes.

The device can further include a user interface and the period of timecan be programmable by a user on the user interface. The sensor caninclude a first sensor configured to interface with the at least onewipe of the plurality of wipes within the dispensing aperture. Thedevice can further include a second sensor configured to interface witha movable, mechanical cover located relative to the dispensing aperture.

The exterior wall of the housing can form an upper surface of the deviceor a side surface of the device. The lower end region of the housing canbe sized to couple to the canister holding the plurality of wipes. Theone or more connecting features on the lower end region can beconfigured to removably couple the lower end region to the canister.When the device is coupled to the canister, an interior of the canistercan be in fluid communication with the interior volume of the housingthrough the opening. The device can form a removable lid for thecanister.

The device can further include an adapter having a first lip on an upperregion of the adapter and a second lip on a lower region of the adapter.The first lip can be sized to reversibly couple to the lower end regionof the housing and the second lip can be sized to reversibly couple tothe canister. The one or more connecting features on the lower endregion of the housing can be configured to removably couple the lowerend region of the housing to an adapter. The adapter can include asensor configured to interface with one or both of the device and thecanister. The sensor of the device can be configured to interface with acorresponding element on the canister holding the plurality of wipes.The sensor of the device can be a mechanical sensor or an opticalsensor. The corresponding feature on the canister can be a tactileseries of ridges and bumps forming a code configured to be detected bythe sensor. The code can provide information about the plurality ofwipes contained within the canister. The code can delineate one or bothof a chemistry of the plurality of wipes and wipe dimension.

The device can further include a removable cartridge configured to becoupled to the housing. The cartridge can include a cartridge housingdefining a reservoir; and a penetrable barrier extending through aportion of the housing. The cartridge can include a sensor configured todetect liquid volume within the reservoir of the cartridge. The sensorof the cartridge can be an optical sensor or a mechanical sensor. Thereservoir can be refillable. The reservoir can include two or morechambers sized to contain two or more separate compositions in eachchamber. For example, the reservoir may contain 2, 3, 4 or more chambersadapted to contain 2, 3, 4, or more separate compositions that areseparate components of a multi-component composition described infra. Insome implementations, the reservoir can include a first chamber sized tocontain a first composition and a second chamber sized to contain asecond composition separate from the first composition. In someimplementations, the reservoir can include a first chamber sized tocontain a first composition, a second chamber sized to contain a secondcomposition separate from the first composition, a third chamber sizedto contain a third composition separate from the first two compositions,and optionally a fourth chamber sized to contain a fourth compositionseparate from the first three compositions. In some implementations, thereservoir can include more than 4 chambers. The application mechanismcan be configured to apply each of the separate compositions to the atleast one of the plurality of wipes. For example, in someimplementations, the application mechanism can be configured to applythe first and second composition to the at least one of the plurality ofwipes; or the application mechanism can be configured to apply thefirst, second, and third, or optionally fourth composition to the atleast one of the plurality of wipes, and so on, where there are morethan 4 separate compositions. It should be understood that the separatecompositions are components of a multi-component indicator compositiondescribed here, in which each component is kept separate from the othersuntil they are combined, e.g., at the point of use. In someimplementations, the application mechanism is configured to apply eachof the separate compositions to an article or surface simultaneously. Insome implementations, a single application mechanism is configured toapply each of the separate compositions; in some implementations, two ormore of the separate compositions are applied by different applicators.For example, the application mechanism can be configured to apply thefirst and second compositions simultaneously, or to apply the first,second, and third compositions simultaneously, and so on, for four ormore compositions. The application mechanism can also include a firstapplicator for the first composition and a second applicator for thesecond composition, or three applicators for the first, second, andthird compositions, etc. In some implementations where the applicationmechanism comprises two applicators, the first and second applicatorscan be arranged to dispense in parallel, in series, or in combination.

In some implementations, the multi-component indicator compositioncomprises at least two components contained in separate chambers of acartridge, or two separate cartridges. In some implementations, thefirst component of the composition comprises a colorant and optionallyan acidic agent or acidifying agent, and/or a corrosion inhibitor; andthe second component comprises a disinfectant composition and optionallyone or more surfactants and/or a rheology modifier. In someimplementations, the colorant is selected from any of a triarylmethane,azo, indigoid, or acid dye, preferably selected from indigo carmine,Acid Blue 1, Direct Blue 1, or FD&C Blue 1; the optional acidic agent oracidifying agent is selected from citric acid, benzoic acid, aceticacid, hydrochloric acid, sulfuric acid, nitric acid, hydrofluoric acid,hydrobromic acid, perchloric acid, chloric acid, hydroiodic acid,sulfurous acid, methanoic acid, phosphoric acid, nitrous acid,benzenesulfonic acid, metaperiodic acid, ascorbic acid,trimethoxybenzoic acid, peracetic acid, oxalic acid, formic acid,glucaric acid, gluconic acid, tartaric acid, lactic acid, boric acid,carbonic acid, acrylic acid, phenylsuccinic acid, succinic acid,propanoic acid, and acidic buffers within the range of pH 0-7 comprisedof acids and their necessary conjugate bases as well as optionalstabilizing salts; and the optional corrosion inhibitor is sodiumcarbonate; and in the second composition, the disinfectant is ahypochlorite based disinfectant and the surfactant, if present,comprises one or more of sodium xylene sulfonate, disodium decyl phenylether disulfonate, and disodium oxybis[decylbenzenesulfonate].

In some implementations, the application mechanism can include at leastone applicator; and a transfer element including a pump. The transferelement can transfer the amount of the first and second compositionsfrom the reservoir towards the at least one applicator. The transferelement can create a pressure differential relative to an interior ofthe reservoir to transfer the amount. The input can be an actuatorconfigured to simultaneously activate the pump of the dispensingmechanism and the application mechanism. The dispensing mechanism canfurther include a motor. The actuator can activate the motor. The devicecan further include a removable cover positioned over the dispensingaperture. The actuator can open the cover exposing the dispensingaperture. The device can further include one or more grippers configuredto engage the wipes during dispensing. The actuator can activate the oneor more grippers. The actuator can activate one or more of the transferelement, the at least one applicator, the motor, the cover, and thegrippers simultaneously. The pump of the transfer element can be poweredby an electric motor upon actuation of the input to create a pressuredifferential relative to the interior volume of the reservoir. The pumpcan be a positive displacement pump, reciprocating pump, rotary pump,piston pump, diaphragm pump, peristaltic pump, dynamic pump, centrifugalpump, or hydraulic pump. The at least one applicator can be configuredto apply the amount of first and second composition to the wipe bydirectly contacting the wipe. The application mechanism can provide forone-sided or two-sided application of the amount of the first and secondcomposition to the wipe.

BRIEF DESCRIPTION OF THE FIGURES

These and other aspects will now be described in detail with referenceto the following drawings. Generally speaking, the figures are not toscale in absolute terms or comparatively, but are intended to beillustrative. Also, relative placement of features and elements may bemodified for the purpose of illustrative clarity.

FIG. 1A is a schematic of an implementation of a device configured toapply an indicator solution to a wipe;

FIG. 1B is a box diagram showing an implementation of a device havingcomputer system;

FIG. 2 is a schematic showing a device in communication with a remotecomputing device;

FIG. 3 is a schematic illustrating a plurality of devices incommunication with a remote computing device and with one another;

FIG. 4A is a perspective view of an implementation of a deviceconfigured to apply an indicator solution to a wipe;

FIG. 4B is a perspective view of the device of FIG. 4A exposing aninterior of the device housing;

FIG. 4C is an exploded, partial perspective view of the device of FIG.4A;

FIG. 4D is a side view of the device of FIG. 4A showing the housing inan articulated position;

FIG. 4E is a perspective view of the device of FIG. 4A;

FIG. 4F is a partially exploded view of the device of FIG. 4E with acartridge removed from the housing;

FIG. 4G is a perspective view of the device of FIG. 4A in which thehousing is transparent;

FIG. 4H is an exploded view of the device of FIG. 4A;

FIGS. 4I-4K are cross-sectional views of the device of FIG. 4A;

FIGS. 5A-5B are various views of a dispensing aperture in a cap of thedevice of FIG. 4A;

FIGS. 6A-6B are perspective views of a cartridge of the device of FIG.4A;

FIGS. 7A-7C are various views of a pneumatic tap of the device of FIG.4A;

FIGS. 8A-8B are perspective and cross-sectional views, respectively, ofthe pumping element of the device of FIG. 4A;

FIG. 9 is a schematic of the fluid flow through the device of FIG. 4A;

FIG. 10 is a perspective view of a pair of applicators of the device ofFIG. 4A;

FIG. 11A is a perspective view of another implementation of a deviceconfigured to apply an indicator solution to a wipe;

FIG. 11B is a perspective view of the device of FIG. 11A;

FIG. 11C is a side, cut-away view of the device of FIG. 11A;

FIG. 11D is a side, cut-away view of the device of FIG. 11A showing thepath of a wipe through the interior;

FIG. 11E is a side, cut-away view of the device of FIG. 11Aincorporating an alternative actuator;

FIG. 11F is a perspective, partial view of the device of FIG. 11A;

FIG. 11G is a perspective, partial view of the device of FIG. 11A;

FIG. 12A is a perspective view of an implementation of a deviceconfigured to apply an indicator solution to a wipe;

FIG. 12B is a front view of the device of FIG. 12A;

FIG. 12C is a side view of the device of FIG. 12A;

FIG. 12D is a bottom view of the device of FIG. 12A;

FIG. 12E is a back inside view of the device of FIG. 12A;

FIG. 12F is a side inside view of the device of FIG. 12A;

FIG. 12G is a vertical, cross-sectional view of the device of FIG. 12A;

FIG. 12H is a top view of the device of FIG. 12A without a cartridgeinstalled.

FIG. 12I is a partial cross sectional view of the device of FIG. 12Hwith a cartridge installed.

FIG. 13A-C shows top (A), side (B), and perspective (C) views of anadapter for the lid device.

FIG. 14A-14C shows top (A), side (B), and perspective (C) views of anadapter for the lid device having a sensor.

FIG. 15 shows a bottom view of a device having a sensor positioned neara lower end region.

Generally speaking, the figures are not to scale in absolute terms orcomparatively but are intended to be illustrative. Also, relativeplacement of features and elements may be modified for the purpose ofillustrative clarity.

DETAILED DESCRIPTION

The present disclosure provides devices, compositions, and methods forsurface disinfection and decontamination. The devices described here aregenerally adapted to contain a single or multi-component indicatorcomposition, and optionally including a disinfectant composition, and todispense the indicator composition and optional disinfectant compositionto a disinfectant solution, a surface, or a disinfectant article uponactuation of the device. In some implementations, the disclosureprovides an article of manufacture in the form of a removable cartridgeadapted to fit a device described here, which may be pre-filled with asingle or multi-component indicator composition as described here, andoptionally with a disinfectant composition. As discussed infra, in someimplementations the cartridge comprises two or more chambers adapted tokeep the contents of the chambers separate until the device is actuated.In some implementations, the disinfectant composition is separate fromthe one or more components of a single or multi-component indicatorcomposition, for example the disinfectant composition is contained in aseparate chamber of a multi-chambered cartridge from the indicatorcomposition, or components thereof. In some implementations, thedisinfectant composition and one or more of the components of amulti-component indicator composition may be combined, for example inthe same chamber of a multi-chambered cartridge with at least one of thecomponents of the multi-component indicator composition.

In some implementations, the device takes the form of an adjustable andremovable lid adapted to fit a canister containing a disinfectantsolution or article such as a woven or non-woven fabric or sponge, whichmay optionally be in the form of a continuous sheet optionallyperforated for ease of separation into smaller sheets, e.g., in the formof perforated cloths, towels, or wipes. In the context of the presentdisclosure, the article may also be referred to simply as a “wipe,”which is understood to be a general term for an article that may takeany of a variety of forms, including that of a cloth, pad, towel, ortowelette, and which may be comprised of any of a variety of materialsincluding a woven or non-woven fabric, sponge, gauze, cellulose, orpolypropylene material. In some implementations, the device is adaptedto dispense the indicator composition into a disinfectant solutioncontained in the canister, or onto at least one article of a pluralityof articles contained in the canister.

The compositions described here are adapted to impart a visible color toa disinfectant composition, for example a hypochlorite baseddisinfectant, a hypochlorous acid based disinfectant, adichloroisocyanurate based disinfectant, such as sodiumdichloroisocyanurate, a quaternary ammonium based disinfectant, aquaternary ammonium/alcohol based disinfectant, an alcohol baseddisinfectant, an acid/alkali based disinfectant, a heavy metal baseddisinfectant, an aldehyde based disinfectant, a peroxide baseddisinfectant, for example a hydrogen peroxide based disinfectant, or aperacetic acid based disinfectant, which color fades to clear afterapplication of the colored disinfectant to a surface, thereby providingan indication of both surface coverage and time of contact with thesurface which together provide an indication of adequate decontaminationand/or disinfection of the surface. Accordingly, the compositionsdescribed here are generally referred to as ‘indicator compositions’. Insome implementations, the disinfectant composition is an aqueoussolution comprising a disinfectant selected from sodium hypochlorite,sodium dichloroisocyanurate, potassium dichloroisocyanurate,hypochlorous acid, hydrogen peroxide, ethyl alcohol, a quaternaryammonium compound, a mixture of a quaternary ammonium compounds, amixture of a quaternary ammonium compound(s) and an alcohol(s), analcohol, peracetic acid, accelerated hydrogen peroxide, chlorinedioxide, calcium hypochlorite, chlorhexidine gluconate, glutaraldehyde,formaldehyde, and phenol. In some implementations, the disinfectantcomposition may comprise aldehydes (e.g., formaldehyde, glutaraldehye,and ortho-phthalaldehyde), hydrogen peroxide-peracetic acidcombinations, iodophors, and phenols or phenolics.

In some implementations, an indicator composition according to thedisclosure is a single component composition, or alternatively, isformed from the combination of two or more separate components which arekept physically separated prior to use, optionally within a container orreservoir having a plurality of separate compartments and adapted to fitwithin a device, for example in the form of an integral or removablecartridge, as described herein. In some implementations, a device asdescribed herein may accommodate two or more cartridges, each adapted tocontain a single composition, or one or more components of amulti-component composition described here.

In some implementations, an indicator composition is provided along witha disinfectant composition in a device adapted to combine the indicatorcomposition(s) and the disinfectant composition at the point of use, forexample upon actuation of the device. The indicator composition may be asingle or multi-component composition. Where the indicator compositionis a multi-component composition, it may be provided in an article ofmanufacture, such as a removable cartridge, adapted to fit removablywithin a device configured to mix the several components of themulti-component composition upon actuation of the device, therebyforming a single component indicator composition at the point of use.The device may also be adapted to dispense the resulting singlecomponent indicator composition onto a surface or article, or into adisinfectant composition, such as a hypochlorite based disinfectant, aquaternary ammonium or alcohol based disinfectant, a hydrogen peroxidebased disinfectant, or a peracetic acid based disinfectant. In someimplementations, the device is adapted to dispense the single ormulti-component indicator composition along with a disinfectantcomposition which may be dispensed from a further compartment orreservoir of the device, or which may be dispensed through anothermechanism, onto the surface or article.

In some implementations, the device is configured to apply a single ormulti-component indicator composition as described herein onto anarticle, such as a woven or non-woven fabric or sponge article, wherethe article is optionally dry or pre-saturated with a disinfectantcomposition. In some implementations, the single or multi-componentindicator composition is applied to the disinfectant composition orarticle upon actuation of a device containing the indicator composition,and optionally also containing the disinfectant composition. Forexample, where a woven or non-woven fabric or sponge article, such as awipe, is housed within a container, a device as described here isadapted to couple securely to the open top of the container andconfigured to permit threading of the article into the device in amanner that brings the article into proximity with a means fordispensing the single or multi-component indicator composition, andoptionally a disinfectant composition, onto the article and thendispensing the article through an opening of the device for use inapplication to a surface.

The single and multi-component indicator compositions described herecontain a colorant, generally in the form of a water soluble dye or lakepigment, a catalyst which modulates the transition of the colorant froma visible color to colorless, and one or more optional additives. Inthis context, the term ‘catalyst’ is used to refer to an agent thatdirectly or indirectly modulates the loss of color from the colorant, orthe ‘fade time’ of the colored disinfectant composition followingaddition of the indicator composition thereto, meaning the time requiredfor the colored disinfectant composition to fade to clear, for exampleafter application to a surface. In some implementations, the catalystmay be provided by the disinfectant composition itself. In someimplementations, the catalyst is a component of the indicatorcomposition. The colorants and catalysts which may be used in thepresent compositions are described in more detail in the “Compositionsand Methods” section below.

In some implementations, the colorant of the indicator composition doesnot include fluorescent substances and instead includes only substancesthat impart color by the selective absorption or scattering of light. Insome implementations, the colorant is a water soluble oxidizable dye orpigment. In some implementations, the colorant is not a pH sensitive dyeor pigment. In some implementations, a single or multi-componentindicator composition as described here does not contain a pH sensitivedye or an alkaline builder in combination.

In some implementations the one or more optional additives is selectedfrom one or more of a pH modulator such as an acidic agent, an alkalinebuilder or base, or a suitable buffer system adapted to maintain adesired pH, a surfactant, a corrosion inhibitor, a perfume or fragrance,which may be an oil, a humectant, and a rheology modifier. In someimplementations the one or more additional additives serves to improvethe aesthetics of the composition, for example, a perfume, fragrance, orhumectant, or to enhance the disinfectant and/or decontaminationproperties of the composition, including for example, one or more of apH modulator, a surfactant or combination of surfactants, a corrosioninhibitor, and a rheology modifier. The optional additives which may beused in the present compositions are described in more detail in the“Compositions and Methods” section below.

The indicator compositions described here can be formulated as a liquid,gel, or powder.

In some implementations, a multi-component indicator composition asdescribed here may also further comprise a disinfectant composition. Insome implementations, the colorant of a multi-component indicatorcomposition comprising a disinfectant composition is not a pH sensitivedye and the composition does not comprise an alkaline builder.

In some implementations, the indicator composition and the disinfectantcomposition are contained in at least two separate compartments formedby at least one interior wall of a container or reservoir and adapted tofit within a device as described herein, for example in the form of aremovable cartridge.

In some implementations, the disinfectant composition may be pre-appliedto an article, such as a wipe or cloth, or the article may be saturatedwith the disinfectant composition, or the disinfectant composition maybe pre-applied to a surface, for example by wiping or spraying onto asurface, before addition of an indicator composition of the presentdisclosure; or the disinfectant solution and the indicator solution maybe mixed together before application to the article or surface.

In accordance with any of the implementations described here, thedisinfectant composition may be selected from an aqueous or non-aqueoussolution of sodium hypochlorite, calcium hypochlorite, sodiumdichloroisocyanurate, didecyldimethylammonium chloride, chlorhexidinegluconate, a phenol, an aldehyde, a terpene, hydrogen peroxide, chlorinedioxide, peroxy and peroxo acids such as peracetic acid, quaternaryammonium compounds, inorganic compounds such as metals and acids, andalcohols such as ethanol and isopropyl alcohol. In some implementations,the disinfectant composition is selected from an aqueous solution ofhypochlorite, dichloroisocyanurate, hydrogen peroxide, peracetic acid, aquaternary ammonium compound (including mixtures of quaternary ammoniumcompounds and mixtures with alcohol), and an alcohol.

In the context of the present disclosure, the term “about” in referenceto a numerical value is meant to encompass variations of +/−25%,preferably +/−15% or +/−10% from the stated value.

Devices

FIG. 1A is a schematic of an implementation of a device configured toapply one or more fluid compositions to a wipe as the wipe is dispensedfrom its canister. In some implementations, the fluid compositioncomprises an indicator composition and/or a disinfectant composition asdescribed herein. However, other fluid compositions may also be appliedand the device is not limited by the nature of the fluid composition,which may comprise, for example, an all-purpose cleaner, soap,detergent, metal cleaner, window cleaner, hand-surface cleaner, paint,primer, polish, lotion, etc. It should also be appreciated that theenvironment in which the devices and compositions described herein canvary and may include the home, food business, hospital, nursing or othercare facility, etc.

The device 400 can include a housing 412 having a dispensing aperture416 and an application mechanism 418 configured to be in fluidcommunication with a reservoir 414. The application mechanism 418 can bea direct contact type application mechanism or a non-contact applicationmechanism, which will be described in more detail below. The device 400can optionally include a dispensing mechanism 430 configured to dispensethe wipes W from the canister C. Each of the components will bedescribed in more detail below.

Again with respect to FIG. 1A and as also shown in FIGS. 4A-4M, FIGS.11A-11G, and FIGS. 12A-12I, the housing 412 can at least partiallysurround an interior volume 425 and have a wall defining the dispensingaperture 416 extending through a wall of the housing 412. The locationof the dispensing aperture 416 can vary. For example, the dispensingaperture 416 can extend through an upper surface 419 or a side surface421 of the housing 412 near an upper end region 417 of the housing 412.A lower end region 423 of the housing 412 can define an internalaperture or opening 415 such that when the housing 412 is coupled to aregion of the canister C of wipes W, such as an upper end of thecanister C, the wipe W stored within the interior of the canister C canbe drawn into the interior 425 of the housing 412 through the opening415. When the device 400 is coupled to the canister C of wipes W, aninterior of the canister C can communicate with or be placed incommunication with the interior 425 of the housing 412 through theopening 415. The wipe W stored within the interior of the canister C canenter the interior 425 of the housing 412 from the lower end region 423through the opening 415 and fed towards the dispensing aperture 416 inthe upper end region 417. The dispensing aperture 416 need not be in theupper end region 417 and can also be found near a lower end region 423of the housing.

The dispensing aperture 416 can be configured to allow single ormultiple wipes W to be dispensed through it. The dispensing aperture 416can be a slit having a rectangular, cross, x, flower petal, or zig-zagshape. The size and shape of the dispensing aperture 416 can varydepending on whether the device 400 is configured for manual dispensingor automatic dispensing. For example, the device 400 can optionallyinclude a dispensing mechanism 430 that is an automatic dispensingmechanism or manual. The dispensing mechanism 430 can be configured toarrange the wipe W in a manner that encourages uniform application ofthe composition to the wipe W as the wipe W is fed through the interior425 of the housing 412 towards the dispensing aperture 416. Thedispensing aperture 416 for the automatic dispensing mechanism 430 canbe a rectangular-shaped dispensing aperture 416 whereas the manuallydispensed configuration may incorporate a zig-zag shaped dispensingaperture 416. The size and shape of the dispensing aperture 416 can beselected to assist in separating the wipes W from one another. Wipes Wcan be packaged such that they are stacked in interlocking folds or arearranged such that each sheet is connected to the other and separated byperforations. Depending on the overall configuration of the dispensingaperture 416, a plurality of flaps can be formed that are configured tocompress the wipe W as it extends through the dispensing aperture 416.This can provide more or less volume of a liquid composition, such as anindicator composition and/or a disinfectant composition describedherein, or other composition as described above, to be applied to thewipe W, or leave more or less volume of the composition impregnated onwipe W, as it is dispensed. The larger the space between the flaps ofthe dispensing aperture 416 the greater the volume of the compositionmaintained on the wipe W and vice versa.

The device 400 can optionally include a mechanism that aids inseparating sheets of wipes W from one another. For example, a pinchermechanism can be included that pivots towards the wipes W as they extendthrough the interior of the device 400 to capture the sheets of wipes Wand allow for easier separation. In some implementations, the wipe W isdispensed through the device 400 manually such as by a user pulling thewipe W through the dispensing aperture 416 (e.g. through a top surface419 or a side surface 421). In some implementations, the wipe W isdispensed through the device 400 by a dispensing mechanism 430 that isan automatic feed system including a powered motor. Regardless of themechanism by which the wipe W is dispensed through the device 400, thewipe W that is dispensed has a composition applied, for example anindicator composition and/or a disinfectant composition describedherein, or other composition as described above.

In some implementations, the dispensing aperture 416 extends through acap 485 movably coupled to an upper surface 419 of the housing 412 (seeFIG. 4B and also FIGS. 5A-5B). The upper surface 419 of the housing 412can define an opening 487 that is covered by the cap 485. The cap 485can be coupled to the upper surface 419 of the housing 412 by a hinge489 such that the cap 485 can be opened revealing an interior 425 of thehousing 412 through the opening 487. The cap 485 can also include alocking element 490 having a latch 492 that can be toggled between alocked configuration keeping the cap 485 in the closed position over theopening 487 and unlocked configuration allowing the cap 485 to hingeopen revealing the interior 425 through the opening 487. Opening the cap485 can be helpful, for example, to thread the first wipe W into thedevice 400. The cap 485 can additionally include a cover 494 over thedispensing aperture 416 to avoid inadvertent drying out of the wipes Win their canister C. The cover 494 can be hinged such that the cover 494can be manually or mechanically opened. For example, the cover 494 caninclude a spring-loaded hinge that opens when an actuator is pushed. Insome implementations, the actuator 431 can simultaneously release thecover 494, activate the transfer element 427 to pump a fluid compositiontowards the applicator 429, and activate the applicator 429 to apply thetransferred composition to the wipe W. The actuator 431 can alsosimultaneously activate any gripper, pincher elements so that the fluidsaturated wipe W is released and ready for use. The cover 494 can alsoautomatically close (and the gripper automatically released) when theactuator 431 is released to prevent the wipes W within the canister Cfrom drying out. Consolidating the various mechanisms into a singleactuation simplifies use of the device 400 such that it can be used witha single hand. It should be appreciated, however, that the variouscomponents can also include their own actuator and/or be configured formanual use.

The lower end region 423 of the housing 412 can incorporate one or moreconnecting features 426 configured to removably or detachably couple thedevice 400 to the canister C of wipes W. The connecting feature 426 caninclude a thread corresponding to a thread of the canister C, a snap-fitconnection, fitting, fastener, or coupling feature sized to fit a regionof the canister C. In some implementations, the device 400 is configuredto connect to the canister C such that the device 400 functions as a lidon an open end of the canister C. The device 400 can be used to replacean existing lid on the canister C. As such, the connecting feature 426can be designed according to dimensional standards for containerclosures. The connecting feature 426 also can be adjustable such that itcan fit variable sizes of canisters. In other implementations, thedevice 400 is configured to connect to the canister C already enclosedwith a lid having a dispensing aperture. In this implementation, thedevice 400 can function as an auxiliary attachment to the alreadyenclosed canister C. The device 400 need not be removable from thecanister C and can be a single-use device affixed to a canister C ofwipes W. The connecting feature 426 can include a bottom ring 433 sizedto surround and engage with an upper rim of the canister C of the wipesW (see FIG. 4D). The bottom ring 433 can include one or more grooves,threads, snap-fit feature, or other coupling features that allows thedevice 400 to be attached to the canister C. In some implementations,the bottom ring 433 is a universal coupler that allows it to be attachedto canisters C of various sizes. The bottom ring 433 can incorporate adrain hole 428 (see FIG. 12D) that allows for any excess liquid from thedispensed wipe W to drain back into the canister C.

Still with respect to FIG. 4D, the bottom ring 433 can be coupled by ahinge element 435 to an upper plate 436 affixed to a lower end region423 of the housing 412. The upper plate 436 defines the internal opening415 through which the wipe W extends into the interior 425 of the device400. A release button 445 can be incorporated that when actuatedreleases a latch 446 engaging the bottom ring 433. Actuation of therelease button 445 moves the latch 446 thereby releasing engagementbetween the lower end region 423 of the housing 412 and the bottom ring433. This allows the housing 412 to be opened and hinge relative to thebottom ring 433 when the device 400 is coupled to a canister C. Thisexposes the upper end of the canister C through the aperture 415 withoutremoving the entire device 400 from the canister C. Hinging the device400 into an opened position in this way may be helpful when a user needsto assist with priming the lead or first wipe W into the device 400,which will be described in more detail below. In some implementations,the hinge 435 can include stoppers to limit the angle at which the lidcan be opened. The hinge stopper can prevent the container from tippingbackwards upon articulating the upper portion relative to the lowerportion of the device 400.

FIGS. 12A-12I illustrate an implementation of the device 400 having apair of release buttons 445 positioned on either side of the housing412. The pair of buttons 445 can be squeezed by a single hand toward oneanother to release and open the housing 412 to expose the upper end ofthe canister C through the aperture 415. Additionally, upon hinging openthe housing 412, the upper portion can include a sealed gasket or otherelement to enclose the components of the housing 412. The gasket canminimize noise of the components as well as providing better aestheticsand protection for the components. Additionally, one or more of themoving parts within the housing 412 (e.g. motor, gearbox, pumpingelement) can be in a sealed enclosure or encased to maintain a quieterfunctioning device that is more robust.

The reservoir 414 (which can be a removable reservoir) can have at leastone reservoir chamber sized to contain an amount of a composition, forexample an indicator composition and/or a disinfectant compositiondescribed herein, or other composition as described above. The devicecan include more than one reservoir 414 or a single reservoir 414divided into two or more separate chambers sized to hold volumes ofdifferent compositions. The volume of the reservoir 414 can besufficient to dispense enough of a composition for the number of wipesin the bucket the lid fits onto. In embodiments where the deviceincludes at least two reservoirs 414 or a single reservoir 414 dividedinto at least two separate chambers, the different compositions mayinclude, for example, two solutions which, when applied to the wipe byactuation of the device, form an indicator composition in situ, on thewipe. Examples of two-part and multi-part indicator compositions aredescribed in more detail below. In other embodiments, the differentcompositions which are held either in two or more reservoirs 414 or in asingle reservoir 414 divided into at least two separate chambers mayinclude an indicator composition and another composition, such as adisinfectant composition, which are both applied simultaneously to thewipe by actuation of the device. The disinfectant composition ispreferably a solution comprising a suitable amount of a disinfectantmaterial selected from an aqueous or non-aqueous solution of sodiumhypochlorite, calcium hypochlorite, sodium dichloroisocyanurate,didecyldimethylammonium chloride, chlorhexidine gluconate, a phenol, analdehyde, a terpene, hydrogen peroxide, chlorine dioxide, a peroxy andperoxo acid such as peracetic acid, a quaternary ammonium compound, aninorganic compound such as metals and acids, and alcohols such asethanol and isopropyl alcohol.

In embodiments, the amount of composition applied to the wipe is in therange of from 0.0001-0.1 ml per square centimeter (cm²) of the wipe,preferably from 0.001-0.05 ml/cm² of wipe. Accordingly, where thereservoir is referred to herein as a single reservoir it should beappreciated that the reservoir can be configured to hold a sufficientamount of a composition for application to a plurality of wipes.

The reservoir 414 can be located at least partially within the housing412. The reservoir 414 can be refillable and/or removable from thehousing 412. In some implementations, the reservoir 414 can be containedwithin a cartridge 413 having a housing configured to removably coupleto a region of the housing 412, which will be described in more detailbelow. As best shown in FIGS. 4E-4F and also FIGS. 6A-6B, the cartridge413 is configured to removably couple with a region of the housing 412.In some implementations, the housing 412 can include a receptacle regionsuch as a slot 437 sized and shaped to receive at least a portion of thecartridge 413. The cartridge 413 can slide with the slot 437 from thetop surface 419 of the housing 412 such that a coupling feature 439 ofthe cartridge 413 engages with a corresponding coupling feature 441within the slot 437 of the housing 412. Engagement between the couplingfeatures 439, 441 can result in the interior of the reservoir 414 beingplaced in fluid communication with at least a portion of the applicationmechanism 418. In some implementations, the coupling feature 439 of thecartridge 413 includes a septum or other penetrable barrier and thecoupling feature 441 within the slot 437 of the housing includes a spikeor other element configured to penetrate the septum. In someimplementations, the housing may include a receptacle region sized andshaped to receive two or more cartridges.

FIG. 4F shows the distal tip of the coupling feature 441 extendingupward from within the receiver slot 437. The receiver slot 437 createsan inset surrounding the coupling feature 441 such that upon insertionand removal of the cartridge 413 solution from the reservoir 414 doesnot leak out of the slot 437. FIGS. 12H-12I illustrate an implementationof the device 400 in which the receiver slot 437 has an inset 493surrounding the coupling feature 441. The inset 493 is as deep as theportion of the coupling feature 441 available to penetrate couplingfeature 439 of the cartridge 413 is long. This prevents the couplingfeature 441 from extending into the slot 437 and eliminates thepossibility of solution leaking onto the outside surface of the housing412.

The slot 437 can also include one or more alignment features 450configured to engage with one or more corresponding surface features 451on the cartridge 413. Engagement between the alignment feature(s) 450and the surface feature(s) 451 provides a snap-in feel so the user isaware the cartridge 413 is properly in place within the slot 437. FIGS.6A-6B show an implementation of the cartridge 413 having a horizontalgroove 451 extending along a lower surface of the cartridge 413. FIG.12E and FIG. 12I illustrate another implementation of a cartridge 413having a pair of surface features 451 that are grooves extendingvertically along opposite sides of the cartridge 413. The grooves engagewith corresponding alignment features 450 within the slot 437 to aid insliding the cartridge in the correct orientation relative to the device400. The engagement between the alignment features 450 and the surfacefeatures 451 can vary. The cartridge 413 can be removed by pullingupward relative to the device 400 and snapped in by pushing downward onthe cartridge 413 relative to the device 400. The cartridge 413 caninclude additional surface features that aid a user's grip duringinsertion and removal of the cartridge 413. It should be appreciatedthat the cartridge 413 can engage with the housing 412 in various waysand is not limited to sliding. For example, the cartridge 413 can snaponto an exterior wall of the housing 412, can be threaded relative tothe housing 412, or can be dropped into a fully enclosed channel intothe interior 425 of the housing 412. Additionally, the cartridge 413need not be inserted from an upper surface 419 of the device and can beinserted from a side or elsewhere on the cartridge 413. The features ofthe cartridge 413 described herein can be incorporated with any of avariety of the devices 400 and should not be limited to any particulardevice 400 having any particular feature (i.e. contact or non-contactstyle applicator mechanism 418 of dispensing mechanism 430).

The application mechanism 418 of the device 400 can include a transferelement 427 and at least one applicator 429. The transfer element 427 isconfigured to transfer an amount of a liquid composition from thereservoir 414 to the applicator 429, which in turn is configured toapply the amount of the composition to the wipe W dispensed through thedispensing aperture 416 of the device 410. The transfer element 427 thusdrives the amount of composition in a direction towards the applicator429. The transfer element 427 can create a pressure differential betweenthe inside of the reservoir 414 where the composition is being storedand a region outside the reservoir 414. The pressure differential can becreated by the transfer element 427 due to creation of a positivepressure within the reservoir 414 pushing the amount of the compositiontowards the applicator 429. The pressure differential can be created bythe transfer element 427 due to creation of a negative pressure outsideof the reservoir 414 pulling the amount of composition towards theapplicator 429. In some implementations, the transfer element 427creates a positive pressure within the reservoir 414 by pressing on aregion of the reservoir 414 or the fluid inside the reservoir 414 andcausing displacement of the volume from the reservoir 414 through anoutlet. The transfer element 427 can shrink the chamber volume of thereservoir 414 forcing a volume of the composition from the reservoir414. The transfer element 427 can also expand a chamber volume outsidethe reservoir 414 causing a volume of the composition from the reservoir414 to flow towards the expanded chamber. The transfer element 427creates the pressure differential by a pumping action, either a manualpumping action or by an electric- or battery-powered motor to create thepumping action. In some implementations, a battery can be coupled to thereservoir 414 to drive the motor to create the pumping action. In thecase of a manually-created pumping action, the transfer element 427 caninclude a trigger, button, actuator, or other manual input or actuator431 that creates the pressure differential relative to the interior ofthe reservoir chamber 414 directly when pressed or squeezed or otherwisemanually actuated. In the case of an electrically-powered pumpingaction, the transfer element 427 can include a motor-powered mechanismto create the pressure differential relative to the interior of thereservoir chamber 414 upon actuation such as by a trigger, button,actuator, or other input that can be electrical or manual such asactuator 431. The transfer element 427 can also use gravity to transferan amount of the composition towards the applicator 429 and need notincorporate pumping action.

As mentioned above, the applicator 429 is configured to apply the amountof a liquid composition transferred by the transfer element 427 to thewipe W dispensed through the device 400. The configuration of the atleast one applicator 429 of the application mechanism 418 can vary. Insome implementations, the applicator 429 applies a composition to thewipe W by directly contacting the wipe W such as with one or morerollers, brushes, ball-bearing devices, or other contact elements knownin the art. FIGS. 4A-4K show implementations of devices incorporatingdirect contact style applicators. In other implementations, theapplicator 429 applies a composition to the wipe W without theapplicator 429 making direct contact with the wipe W, such as a sprayer,drip, atomizer, or other indirect application mechanism. FIGS. 11A-11Gshow implementations of devices incorporating non-contact styleapplicators. Each of the implementations will be described in moredetail below. As mentioned above, in certain implementations the devicemay include at least two reservoirs 414 or a single reservoir 414divided into at least two separate chambers which hold volumes ofdifferent compositions which may include, for example, two solutionswhich when applied to the wipe by actuation of the device form theindicator composition in situ on the wipe; or a indicator compositionand a disinfectant composition which are both applied simultaneously tothe wipe by actuation of the device. In accordance with theseimplementations, the applicator 429 may be configured to apply an amountof at least two different compositions to the wipe. For example, thedirect contact style applicator may be in the form of at least tworollers, brushes, ball-bearing devices, or other contact elements knownin the art, such that each contact element is adapted to deliver anamount of a different composition to the wipe. Preferably, theapplicator 429 is in the form of two rollers. Similarly, the non-contactstyle applicator may include at least two sprayers, drips, atomizers, orother indirect application mechanisms configured to apply an amount ofat least two different compositions to the wipe.

As will be described in more detail below, in some implementations, thedisclosure provides multi-component indicator compositions which providefor improved point of use disinfection by keeping separate until pointof use actuation of a device as described herein certain components thatwhen combined become unstable. For example, unstable components may bestored within separate compartments of the reservoir 414 of thecartridge 413 in their stable form and combined at the time of use toprovide higher potency without the drawbacks of instability.

The reservoir 414 can be divided into two, three, four, or moreseparated chambers within the cartridge 413. The number of chambers canvary and may depend upon the number of components and the need to keepcertain components physically separate from one another prior to use byapplication to a surface. It should be appreciated that the cartridge413 may have more reservoirs 414 than is used at any particular time.For example, a cartridge 413 may have four reservoirs 414, but onlythree reservoirs 414 are needed to formulate an appropriate disinfectingwipe.

In some implementations, the cartridge 413 can be a single chambercartridge containing a single liquid composition, such as a singlecomponent indicator composition or disinfectant composition as describedherein, or other composition as described above. Alternatively, thecartridge 413 can be divided into two or more chambers 414 containingtwo or more components of a multi-component liquid composition, such asa multi-component indicator composition as described herein. In someimplementations, the dispensing cartridge 413 can be divided into morethan two chambers 414, including three or more chambers 414, each of theplurality of chambers 414 containing a different component of amulti-component composition and separated from each other such that nopre-mixing of the separate components occurs.

In some implementations, each of the chambers can be associated with itsown nozzle for dispensing its contents. As such, the device 400 caninclude more than a single applicator 429 for each chamber. Adual-chambered reservoir 414 can have two applicators 429, atri-chambered reservoir 414 can have three applicators 429, and so on.Alternatively, a single applicator 429 can be configured to deliver thecontents of each of the chambers. For example, a single nozzle canarticulate relative to an outlet from each reservoir chamber 414. Thesingle nozzle can move to the outlet to dispense solution from the firstreservoir chamber 414 before moving to a second chamber outlet todispense solution from the second reservoir chamber 414, and so on. Theapplicator(s) 429 can dispense these solutions at appropriate volumesfor the end use. For example, a first applicator 429 can dispense afirst volume of fluid from the first reservoir chamber. A secondapplicator 429 can dispense a second volume of fluid from the secondreservoir chamber. The second volume of fluid can be the same ordifferent from the first volume of fluid. As described elsewhere herein,the first and second applicators 429 can be dedicated applicators fortheir particular reservoir chamber to avoid intermixing of solutions andinadvertent chemical reactions from occurring within the device 400. Asingle applicator 429 can be programmed to dispense the appropriatefluid volume from each reservoir chamber depending on its contents. Toprovide an example of the combinations of solutions and volumes, thefirst volume dispensed can be 1 mL of bleach and the second volumedispensed can be 9 mL water to create a 1:10 dilution for bleachdisinfection. It should be appreciated that any number of combinationsof solutions and volumes are considered herein and this is provided asan example.

In an implementation, each reservoir chamber incorporates a separate,dedicated applicator 429. Each applicator 429 can be programmed todispense to a particular region of a wipe rather than directly on top ofthe same part of the wipe. Thus, the applicators 429 can be arranged todispense in parallel, in series, or in combinations of both. In animplementation, the applicator 429 is a sprayer having a nozzle asdescribed elsewhere herein. The applicator 429 can include a pluralityof nozzles arranged to dispense according to a particular pattern. Theplurality of nozzles can be arranged in pairs, 3 to a row, 4 to a row, 4to a column, a grid of 2×2 nozzles, 3×2 nozzles, etc. The plurality ofnozzles can be arranged according to a shape such as a rectangle,diamond, pentagon, hexagon, heptagon, octagon, circle, etc. Anydesirable nozzle configuration may be designed and used to dispense thesolutions from the chambers.

Additionally, the plurality of nozzles can be configured to dispensetheir respective solutions at different times. A first nozzle candispense from a first chamber for a first time (e.g. 0.5 seconds) and asecond nozzle can dispense from a second chamber for a second time,where the times are the same or different. The nozzles can be configuredto dispense simultaneously or in series. For example, the first nozzlemay dispense for a first period of time after which a second nozzle isactivated to dispense for a pre-determined time. Each nozzle can beconfigured to dispense at different times and for different lengths oftime. For example, a first nozzle can dispense a solution for 1 second,pause for a pre-determined time, and then may dispense for 1, 2, 3, ormore additional seconds.

The plurality of nozzles can be configured to spray their respectivesolution in a spray, fine mist, thick stream, or otherwise. Theconfiguration of application provided by the plurality of nozzles can bedue to orifice size, flow rate, pressure, and/or orifice shape. Itshould be appreciated that the various configurations of dispensingfluid can be due to the programming of the computing system 495 and canbe optimized, customized, or otherwise adjusted based on the desiredresult.

In still further implementations, the device 400 can incorporate amixing chamber such that the solutions from different chambers can bemixed together prior to be dispensed. The mixing chamber can be near anarea where the solutions from the chambers can combine. In someimplementations, the mixing chamber can be positioned within a region ofthe cartridge 413. The mixing chamber can include a mixing mechanismsuch as a stir bar or other movable component to ensure the solutionscombined within the mixing chamber are more homogenously dispensed. Insome implementations, the nozzle can communicate with the mixing chamberto dispense the mixed solutions. In some implementations, the mixingchamber can be positioned within the device 400 such that a wipe can bepulled through the mixing chamber to be soaked with the mixed solutionrather than sprayed or pumped out of the mixing chamber onto the wipe.

Again with respect to FIGS. 4E-4F, the reservoir 414 of the cartridge413 can be pre-filled prior to use with a single or multi-componentliquid composition, such as an indicator composition and/or adisinfectant composition as described herein, or other composition asdescribed above. The cartridge 413 can be a single-use disposableelement or can be refilled upon emptying. The cartridge 413 can befilled in various ways such as a septum or other feature configured tobe penetrated or opened for filling. For example, the cartridge 413 canbe filled through the septum of the coupling feature 439. The volume ofthe reservoir 414 contained within the cartridge 413 can vary, butgenerally, the volume is sufficient to accommodate the number of wipes Aprovided by a single canister C. The cartridge 413 can include a fillline or other metering system 411 (see FIG. 11B) visible from anexterior of the device 400 so a user can easily ascertain the remainingvolume of the composition in the reservoir 414 of the cartridge 413. Insome implementations, the side wall 421 of the housing 412 can have acut-out 448 or other feature that reveals an outer wall of the cartridge414 through the cut-out 448 from outside the housing 412 when thecartridge 413 is positioned within the slot 437. The cartridge 413 caninclude a lip 443 near the top that facilitates pulling the cartridge413 out of the slot 437. The shape of the cartridge 413 can vary, butgenerally the cartridge 413 is shaped to conform to the overall shape ofthe housing 412 when engaged with the slot 437. The cartridge 413 caninclude mechanical interlocking features such that the device 400 canonly be used with a specific cartridge 413 keyed to connect with thedevice 400. The cartridge 413 can include a data element 424 or anencoder strip such as a bar code, QR code, RFID chip, or other featurethat allows the cartridge 413 to be scanned and read by a reader device.The reader device can be a separate device or a part of the device 400.The element 424 can also for a user to assess information about thecartridge 413 as will be described in more detail below.

The cartridge 413 can also include more than a single reservoir 414. Forexample, the cartridge 413 can include multiple reservoir chamberswithin a single cartridge 413. The different reservoir chambers can beformed by one or more septa or inner walls extending within the interiorof the cartridge 413 separating the interior into individual reservoirchambers configured to contain the different components of amulti-component indicator composition, a single component indicatorcomposition, and/or a disinfectant composition and one or more optionaladditives, such as a surfactant. The different compositions, and/orcomponents and/or additives can then be dispensed simultaneously fromtheir respective chambers.

The reservoir 414 and the application mechanism 418 are arranged to workin concert to apply an amount of a liquid composition, such as thedisinfectant composition and/or indicator composition described herein,or other composition as described above, which is stored within thereservoir 414 to a wipe W as it is dispensed from its canister C throughthe dispensing aperture 416 of the device 400. As with respect to otherimplementations described herein, the wipe W can be dispensed from thedevice 400 manually such as by a user pulling the wipe W through thedispensing aperture 416 in the top surface 419. The wipe W may also bedispensed through the device 400 by an automatic feed system thatincludes a powered motor. The application mechanism 418 of the device400 can include a transfer element 427 and at least one applicator 429.The transfer element 427 is configured to transfer an amount of a liquidcomposition, such as the disinfectant composition and/or indicatorcomposition described herein, or other composition as described above,from the reservoir 414 to the applicator 429, which in turn isconfigured to apply an amount of the composition to the wipe W dispensedthrough the dispensing aperture 416 of the device 400. The transferelement 427 drives the amount of composition in a direction towards theapplicator 429. The transfer element 427 can create a pressuredifferential between the inside of the reservoir 414 where thecomposition is stored and a region outside the reservoir 414. Thepressure differential can be created by the transfer element 427 due tocreation of a positive pressure within the reservoir 414 pushing theamount of composition towards the applicator 429. The pressuredifferential can be created by the transfer element 427 due to creationof a negative pressure outside of the reservoir 414 pulling the amountof composition towards the applicator 429. The transfer element 427 cancreate the pressure differential by a pumping action, either a manualpumping action or by an electric- or battery-powered motor to create thepumping action. In some implementations, a battery can be coupled to thecartridge 413 and/or the reservoir 414 contained in the cartridge 413 todrive a motor to create the pumping action. In the case of amanually-created pumping action, the transfer element 427 can include atrigger, button, actuator, or other manual input 431 that creates thepressure differential relative to the interior of the reservoir chamber414 directly when pressed, squeezed, or otherwise manually actuated. Insome implementations, the transfer element 427 can include a pumpingelement 463 that is electrically-powered by a motor to create thepressure differential relative to the interior of the reservoir chamber414 upon actuation of a trigger, button, or other input, which will bedescribed in more detail below.

The actuators described herein for dispensing the liquid composition canbe a dispense button that is easy to actuate and well within view of auser. The button can have a particular distinguishing color, such asblue where the remainder of the device is primarily another color. Itshould be appreciated that the inputs for dispensing the liquidcomposition can be a mechanical button or actuator that causes movementof another component of the device. The actuator may also be anelectrical input that causes dispensing by communicating a signal to acontroller as will be described elsewhere herein. Reference to anactuator or an input is not intended to be limiting and may be usedinterchangeably.

The actuator 431 can cause the transfer element 427 and the applicators429 to engage such that a liquid composition, such as the disinfectantcomposition and/or indicator composition described herein, or othercomposition as described above, can be applied to the wipe W beingdispensed through the device 400. The configuration of the at least oneapplicator 429 of the application mechanism 418 can vary. The applicator429 can apply the liquid composition to the wipe W by directlycontacting the wipe W. In this implementation, the applicator 429 can beone or more rollers, brushes, ball-bearings, or other direct contactelement known in the art. The one or more applicators 429 can alsoinclude a sprayer, or other non-contact configuration, which will alsobe described in more detail below. The transfer element 427 andapplicators 429 work in concert with one another and with the reservoir414 to control flow of the composition from the reservoir 414 to thewipe W.

As mentioned above, the slot 437 within which the cartridge 413 isreceived by the housing 412 can include a coupling feature 441configured to penetrate a lower end region of the cartridge 413. As bestshown in FIGS. 7A-7C, the coupling feature 441 can be a pneumatic tap455 having an end configured to penetrate the coupling feature 439 ofthe cartridge 413. The tap 455 can include at least one opening 457 intoa lumen 459 extending through the tap 455 such that when the tap 455inserts through the septum of the coupling feature 439 on the cartridge413, the interior of the reservoir 414 is put into fluid communicationwith the lumen 459 of the tap 455 through the at least one opening 457.The lumen 459 of the tap 455 is configured to be in fluid communicationwith a conduit 461 leading to the applicator 429. A pumping element 463(which can be part of the transfer element 427) can be activated to urgethe liquid composition from the reservoir 414 towards the applicator 429through the conduit 461, for example due to creation of a pressuredifferential relative to the reservoir 414. The pumping element can urgefluid from the reservoir 414 by positive and/or negative pressure.

The tap 455 can also include a vent 456 or other feature to allowequilibration of pressure within the reservoir 414 upon displacement offluid by the pumping element 463 (see FIGS. 7A-7C). A vent 491 canadditionally be positioned within a region of the cartridge 413 (seeFIGS. 12A-12E). The vent 491 can incorporate a one-way valve that allowsequalization of pressure on either side of the valve. In someimplementations, the valve is a duckbill valve configured to break openupon generation of a certain threshold amount of negative pressurewithin the reservoir 414 placing the interior of the reservoir 414 influid communication with the atmosphere. The vent 491 prevents thecreation of a vacuum within the reservoir 414.

The configuration of the pumping element 463 can vary. The pumpingelement 463 can be a positive displacement, reciprocating, rotary,piston, diaphragm, peristaltic, dynamic, centrifugal, hydraulic,valved-gravity feed, or other pump type. In some implementations, thepumping element is a peristaltic pump. The peristaltic pump can providea quieter and more durable operation that is resistant to clogging anddrips. The pumping element 463 can urge fluid from the reservoir 414 bypositive or negative pressure. The pumping element 463 can incorporate adosed valve that allows for gravity feed of the liquid compositiontowards the applicator 429. FIGS. 8A and 8B illustrate oneimplementation of a pumping element 463 that can cause fluiddisplacement from the reservoir 414 towards the applicator 429.

In some implementations, the pumping element 463 can include a diaphragm465, an internal chamber 466, an inlet conduit 464 leading toward theinternal chamber 466, and an outlet conduit 467 leading from theinternal chamber 466. The pumping element 463 can include a one-wayvalve 462 a upstream from the internal chamber 466 within the inletconduit 464 as well as a one-way valve 462 b downstream from theinternal chamber 466 within the outlet conduit 467 (see FIG. 9 ). Theone-way valves 462 a, 462 b can ensure unidirectional fluid flow fromthe reservoir 414 towards the applicator 429. The configuration of thevalves 462 a, 462 b can vary. In some implementations, the valves 462 a,462 b are check valves. The cartridge 413 can be coupled to the device400 such that the lumen 459 of the tap 455 is placed into fluidcommunication with the interior of the reservoir 414 via opening 457. Asthe diaphragm 465 of the pumping element 463 is displaced inward, apressure differential is created that draws fluid from the reservoir 414into lumen 459 via the opening 457. The fluid is directed past one-wayvalve 462 a into the inlet conduit 464 leading to the internal chamber466 of the pumping element 463. Fluid is ejected from the internalchamber 466 through outlet conduit 467 past one-way valve 462 b towardconduit 461 leading to the one or more applicators 429. The applicator429 can include at least one outlet 468 through which the amount of theliquid composition displaced from the reservoir 414 is released.

In other implementations, the pumping element 463 can include a manualspray mechanism that pumps the liquid composition from the reservoir 414towards the applicator 429 by user depression of the actuator 431, suchas like a manual spray bottle mechanism (see FIG. 12E). For example, auser pushing on the actuator 431, such as a lever or other manualmechanism, can trigger the sprayer applicator 429 mechanically thatpumps/sprays the indicator solution from the reservoir 414 onto the wipeW. Additional pushes of the actuator 431 result in additional amounts ofthe liquid composition being transferred and applied as it is pulled outfrom the upper surface 419 or side surface 421.

The one or more applicators 429 of the device 400 can allow forone-sided or two-sided application of the liquid composition to the wipeW. In some implementations, the device 400 can include a pair ofapplicators 429 (see FIG. 10 ). The pair of applicators 429 allows fortwo-sided application of the composition to the wipe W. Each applicator429 can include a roller 475 near an upper end and a hinge element 480at a lower end. The hinge element 480 allows the applicator 429 to bemoved as will be described in more detail below. In someimplementations, the hinge element 480 can be shoulder bolts and includea pair of knuckles configured to receive a pin. The roller 475 cansurround an inner shaft 476 through which the conduit 467 extendsleading to the one or more outlets 468 formed in a wall of the innershaft 476. As the liquid composition is directed through the conduit 467and out the outlets 468, the material of the roller 475 is saturatedwith the liquid composition. The material of the roller 475 can vary.Generally, the material has wicking and transfer properties and isrelatively durable. The material can be relatively durable even inoxidizing or reducing environments such as in the presence of bleach.The material can have a relative high coefficient of friction with thewipe W. The material of the roller 475 can include foam rubber, knit,sponge formed of one or more of melamine-, polyester-, polyurethane-,polyimide-, polyethylene-, vinyl-, and polyolefin-based materials. Thematerial of the roller 475 can include Essentra PT X-6981C, EssentraCloth, CAPUCELL, and Magic Sponge. The material of the roller 475 caninclude ethylene propylene diene monomer (EPDM) foam rubber as well asvarious other foams such as polyimide foam, polyethelene foam, vinylfoam, Viton foam, silicone foam, ionomer foam, natural gum foam, ECHfoam, and neoprene. The material of the roller 475 can include cellulosesponge and polyester wrapped fibers. The material of the roller 475 caninclude a coating to improve its transfer and wicking properties such asa hydrophilic coating. In some implementations, the material of theroller 475 is EPDM with a hydrophilic coating. In some implementations,the roller 475 can be a two-part roller in which an inner core of highlyabsorbent material, such as foam, is wrapped with a thin cloth-likematerial that can transfer fluid well while being very durable and havea coefficient of friction that is higher than a coefficient of frictionof the wipe W.

As described above, actuating an input of the device 400 cansimultaneously activate or move the applicators 429 and activate thetransfer element 427 to pump fluid toward the applicators 429. Themechanism by which the actuator 431 engages the transfer element 427 andapplicators 429 can vary. In some implementations and as shown in FIGS.4I-4K, the actuator 431 can be mechanical and have an outer portion 470that extends outside the interior 425 of the housing 412, such asthrough the upper surface 419 of the housing 412, and an inner portion472 that resides within the interior 425 of the housing 412. Theactuator 431 can be biased in an upward position. The actuator 431returns to its initial upward position after being depressed by a userto a downward position and released. The inner portion 472 of theactuator 431 can lie adjacent to a slider 474 that engages both theapplicators 429 and the pumping element 463. The actuator 431 is urgedagainst an upper surface of the slider 474 or otherwise moves the slider474 when it is depressed by a user. The slider 474 can be coupled to theapplicator 429 so that the actuator 431, the slider 474, and theapplicator 429 move in concert with one another. The slider 474 alsoactivates the pumping element 463 as it is moved. This arrangement movesthe rollers 475 together and pumps fluid towards the applicator 429 witha single depression of the actuator 431. It should be appreciated thatthe activation of the applicators 429 and/or transfer element 427 neednot be mechanical and can incorporate electrical circuitry to activatethe various components of the device 400, as described in more detailbelow.

In some implementations, the slider 474 has a pin 473 configured toinsert through and slide within an elongate slot 477 of the applicator429 (see FIGS. 4I-4K). As mentioned above, each applicator 429 caninclude a roller 475 at an upper end and a lower end movably coupled tothe plate 436 by a hinge element 480. The pair of applicators 429 can becoupled to the plate 436 on opposite sides of the internal opening 415through which a wipe W can extend into the interior 425 of the housing412. The applicators 429 are movably coupled to the plate 436 via theirhinge element 480. The rollers 475 can be moved in a rocking motiontoward and away from each other depending on whether the actuator 431 isdepressed. The actuator 431 and the applicators 429 are biased into afirst position where the actuator 431 is urged upward and the rollers475 are angled outward and separated a distance away from one another.Upon depressing the actuator 431, the inner portion 472 of the actuator431 is urged downwards against the slider 474, which in turn moves itdownwards. The pin 473 slides within the slot 477 of the applicator 429as the slider 474 is urged downwards. This causes the applicators 429 torock from the first position in which the rollers 475 are angled outwardaway from one another to a second position in which the rollers 475 rocktowards one another above the opening 415. As described above, the wipeW extends from its canister C through the opening 415 into the interior425 of the device 400. The rollers 475 rocked into the second positionthereby contact the wipe W therebetween in order to transfer or imbuethe liquid composition onto the wipe W as the wipe W is advanced pastthe rollers 475. The actuator 431 is depressed as the wipe W is advancedthrough the interior 425 and out the dispensing aperture 416. A singlewipe W can be advanced or multiple wipes A can be advanced with a singleactuation of actuator 431. As mentioned elsewhere herein, the wipe W canbe advanced manually such as by pulling action or can be advanced by apower feed system, which will be described elsewhere herein. In additionto causing the rollers 475 to rock towards one another, the movement ofthe actuator 431 and thus, the slider 474 can activate the pumpingaction of the transfer element 427 to saturate the rollers 475 with theliquid composition stored within the reservoir 414. As mentioned above,the transfer element 427 can include a pumping element 463. In someimplementations, the pumping element 463 is a diaphragm pump positionedunderneath the slider 474. As the slider 474 is moved downwards andurges the rollers 475 towards one another, the underside of the slider474 is simultaneously urged against a diaphragm 465 (or otherwiseactivate the pumping element 463 if another type of pumping element463). This generates a pressure differential causing fluid to bedisplaced from the reservoir 414 into the conduit 461 towards therollers 475 of the applicators 429, which are being rocked towards oneanother to grab the wipe W therebetween.

As mentioned above, hinging at least a portion of the device 400 into anopened position may be helpful when a user needs to assist with primingthe first wipe W into the device 400. For example, the lead wipe W inthe canister C may be primed or engaged with the device 400 by unlockingthe release button 445 to expose at least a region of the interior 425.Upon unlocking the release button 445, the upper portion 417 of thehousing 412 can be opened by rotating it around the hinge element 435exposing the opening 415 in the plate 436. The lead wipe W of theinterconnected sheets in the canister C can be pulled through theopening 415 into the interior 425 of the housing 412. The lead wipe W isthen threaded through the interior 425 such that the wipe W is broughtinto proximity with the applicator 429 of the application mechanism 418(e.g. rollers or sprayer in the case of non-contact applicator).Threading the lead wipe W through the opening 415 can help to limit theangle at which the wipe W is positioned between the applicators 429,such as the rollers 475 of the applicators 429. The lead wipe W can bethread up between the pair of applicators 429 without coming into directcontact with the rollers 475. The leading edge of the lead wipe W isinserted then through the dispensing aperture 416. The locking element490 can help thread the first or lead wipe W into the cap 485. After thelead wipe W is primed, the locking element 490 need not be used againuntil all the wipes W in the canister C are depleted and a new lead wipeW is to be primed. In other implementations, the lead wipe W can bethreaded through the plurality of guide rollers 538 so that the wipe Wis brought into proximity with the applicator 429 of the applicationmechanism 418 by threading the wipe W through the plurality of guiderollers 438 so that the wipe W lies horizontally underneath the flowdiverter 469 such that the diverter directs the solution onto the wipe W(see FIG. 11D). The leading edge of the lead wipe W is inserted thenthrough the dispensing aperture 416.

As mentioned above, the devices described herein can include applicatorsconfigured to apply the amount of the liquid composition transferred bythe transfer element to the wipe dispensed through the device. Theconfiguration of the applicators can vary depending on whether theapplicator contacts the wipe directly or avoids coming into contact withthe wipe. Described above are applicators that apply a liquidcomposition to the wipe by directly contacting the wipe such as with aroller, brush, ball-bearing, or other direct contact device. In aninterrelated implementation, the applicator can apply a liquidcomposition to the wipe without the applicator making direct contactwith the wipe, such as with a sprayer head as will be described in moredetail below. It should be appreciated that features described above inthe context of the contact applicator devices can also be incorporated,where appropriate, with the non-contact applicator devices.

FIGS. 11A-11G illustrate an interrelated implementation of a devicehaving a non-contact applicator or an applicator configured to apply theamount of a liquid composition to the wipe without directly contactingthe wipe. As with other implementations described herein, the device 400can include a housing 412 having a dispensing aperture 416 and anapplication mechanism 418.

In the implementation shown in FIGS. 11A-11G the dispensing aperture 416is shown in a side surface 421 of the housing 412. A lower end region423 of the housing 412 can define an internal aperture or opening 415.When the housing 412 is coupled to a region of a canister C of wipes W,the wipe W stored within the interior of the canister C can be drawninto the interior 425 of the housing 415 through the opening 415. Thewipe W can be fed through the interior 425 towards the dispensingaperture 416 in the housing 412.

The device 400 can include a dispensing mechanism 430 that is anautomatic dispensing mechanism or manual. The dispensing aperture 416for the automatic dispensing mechanism 430 can be a generallyrectangular-shaped dispensing aperture 416 whereas the manuallydispensed configuration may incorporate a zig-zag shaped dispensingaperture 416 although it should be appreciated that other shapes can beused. The dispensing aperture 416 can include a cover 494 positionedover the dispensing aperture 416 to avoid inadvertent drying out of thewipes W in their canister C and within the device 400 (see FIG. 11E).The cover 494 can be hinged such that the cover 494 can be manually ormechanically opened.

The cover 494 can include a spring-loaded hinge that opens when anactuator is pushed. The actuator 431 can simultaneously release thecover 494, activate the transfer element 427 to pump a liquidcomposition towards the applicator 429, and activate the applicator 429to apply the transferred a liquid composition to the wipe A. Theactuator 431 can also simultaneously activate any gripper, pincherelements 432 so that the saturated wipe W is released and ready for use.The cover 494 can also automatically close (and the gripperautomatically released) when the actuator 431 is released to prevent thewipes W within the canister C from drying out. Consolidating theactivation of the various mechanisms into a single actuation simplifiesuse of the device 400 such that it can be used with a single hand. Itshould be appreciated, however, that the various components can alsoinclude their own actuator and/or be configured for manual use.

The one or more applicators 429 of the device 400 can allow forone-sided or two-sided application of the liquid composition to the wipeW. The applicator 429 can include a conduit 461 having at least oneoutlet 468 through which the amount of the liquid composition displacedfrom the reservoir 414 is released through the applicator 429. Theapplicator 429 can include any of a variety of sprayers, including theliquid sprayers described in U.S. Pat. No. 8,602,386, WO 2006/101730,and WO 2009/085175, which are each incorporated by reference herein.

The applicator 429 can be arranged relative to the dispensing aperture416 such that spray from the outlet 468 can be directed toward the wipebeing dispensed through the dispensing aperture 416. In someimplementations, the applicator 429 includes a spray diverter 469positioned across from the outlet 468. The spray diverter 469 caninclude a surface shaped to re-direct the sprayed composition exitingfrom the outlet 468 onto a surface of a wipe W being dispensed or fedthrough the dispensing aperture 416. In some implementations, the spraydiverter 469 is arranged above the wipe W such that the spray diverter469 re-directs the sprayed liquid composition downward onto an uppersurface of the wipe W. The surface of the spray diverter can re-directthe sprayed liquid composition directly onto the wipe W or at an anglesuch as by incorporating a spray diverter 469. The spray diverter 469can allow for an even distribution of the liquid composition onto thewipe W. The spray diverter 469 can re-direct the sprayed compositionalong any number of angles such that it drips down onto the wipe W. Insome implementations, the angle of re-direction is between 45 degreesand 90 degrees relative to an axis of the spray discharge from theoutlet 468. In other implementations, the angle of re-direction is lessthan 45 degrees relative to an axis of the spray discharge or greaterthan 90 degrees relative to an axis of the spray discharge from theoutlet 468. The spray diverter 469 can have a curved surface configuredto receive a liquid composition from the outlet 468 against an upperregion of the curved surface such that the liquid composition drips downor waterfalls along the curved surface onto the wipe W to achieve a moreeven distribution than could potentially be achieved by sprayingdirectly onto wipe W. In other embodiments, outlet 468 can be coupledwith a diffuser to achieve a more even distribution with or withoutspray diverter 468. The upper surface of the wipe W and the applicator429 can be positioned generally parallel to each other and horizontalrelative to the plate 436 of the device 400. An overflow container 458can be positioned below the wipe W and sized to collect excess liquidcomposition that is not imbued into the wipe W.

As mentioned above, the device 400 can have a dispensing mechanism 430that is configured for a user to manually pull the wipe through thedispensing aperture 416 and/or a dispensing mechanism 430 that includesan automatic feed system having a powered drive motor 434 and aplurality of gear rollers 438. The gear rollers 438 are configured tocapture and direct the wipe W through the interior 425 of the device 400towards the dispensing aperture 416. As shown in FIG. 11D, the wipe Wcan extend from its canister C through the opening 415 into the interior425 of the device 400. At least a first gear roller 438 of the automaticdispensing mechanism 430 can contact the wipe W and direct it toward oneor more additional gear rollers 438 towards the dispensing aperture 415.

The gear roller 438 can have teeth or grooves 420 for providing frictionto engage with the gear driven by the motor as well as with other gearrollers 438 involved in feeding the wipe W out of the device 400. Forexample, FIG. 12G shows an implementation of the device 400 including amotor 434 having a gear that drives a gear roller 438. The gear roller438 can include grooves 420. The grooves 420 provide friction with theother rollers 438 that work in coordination to dispense out the wipe W.One or more of the rollers 438 can be spring-loaded to help roll thewipes out and apply some pressure to keep the wipes stabilized as theydispense.

Device 400 can removably attach to adapter 700 to removably ordetachably couple device 400 to a range of sizes of canister C of wipesW. The top of adapter 700 features an adapter lip 701 (FIG. 13A) wheredevice 400 removably attaches. The bottom of adapter 700 (FIG. 13B)features an adapter lip 702 where canister C removably attaches. Adapter700 contains an aperture 703 (FIG. 13C) through which wipes W go throughto communicate with device 400.

The upper lip 701 of the adapter 700 is sized and shaped to interfacewith a lower end region of the device 400 housing such that the adapter700 and the device 400 can be reversibly coupled together. For example,the inner diameter of the upper lip 701 can be sized and shaped toencircle the lower end region of the device housing. Alternatively, theouter diameter of the upper lip 701 can be sized and shaped to bereceived within an interior of the lower end region of the devicehousing. In some implementations, one or more connecting features on thelower end region of the housing of the device 400 can removably attachto the upper lip 701 of the adapter 700. Similarly, the lower lip 702 ofthe adapter 700 is sized and shaped to interface with an upper endregion of the canister such that the adapter 700 and the canister can bereversibly coupled together. For example, the inner diameter of thelower lip 702 can be sized and shaped to encircle the upper end regionof the canister. Alternatively, the outer diameter of the lower lip 702can be sized and shaped to be received within an interior of the upperend region of the canister. In some implementations, one or moreconnecting features on the upper end region of the canister canremovably attach to the lower lip 702 of the adapter 700. The upper lip701 of the adapter 700 can have a first dimension and the lower lip 702of the adapter 700 can have a second, larger dimension such that theadapter 700 can be used to connect the device 400 with larger sizedcanisters. The device 400 can include one or more connecting features onthe lower end region of the housing that are configured to removablycouple the device to the adapter 700. The adapter 700 can include one ormore sensors 705 (see FIGS. 14A-14D) configured to interface with thedevice 400 and/or the canister and will be described in more detailbelow.

Regardless whether the wipe W is advanced using a manual dispensingmechanism 430 or an automatic or powered dispensing mechanism 430, thedevice 400 can include one or more grippers 432. The gripper 432 allowsfor a user to more easily tear the wipe W after dispensing. The gripper432 can be formed of a gripper lift arm 460 and a gripper blade 471. Thegripper lift arm 460 can be spring-loaded and actuated by the actuator431. Depressing the actuator 431 can release the gripper lift arm 460from engagement with the wipe W releasing it from being trapped betweenthe gripper lift arm 460 and the gripper blade 471. The gripper blade471 can hold the wipe W once a spray cycle is complete therebypreventing a user from inadvertently pulling multiple wipes A throughthe dispensing aperture 416.

The actuator 431 can simultaneously activate the application mechanism418, the dispensing mechanism 430, and the gripper 432. The user upondepressing the actuator 431 can advance (e.g. manually pulling or bypowered gear rollers 438) the wipe W out the dispensing aperture 416 asa liquid composition is sprayed onto the wipe W. Upon releasing theactuator 431, the gripper lift arm 460 of the gripper 432 is released toreturn to its starting position engaged with the wipe W allow for easytearing off of the wipe W from the remainder of the sheets.

The actuator 431 can activate the application mechanism 418, includingthe transfer element 427 to pump fluid toward the applicators 429, andsimultaneously activate the dispensing mechanism 430 (if applicable).The mechanism by which the actuator 431 activates the applicationmechanism 418 and the dispensing mechanism 430 can vary. The sprayingrate of the applicators 429 can be linked to the feed rate of thedispensing mechanism 430 such that the device 400 provides consistentspray volumes to the wipe W. The transfer element 427 can also includeone or more valves, such as a piston pump with check valves that allowfor consistent spray volumes. Thus, the device 400 can be abattery-powered motorized sprayer that allows for control of the amountof a liquid composition applied to each wipe W being dispensed, whichwill be discussed in more detail below. Depressing the actuator 431activates the applicators 429 of the application mechanism 429 and alsothe transfer element 427 such that the spraying of a liquid compositionis initiated. Depressing the actuator 431 also releases the gripper 432.This allows the wipes W to be pulled (or advanced automatically by motor434) horizontally through the dispensing aperture 416 to get coated in aliquid composition. When the actuator 431 is released, the gripper liftarm 460 is allowed to travel down towards the wipe W to clamp the wipe Wagainst the gripper blade 471 such that the lead wipe W extending beyondthe dispensing aperture 416 can be torn off or released entirely. Thus,the device 400 can be fully automated with a push of a button andwithout any manual pulling of the wipe. Activation of the device 400also need not include mechanical actuation and can incorporateelectrical circuitry to activate any of the various components of thedevice 400. The input need not be a mechanical actuator or button thatis physically depressed by a user. For example, the input (as well asany of the actuators described herein) can be a motion sensor such thatupon waving of a hand over the sensor the input is electronicallyactuated in a “touchless” manner.

The device 400 can additionally incorporate one or more locks orswitches to prevent inadvertent dispensing and/or application. Forexample, the system can incorporate an actuation lock to preventoversaturation of the applicator 429 and/or the wipe W due to excessivepumping when a wipe W is not removed from the device 400. In anotherexample, cover 494 is attached to a limit switch that can detect thepresence of wipe W and prevent dispensing and/or running of motor 434 ifno wipe W is detected.

Electronics and Data Tracking

FIG. 1B is a block diagram showing an implementation of a deviceincluding a computing system 495. The computing system 495 can beconfigured to power, sense, monitor, and/or control one or morefunctions of the device 400. FIG. 1B shows the application mechanism 418of the device 400 can include the transfer element 427, such as aperistaltic pump, and at least one applicator 429, such as a sprayer.

As described in more detail above, the application mechanism 418 of thedevice 400 can incorporate a powered motor, such as a battery-poweredmotor sprayer system. The motor for such an application mechanism 418can be under the control of the computing system 495. The dispensingmechanism 430 of the device 400 can include an automatic feed systemincluding a powered drive motor 434 and a plurality of gear rollers 438configured to drive the wipes upon actuation of an input. The motor 434can drive (directly or via one or more gears) the gear roller 438configured to capture and direct the wipe W towards the dispensingaperture 416. The dispensing mechanism 430 can additionally include thegripper 432 that allows for a user to more easily tear the wipe W afterdispensing and the cover 494 configured to close the dispensing aperture416. The drive motor 434 for the dispensing mechanism as well as thegripper 432 can be under the control of the computing system 495. Itshould be appreciated that the one or more grippers 432 can beincorporated regardless whether the dispensing mechanism 430 is a manualmechanism as described elsewhere herein or a powered dispensingmechanism. Actuation of the input can simultaneously activate theapplication mechanism 418, the dispensing mechanism 430, including thegripper 432. Each of the application mechanism 418 and the dispensingmechanism 430 can be in communication with and under the control of thecomputing system 495. The computing system 495 in the device 400 allowsfor the device 400 to connect and exchange data thereby allowing thedevice 400 to more directly integrate with the environment within whichit will be used. The computing system 495 allows for remote monitoringand control of the various functions of the device 400 therebyincreasing its usefulness beyond merely applying a solution to a wipe atthe indicator.

It should be appreciated that the computing system 495 can beincorporated within any of the various devices described hereinregardless the method of application (i.e. contact or non-contact).Thus, any of the device embodiments described herein can incorporate oneor more functions of the computing system 495, which will be describedin more detail below. Certain features that are described in thisspecification in the context of separate embodiments and implementationscan also be implemented in combination in a single embodiment.Conversely, various features that are described in the context of asingle embodiment can also be implemented in multiple embodimentsseparately or in any suitable sub-combination. Moreover, althoughfeatures may be described as acting in certain combinations and eveninitially claimed as such, one or more features from a claimedcombination can in some cases be excised from the combination, and theclaimed combination may be directed to a sub-combination or a variationof a sub-combination.

Again with respect to FIG. 1B, the computing system 495 of the device400 can include a user interface 505, a processor 510, a communicationport 515, one or more sensors 520, a power source 525, and a memory 530.

The processor 510 is capable of processing instructions for executionwithin the computing system 495. Such executed instructions canimplement one or more of the methods described herein. The processor 510can process instructions stored in the memory 530 as is known in theart.

The memory 530 is a computer readable medium such as volatile ornon-volatile that stores information within the computing system 495.The memory 530 can be any type of memory capable of storing data andcommunicating that data to one or more other components of the device,such as the processor. The memory 530 may be one or more of a Flashmemory, SRAM, ROM, DRAM, RAM, EPROM, dynamic storage, and the like. Thememory 530 can receive and store data acquired during use of the device400, such as from the one or more sensors 520, the user input 505, andother information related to dispensing the wipes and applying asolution to the wipes. The memory 530 can store user information,history of use, and various other data as will be discussed in greaterdetail below.

One or more aspects or features of the subject matter described hereinmay be realized in digital electronic circuitry, integrated circuitry,specially designed ASICs (application specific integrated circuits),field programmable gate arrays (FPGAs) computer hardware, firmware,software, and/or combinations thereof. These various implementations mayinclude implementation in one or more computer programs that areexecutable and/or interpretable on a programmable system including atleast one programmable processor, which may be special or generalpurpose, coupled to receive signals, data and instructions from, and totransmit signals, data and instructions to, a storage system, at leastone input device, and at least one output device. The programmablesystem or computing system may include clients and servers. A client andserver are generally remote from each other and typically interactthrough a communication network. The relationship of client and serverarises by virtue of computer programs running on the respectivecomputers and having a client-server relationship to each other.

These computer programs (also known as programs, software, softwareapplications or code) include machine instructions for a programmableprocessor, and may be implemented in a high-level procedural and/orobject-oriented programming language, and/or in assembly/machinelanguage. As used herein, the term “machine-readable medium” refers toany computer program product, apparatus and/or device (e.g., magneticdiscs, optical disks, memory, Programmable Logic Devices (PLDs)) used toprovide machine instructions and/or data to a programmable processor,including a machine-readable medium that receives machine instructionsas a machine-readable signal. The term “machine-readable signal” refersto any signal used to provide machine instructions and/or data to aprogrammable processor.

To provide for interaction with a user, one or more aspects or featuresof the subject matter described herein can be implemented via the userinterface 505. The user interface 505 is configured to receive one ormore inputs from a user and to provide one or more outputs to the user.The input from the user can be received in any of form includingacoustic, speech, motion, or tactile input. The inputs can varyincluding pushbuttons, keypads, actuators, touchscreens, or other inputsas described elsewhere herein. The actuator 431, described in moredetail above, is an example of an input that is part of the userinterface 505. The inputs of the user interface 505 can be a mechanicalactuator or an electric element. In some implementations, the userinterface 505 can include a motion or optical sensor as described aboveto allow for touch-free dispensing of a wipe. The motion or opticalsensor can be triggered after reaching a minimum threshold. For example,the device can be programmed to require at least 2 seconds of continuousmotion detected by the sensor in order to dispense, thereby preventingaccidental dispensing. The touch-free dispensing can be controlled suchthat a length of wipe extended is suitable for the type of wipe withinthe canister C and automatically dispenses out the appropriate length.For example, a light sensor can track perforations between individualwipes and automatically dispense to the location of the perforations.

In other implementations, the user interface 505 can include amicrophone capable of receiving auditory inputs from a user. The devicesdescribed herein are configured to provide feedback to the user. Thefeedback can be any form of sensory feedback, such as for example visualfeedback, auditory feedback, or tactile feedback. The feedback providedof the user interface 505 can vary as well including any of a variety oflights, sounds, vibrations, displays, and other outputs. The feedback ofthe user interface 505 can alert the user and/or provide the user withinformation regarding function, status of the device 400 and itscomponents. The feedback can also provide alerts regarding battery lifeas is known in the art. In some implementations, the device 400 canincorporate a light that is not related to feedback regarding functionof the device. Rather, the device can incorporate an external light onthe lid to illuminate it and the surrounding area. Other user friendlyfeatures can be incorporated on the device as well. For example, thedevice 400 can include one or more attachments that allow the device 400and its attached canister to be positioned in a convenient manner in alocation. Magnets, clasps, hooks, and other features are consideredherein. A strong magnet located, for example, on a back face of thecanister can allow for the device 400 (coupled to a cartridge 413 and awipe canister) to be attached to a magnetic surface. Similarly, a hook(detachable or built-in) can be positioned on a region of the device 400allowing it to be hung near a point of use, for example, from hooks orhorizontal bars. In an implementation, the device 400 can incorporate ahandle similar to a handle on a pail such that a user can convenientlyhold and transport the device 400. The handle can extend out from thebase of the device 400 and be sufficiently long to swing over the top ofthe cartridge 413. Any of a variety of configurations of the handle areconsidered herein and as is known in the art.

The power source 525 can include one or more batteries. The power source525 can be self-contained such that the entire power source 525 can beremoved from the device 400. A power source 525 within the device 400(as opposed to the removable cartridge 413) allows for the device 400 tobe used without a cartridge 413. For example, a user may want todispense a wipe from the device 400 without adding the liquidcomposition from the reservoir 414 of the cartridge 413. For example,the power source 525 can include one or more batteries enclosed in abattery pack that is replaceable and/or rechargeable. The power source525 can be recharged such as by a USB port, induction charger, and thelike. The power source 525 can include rechargeable battery such asNiCad battery, LiPo battery, NiMH battery or the like. In someimplementations, data transfer via a wired USB/Micro USB connection canalso recharge the power source 525 as is known in the art. In someimplementations, the power source 525 can be located within a portion ofthe removable cartridge 413.

The communication port 515 is configured to provide communicationbetween the device 400 and one or more other components. The device 400can communicate with one or more of the cartridge 413, an externalcomputing device 600, or another device 400 in a wired or wirelessmanner. In some implementations, the communication port 515 of thedevice 400 can include a transmitter/receiver configured to communicatewith a corresponding transmitter/receiver on the cartridge 413, device600, or device 400. The communication can be one-way or two-way wirelesscommunication. The wireless communication can include a transmitterand/or receiver, radiofrequency (RF) transceiver, WIFI connection,infrared or Bluetooth communication device. The wireless connection canuse any suitable wireless system, such as Bluetooth, Wi-Fi, radiofrequency, ZigBee communication protocols, infrared or cellular phonesystems, and can also employ coding or authentication to verify theorigin of the information received. The wireless connection can also beany of a variety of proprietary wireless connection protocols. The wiredconnection can vary as well including a RS22 connection, USB/microUSBconnection, Firewire connections, proprietary connections, or any othersuitable type of hard-wired connection configured to receive and/or sendinformation to the external device.

FIG. 2 illustrates an implementation of the device 400 having acommunication port 515 configured to communicate with an externalcomputing device 600. The external computing device 600 can include acommunication port, a controller, and a user interface (such as agraphical user interface or GUI). The communication port 515 of thedevice 400 and also the communication port of the external computingdevice 600 can include a wired communication port. The communication modport 515 and also the communication port of the external computingdevice 600 can alternatively or additionally include a wirelesscommunication port such that information can be fed between the device400 and the external computing device 600 via a wireless link. Theexternal computing device 600 with which the device 400 communicates canvary including, but is not limited to, desktop computer, laptopcomputer, tablet computer, smartphone or other device capable ofreceiving data and running a software program to analyze the data. In animplementation, the external computing device 600 can be a remoteserver.

The communication between the device 400 and external devices allows forthe storage and analysis of such data transmitted. FIG. 3 illustrates animplementation of the device 400 having a communication port 515configured to communicate with an external computing device 600 as wellas at least one other device 400. The data from a single device 400 aswell as aggregate data from a plurality of devices 400 can betransmitted, stored, and analyzed as will be described in more detailbelow. For example, the data can be analyzed by a software program tocalculate wipe usage, duration between dispensing of wipes, batterylevel, device status, device performance, cartridge solution level,number of wipes remaining in a canister, expiration date of deviceand/or cartridge, total run time of a device, wipe data for rooms withoutbreaks, etc. Any of a variety of data can be analyzed for a varietyof reasons as described elsewhere herein. The software program cananalyze the data to extrapolate cost metrics, trends over time, and makepredictions regarding future usage in order to inform ordering andbudget allocation decisions. For example, a first device in a particularlocation (e.g., operating room) may experience heavy use over a certainperiod of time. The devices purchased may need to be greater for thatpurchase period to cover the increase in use to compensate.

The communication between the device 400 and the external computingdevice can also allow for remote wireless control of the device 400. Forexample, a user can use the remote wireless control to adjust functionsof the device 400 such as the speed of the dispensing mechanism 430, orvolume of solution dispensed by the application mechanism 418. Theremote wireless control of the device 400 can allow a user to dispense awipe remotely or disable the device 400 altogether. The speed ofdispensing, volume of solution dispensed, etc. can be adjusted manuallyon the device such as via an input like a button or switch as well as aninteractive touchscreen on the device 400.

As mentioned above, the devices described herein can incorporate one ormore sensors 520 configured to sense various functions of the device400. The one or more sensors 520 can sense various events that occur andcommunicate with the processor 510 such that the processor 510 canmonitor, analyze, record in memory the variety of data points such thatone or more functions of the device 400 can be controlled. Data from theone or more sensors 520 can identify whether and how the device 400 isbeing used (e.g. whether a wipe is dispensed or ready to be dispensed,the number of wipes dispensed, when wipes are dispensed, timing betweenwhen wipes are dispensed, frequency of wipes dispensed over time,whether multiple wipes are dispensed simultaneously, etc). The data fromthe one or more sensors 520 can be communicated in real-time to theprocessor 510, which can analyze the data, display the data, and/orcommunicate the data to an external computing device 600. The data fromthe sensors can be processed into one or more processed signalsrepresentative of how the device 400 is being used, for example, for thepurposes of tracking budget, inventory, efficiency, waste, whethersafety protocols are being followed, etc. The various methods of use aredescribed in more detail elsewhere herein.

In some implementations, the one or more sensors 520 can include asensor configured to identify when a wipe has been dispensed from thedevice 400. The dispensing aperture 416 can contain a mechanical flap orcover 494 configured to cover the aperture 416 (see FIG. 12B). Thesensor 520 can be an optical sensor or another type of sensor positionedrelative to the cover 494 to detect the presence of a wipe within thepassageway of the aperture 416 and cause the system to regulate whetheror not a liquid composition can be applied upon actuation of the input.For example, the cover 494 can swing or be otherwise displaced when awipe is present within the aperture 416. Movement of the door 494 caninterface with the sensor 520. The sensor 520 can communicate with theprocessor 510 upon sensing a wipe, which can cause the processor 510 toinactivate the application mechanism 418 and/or the dispensing mechanism430. For example, the inactivation can result in no liquid compositionbeing dispensed even when the actuator 431 is pressed thereby preventingwaste or drips. The actuator 431 can only dispense the liquidcomposition when the sensor 520 detects a wipe is ready to receive it.Position of the cover 494 relative to the dispensing aperture 416 (e.g.displacement or lack of displacement) can be detected by the sensor 520and information regarding the position communicated to the processor510. The processor 510, in turn, can modulate (i.e. deactivate oractivate) the application mechanism 418 and/or the dispensing mechanism430 such that liquid is dispensed (or not dispensed) onto the wipe uponactuation of the actuator 431. The sensor 520 can prevent inadvertentdispensing and waste of liquid from the device.

Additionally, if no movement of the cover 494 occurs for a selectedperiod of time (e.g., 10 seconds-30 seconds, or 30 seconds-1 minute, or1-2 minutes, or 1-5 minutes, etc.), the gear rollers 438 can turn in anopposite direction away from the aperture 416 to retract the wipe fromthe aperture 416 and back into the lid. Once the cover 494 is no longerdisplaced, the gear roller 438 can stop. The wipe enclosed within thelid prevents inadvertent drying out of wipes. In other implementations,the sensor 520 is an optical sensor that detects the present of the wipehanging out of the aperture 416. Once the wipe is pulled away from theline of sight of the optical sensor, the gear roller 438 can stopretracting the wipe. The device can incorporate more than one sensor.For example, a first sensor configured to detect position of the cover494 and a second sensor configured to detect the wipe hanging out of theaperture 416.

The period of time before automatic retraction of the wipe can beconfigured through software settings. In some implementations, thedevice 400 can be in communication with an external computer running asoftware program. In other implementations, the processor of the device400 itself can run the software program. A user can program and/orinteract with a user interface such as a touchscreen display on thedevice 400 (or the external computer) to set the period of the idle timebefore automatic wipe retraction occurs. Idle time before retractionprogrammed using the software can be a period of seconds (e.g., 10seconds to 59 seconds) up to a period of minutes (e.g., 1 minute toabout 60 minutes). Retraction of the wipe can also be manually activatedsuch as by the user actuating an input on the device 400 to cause thewipe to retract on demand.

The automatic retraction of the wipe described above can coordinate withone or more alerts by the user interface 505 to indicate to a user thewipe is about to be retracted within the device 400. For example, thecomputing system 495 of the device 400 can additionally incorporate atimer. The user interface 505 (which can include one or more lights,displays, or a speaker, etc) can be configured to alert a user prior tothe end of the selected period of time. The timer can also cause thedevice 400 to enter a sleep mode after a period of inactivity topreserve battery life.

Inadvertent drying out of wipes intended to be dispensed wet can lead tothe wipe being insufficiently soaked with fluid to be effective incoating the surface. The device can incorporate features to preventinsufficiently wetted wipes from being dispensed or to alert to the userthat wipes are insufficiently wet, through one or more alerts by theuser interface 505. In some implementations, as the wipes are fedthrough the rollers, the amount of compression of one roller (e.g., thebottom roller) can be used to approximate the mass of the wipe beingdispensed. The weight of the wipe can be used to determine its wetness.A notification such as an alarm or a message displayed on the lid can betriggered if the wipe being dispensed is below a weight threshold thatindicates the wipe is insufficiently wetted. In some implementations,the amount of liquid being compressed out of the wipe as the wipe is fedthrough the rollers can be measured by a scale or detected by a sensor.The scale or sensor can be positioned near the one or more drainageholes (i.e., drainage holes 428) intended to drain excess liquid backinto the canister as the wipe is dispensed. Data regarding weight of theliquid collected can be used to approximate wetness of the wipe beingdispensed.

The computing system 495 can include a counter to monitor and record thenumber of wipes used over a period of time. One method includes countingbased on the amount of time spent actuating an input of the userinterface 505 to dispense the wipes. For example, pressing a button for2 seconds may allow 1 wipe to be dispensed. If the button was pressedfor a cumulative 120 seconds for one day, the data can show 60 wipeswere dispensed that day. The method can also include counting based onthe number of revolutions made by the gear roller 438. For example, ifthe number of revolutions by the gear roller 438 is 4 to dispense asingle wipe, 120 revolutions in a day equals 30 wipes dispensed thatday. Counting of wipes can also be based on an optical sensor positionednear the aperture 416 as described above. The optical sensor mightdetect the perforations between wipes to count how many are dispensed.

The counting data can be synchronized with time logs. When the data isaccessed (e.g. after wirelessly synced into a software program), abreakdown of wipe usage can be performed based on time intervals(hours/shifts, days, months, year, etc). This sort of inventory data maybe useful for a user (e.g., an EVS manager) to monitor how many wipesare being dispensed from a specific device 400 per shift, per week, etc.This data could allow the user to track upticks in wipe usage based onthe season or during outbreaks and adjustment can be made. The data canallow a user to monitor compliance and identify whether staff is usingenough wipes for each room. For example, housekeepers may change theirwipes too infrequently leading to reduced efficacy and transfer ofpathogens between surfaces. Conversely, the data can allow a user todetermine whether too many wipes are being used per room leading tounnecessary waste. The data can allow for estimating inventory needs andbudget allocation. The data can be used for cost-benefit analyses inresearch or financial studies.

The counting data can be useful for tracking inactivity or the durationof time between dispensing wipes. A time log can track when the input isactivated and for how long. This data can provide information regardingfrequency users dispense wipes and whether multiple wipes are dispensedsimultaneously (e.g., 3-4 at a time) or only a single wipe dispensed ata time. The data from the time log can show inactivity betweendispensing of the wipe and the length of those periods of inactivity.This can provide insight into how much time a user takes to use a wipebefore dispensing a new wipe. The data can show whether too few or toomany wipes are being dispensed. This sort of data can be useful forfacilities having a cleaning protocol in place that requires wipes to beused for no more than 3 minutes continuously without changing to a freshwipe. The data can show whether wipes are being dispensed at asignificantly less frequent rate (i.e., every 15 minutes) and alertmanagers to staff errors. In the instance of longer periods ofinactivity (e.g. 1 hours up to 1 day to 1 week), the processor 510 cancause the device 400 to enter sleep mode and turn off non-essentialfunctions in order to preserve battery power. The period of inactivitycan be user-selected depending on how frequently or infrequently adevice 400 is typically used.

In some implementations, the cartridge 413 can include one or moresensors (e.g. near a bottom of the cartridge 413 and reservoir 414)configured to detect liquid volume of the reservoir of the cartridge 413and communicate information regarding the liquid volume to the processorof the device. The device can provide an alert to notify a user whenliquid volume within the cartridge 413 has dropped below a thresholdlevel. The sensor configuration can be an optical sensor or a mechanicalsensor. The sensor of the cartridge 413 can be a float-level sensor. Insome implementations, slot 437 of the device 400 can incorporate asensor that measures mass to determine the liquid volume within thecartridge 413.

The counting data in the log can provide additional informationregarding activity of certain devices 400 and mapped to productivity.The usage of a device 400 can help a user determine whether cleaning isbeing handled inefficiently and according to protocol. The data can helpto identify any of a variety of activity patterns and whether too manybreaks are taken in between rooms, as well as inefficiencies in: thelay-out of the rooms, which rooms a particular user is assigned toclean, where the supply closet is located, poor performance fromunmotivated staff, long lunch breaks, etc.

As mentioned above, data from the device can be analyzed by softwareprograms to calculate various data points (e.g., wipe usage, durationbetween dispensing of wipes, number of wipes remaining in a canister,total run time of a device, etc.) The software program can be adapted totake into account details about the wipe that is being dispensed fromthe canister to improve the accuracy of these calculated data points. Asan example, different wipes can have different dimensions and thedifferent wipe dimensions can impact a user's understanding of the data.As an example, PDI Sani-Cloth Bleach wipes can have a shorter length(e.g., 6.5 inches) compared to the length of a Clorox HealthcareGermicidal Bleach wipe (e.g., 12 inches). The specific type of wipecontained within a canister and/or the length of the wipe beingdispensed can be used in the calculation of the time needed to dispensea single wipe.

The device can detect certain brands of wipe such that the calculationsof the various data points are adjusted depending on which canister ofwipe the lid is coupled to. The method of detecting the different brandsof wipe can vary including sensors on the device 400, the adapter 700,and/or the canister. As an example, the device 400 can include a sensornear its lower end region where the device 400 and the canister couplethat is configured to interface with one or more feature of the wipecanister to provide information regarding the wipe to be dispensed fromthe canister. Similarly, a sensor 705 can be positioned on the adapter700 coupling the device 400 to the canister. The sensor 705 can vary inconfiguration including mechanical, electronic, optical, magnetic, orother form of sensor. In some implementations, the sensor 705 is amechanical switch or button. In other implementations, the sensor 705 isconfigured to interface with or detect a readable code. Differentmanufacturers of different types of wipes may incorporate slightdifferences between the wipe canisters that can be detected by thesensor of the device 400 or adapter 700 when the device 400 is attachedto the canister. For example, manufacturers may elect to include atactile series of ridges and bumps, notches, RFID tags, etc. todifferentiate their wipes to be read by sensor 705. The sensor 705 cancommunicate information about the wipe canister to the processor of thedevice 400, which in turn can be programmed to automatically adjust thedevice mechanics based on the detected differences, for example,changing motor speed, volume dispensed, etc. to compensate for thedifferences in wipes being dispensed through the device 400. In someimplementations, the sensor 705 near the lower end of the device 400(FIG. 15 ) or the adapter 700 (FIG. 14A-14C) can be a mechanical rod oran electronic sensing element that informs the computing system of thedevice 400 that the wipes held in the canister are larger in size and/orbeing dispense from a larger canister size. The information detected bythe sensor 705 of the device (or on the adaptor) provided by thecorresponding feature (e.g. the code) on the canister can vary.

FIGS. 14A-14C illustrate an implementation of a sensor 705 positioned ona region of the adapter 700. The adapter 700 can include an upper lip701 that is sized and shaped to interface with a lower end region of thedevice 400. The sensor 705 can be a mechanical feature positioned on aninner surface of the upper lip 701 such that when the upper lip 701encircles the lower end region of the device housing, the sensor 705physically engages with the device housing. Alternatively, the sensor705 can be positioned on an inner surface of the bottom ring 433 of thedevice 400 configured to surround and engage with an upper rim of acanister (see FIG. 15 ).

Again with respect to FIGS. 1B, 2, and 3 , the cartridge 413 and thedevice 400 may communicate with one another by incorporation of a dataelement 424 on the cartridge 413 configured to be in communication withthe communication port 515 of the device. As an example, the dataelement 424 can store data about the cartridge 413 such as contents,volume, date of manufacture, the intended brand of and size of wipe thecartridge 413 is to be used with, as well as any other informationregarding the cartridge 413. The data can be stored within the element424 and communicated to and received by the processor 510 of the device400 upon “reading” the element 424 on the cartridge 413. Theidentification of the cartridge 413 can be initiated automatically bysoftware run by the processor 510 of the device 400. The data element424 of the cartridge 413 can include an encoder or bar code type stripconfigured to be scanned and read by a corresponding reader device ofthe device 400 that is in operative communication with the processor510. The data element 424 may alternatively be an RFID chip, physicalfeatures such as bumps, ridges, or notches that can be detected or readby device 400, or the like that transmits data to a reader such as adata receiving processor or the like. Such encoder devices include theability to securely transmit and store data, such as, via, encryption,to prevent unauthorized access or tampering with such data. Therecognition of the element 424 also ensures genuine cartridges and/orthe correct cartridge is installed with the device 400. For example, theelement 424 can identify the contents of the reservoir and the device400 can be programmed to ensure the content of the reservoir 414 issuitable for the type of wipe contained in the canister C. For example,the formula in the reservoir 414 of the cartridge may be suitable for aPDI bleach wipe with a 4 minute fading time or a Clorox bleach wipe witha 3 minute fading time, etc. Indicator compositions for differentdisinfectant wipes may require a particular volume be dispensed from thecartridge 413 in order to achieve the appropriate final formulation. Forexample, a bleach wipe may have a particular indicator compositiondispensed at a certain volume (e.g., 1.5 mL) to achieve the proper finalformulation for use. A quat/alcohol wipe may have a different indicatorcomposition dispensed at a smaller volume (e.g., 0.75 mL). Communicationbetween the cartridge 413 and the device 400 identifying what liquidcomposition is contained within the reservoir 414 and/or what type ofwipe is contained within the canister can allow for the device 400 toautomatically adjust the dispensing of that solution, for example, byadjusting the flow rate, volume, and/or wipe dispensing speed asappropriate to achieve a particular final formulation. The adjustmentcan be achieved mechanically such as via buttons, switches orelectronically. It is useful for the device 400 to “read” the cartridge413 to ensure proper setup before use. Other data can be containedwithin the element 424 such as a starting solution volume, expirationdate, etc. The device 400 can be prevented from dispensing a solution toa wipe if the solution is determined to be incompatible. The data can bestored to track what solutions are used with which wipes, when they areinstalled together, whether used in its entirety, and whether the samedevice 400 is used with another type of wipe canister, etc.

In some implementations, wipe manufacturers can build readable features(mechanical, magnetic, optical, electronic, etc.) near the upper rim ofthe canister. Upon coupling the device 400 to the canister, the featurecan trigger (e.g., by the mechanical sensor 705 or switch on the device400 or adapter 700) automatic adjustments in the mechanics of the device400 to accommodating the differences in the wipe contained in thecanister. For example, a manufacturer of one type of disinfectant wipesmay have one notch on the rim of the canister whereas a manufacturer ofa different type of disinfectant wipes may have two notches on thecanister rim. When the device 400 is mounted onto these differentcanisters, the device 400 can detect based on the presence of thenotches the brand of wipe. The cartridge 413 can be customized for thebrand and/or size of wipe as well.

One or more codes can be incorporated into a part of the cartridge 413or into part of the canister that can be detected and “read” by acorresponding sensor on the device 400. The readable features can bemechanical, magnetic, optical, or electronic. For example, the cartridge413 can include a data element 424 as described above. In otherimplementation, the one or more codes can be a tactile series of ridgesand bumps, similar to Braille, that form a code detected by the sensorof the device 400. The code detected by the sensor can provideinformation about the wipe contained in the canister (or the cartridge413). As an example, a first section of code can delineate wipechemistry, a second section of code can delineate wipe dimension, and athird section of code can delineate a further wipe dimension, and so on.The first section of code can be a single horizontal line indicating thewipe is a bleach wipe or two horizontal lines indicating the wipe is ahydrogen peroxide wipe, etc. The second section of code can be a numberof shapes indicating a width of the wipe. For example, six circles canindicate the wipe is six inches wide. The third section of code can be anumber of a different shape indicating a length of the wipe. Forexample, ten squares can indicate the wipe is ten inches long.

The above are just examples of codes considered herein and is notintended to be limiting. Any of a variety of codes can be incorporatedto communicate information between the components of the systemsdescribed herein as is known in the art. The communication of databetween the device 400 and the canister and/or the cartridge 413 and thedevice 400 need not be automatic, but can also be manually inputted. Forexample, the device can incorporate a touchscreen or dedicated input toprovide information related to the wipe dimension and/or chemistry.

The memory of the computing system 495 can be configured to maintain arecord for a particular cartridge 413 and/or device 400. For example,the record can indicate when the cartridge 413 or device 400 is beyondits expiration date. Once a cartridge 413 and/or device 400 has reacheda particular threshold, the software can be configured to write onto thememory of the data element 424 of the cartridge 413 such that uponsubsequent use, the device 400 is alerted to the information that thecartridge 413 should not be used. Thus, information can be sent betweenthe device 400 and the cartridge 413 in a two-way manner.

The cartridge 413 may also include one or more other sensing mechanismsconfigured to monitor the volume of solution within the reservoir 414over time. The sensor(s) of the cartridge 413 can communicate such datato the processor 510 of the device 400 such that when the reservoir 414is near to empty that information can be relayed to a user from thedevice 400. The processor 510 can be configured to activate one or morealerts such as a sound, a light, or other sort of display on the userinterface 505 to indicate to the user the cartridge solution is runninglow and the cartridge 413 needs to be replaced. The sensor can be anoptical sensor or a circuit chip that estimates volume levels within thereservoir 414 based on how much time it has spent dispensing solution,etc. Other sensors can be incorporated within the device 400 to trackand display the approximate level of wipes remaining in the canister(i.e., weight or optical sensors).

In an implementation, a sensor in the base of the device 400, such as anoptical sensor, can detect a dimension of the wipes remaining in thecanister such as a diameter/radius of the wipe log. The measureddimension indicates how many wipes remain. For example, a wipe log witha radius of about 1 inch can be estimated to have 20 wipes left. Thewipe log dimension can be calibrated based on a measured dimension priorto dispensing the first wipe in the log and the number of wipes known tobe in the wipe log. The sensor in the base of the device 400 can also beconfigured to detect weight of the wipe log. The number of wipesremaining can also be calculated based on the number of wipes in a wipelog upon loading the wipe log in the canister minus the number of wipesdispensed through the device.

In still further implementations, an assembly formed by the device 400having a cartridge 413 loaded therein and fastened onto a wipe canistercan be mounted on a wall mount. The wall mount can include a sensor anda communication unit configured to communicate with the device 400. Thesensor of the wall mount can be configured to assess weight of theassembly and relay that information to the device 400. The informationcan be used to estimate how much volume and how many wipes remain in theassembly. For example, an assembly including a new cartridge 413installed within a device 400 that is attached to canister of wipes mayhave a starting weight of about 8 lbs. If 50% of the wipes of theassembly are consumed, the assembly may weigh 5.5 lbs. If 100% of thewipes of the assembly are used (i.e. no more wipes in the canister), theassembly may weigh only 3 lbs. The weight sensor in the wall mount cancommunicate to the device 400, which in turn may notify a user, when theweight of the assembly drops below a set lower threshold. The lowerthreshold may be when all the wipes are all consumed (e.g. weighs 3 lbsin the scenario described above). The lower threshold may be when thewipes are low, but not completely gone (e.g. weighs 3.1 lbs in thescenario described above).

In a further implementation, a moisture sensor can be positioned withinthe canister such that when the moisture content within the canisterfalls below a certain threshold indicating the wipes are nearly dry, thesensor can communicate information to the device 400 to alert the user.Any of a number of sensors can be incorporated within the cartridge 413,the device 400, the wall mount, and/or the canister holding the wipes.

The computing system 495 can collect data (e.g. from one or more sensors520) related to the performance and internal mechanics of the device400. For example, the speed of the drive motor 434 for the feed system,torque of gear rollers 438, performance of the pumping element 463, thevolume of solution dispensed, battery life, etc. can all be monitored bythe computing system 495. The data can be used for calibration ormaintenance purposes. If, over time, certain functions of the device 400change (e.g., gear rollers 438 rotate more slowly or undergo an increasein torque, or the volume of solution dispensed decreases due to pumpingelement malfunction or clogging), adjustments can be made to compensate.Or, if adjustments do not fix the problem, the device 400 can alertusers that maintenance/repairs are needed. The device 400 can alsomonitor the expiry of a device 400 and/or cartridge 413. For example,upon first installation of a device 400 with a canister of wipes a timelog entry can start a countdown in time (i.e. days, months, years)and/or in number of wipes dispensed from a particular device 400. Thedevice 400 can then provide a user alert regarding an expiry of ashelf-life period or when a maximum number of wipes has been dispensedbefore optimal performance is no longer expected. The user alerts canvary including a displayed message, a sound, a blinking light, and thelike to alert a user of various information regarding the device 400,the cartridge 413, and/or the wipes within the canister. For example,the alert can be triggered to notify the user when a cartridge or wipecanister should be replaced, approaching a shelf life of a particulardevice or canister of wipes, when a maximum number of wipes has beendispensed, etc.

As described herein, the devices 400 described herein can communicatewirelessly to a remote location such as an external computing device600. That communication can provide information regarding the physicallocation of the device 400. The location data can be such that a device400 is linked to a particular patient room, a floor, wing, or departmentwithin a building. The location data can be tracked via software such ason a remote computing device or server. Location data may be useful to amanager of a facility to keep track of where the devices 400 are locatedwithin a particular facility and whether distribution of devices withinthat facility is acceptable. For example, when using a software programto monitor the location of all devices 400 in a particular facility, amanager may notice that several devices were moved from one wing ordepartment to another wing or department, which could leave that regionwithout sufficient devices to meet the need. The manager can the moreeasily redistribute the devices 400 throughout the facility.

Tagging the devices 400 by location may allow the manager to monitorwipe usage in rooms with outbreaks. For example, if a patient in oneroom suffers an outbreak (e.g., C. difficile), the manager may lookspecifically at data transmitted by the device 400 at that particularlocation to inform the manager how many wipes may have been dispensedand used to disinfect the room at the time of the outbreak. This canhelp to correct breaches in protocol and/or to adjust cleaning habitsaccordingly. Additionally, upon an outbreak of a highly contagiouspathogen such as C. difficile, the device 400 is preferably quarantinedto that room or disinfected thoroughly before being moved out of theroom. The device 400 can be “tagged” as having been located within abreakout room such as by a light, alert, or other switch or monitorsystem can be toggled back to an off position after fully disinfecting.Such location tracking also can help to identify stolen or misplaceddevices 400. This may prompt a user to remotely disable the device 400.

A plurality of communication units within a facility can create a“geofence” that allows for instant alerts and/or disabling of devices400. If a device 400 is detected to be located more than a thresholddistance outside the geofence for a minimum threshold period of time,the device 400 can be flagged as “stolen” and be remotely disabled. Thethreshold distance and threshold period of time can vary and can beprogrammed by a user. As an example, the threshold distance can be atleast about 10 feet outside the geofence and the threshold period oftime can be 10 minutes since the device 400 was last detected. In someimplementations, the geofence can be created by mounting a plurality ofcommunication units within a facility such that each of the plurality ofcommunication units tracks device activity in relationship to a specificlocation such as a specific hospital room. The communication unit can bemounted above the door of the room, for example, and flag when a device400 enters and exits the room. This configuration allows for tracking ofthe devices 400 in a more specific manner on a room-by-room basis. Theroom-by-room tracking can also provide information as to whether oneroom has been skipped (i.e., no device 400 entered a particular room) orwas left inside a room (i.e., the device 400 that entered the room didnot exit the room). The computing system 495/600 can be programmed touse this information to determine an amount of time each device 400 waslocated inside each room for quality control auditing and/or workflowmanagement purposes.

In other implementations, a communication unit can be mounted outside adoor of a particular patient room. The unit can detect a device 400 asbeing within a particular radius (e.g., within a 5-foot radius) for aminimum threshold period of time (e.g., 30 seconds). The communicationunit can detect a device 400 has met the thresholds and can tag thedevice 400 as having entered that particular room. This configurationallows for the scenario where a worker may clean a room with a wipe, butmay not carry the canister of wipes into the room to perform thecleaning. A device 400 coupled to the canister may be left outside ofthe room, but within the minimum threshold radius for at least thethreshold period of time and be tagged as having been used for thatroom.

In still further implementations, the communication unit can be embeddedon a wall canister mount located outside a patient room. Thecommunication unit can detect and track the presence or absence of a liddevice 400 inside the wall mount. This configuration may be useful totrack how often the lid device 400 is removed from the wall mount, forexample, to replace a used canister with a fresh canister. Thisinformation can also be useful to assess whether a wall canister mountis empty and needs a new canister and lid device. The information can beused to identify when a particular canister of wipes (e.g., bleachwipes) should be replaced due to passing of an expiration date. Thelocation tracking described herein can use Bluetooth, Wi-Fi, and/or GPSsignaling.

Generally, disinfectant wipes require a certain contact time to fullyinactivate pathogens on a surface. The device 400 can include a timerfunction that provides a visual and/or audio cue for users to keep trackof elapsed time of contact. In some implementations, a countdown maybegin at the time the wipe is dispensed and an alert after a time periodidentify the expiration of that time period. The user interface 505 canalso display the countdown time. More than a single timer can beincorporated as well.

Any of a variety of features can be incorporated in the devicesdescribed herein. As described above, the computing system 495 caninclude a microphone. User queries or commands can be provided to thecomputing system 495 via the microphone. In some implementations, theprocessor 510 is programmed to provide coaching or guidance regardingwhat sort of disinfectant wipe is needed for a particular pathogen andcan response to a query with such programmed information. As an example,a user can ask what type of disinfectant wipe is needed to treat aparticular pathogen (e.g., C. difficile). The computing system 495 canrespond via a speaker of the user interface 505 with the answer alongwith information regarding whether the device 400 contains appropriatewipes (e.g., “bleach wipe”). The speaker of the user interface 505 canalso provide other audio instructions from the device 400.

As another example, a user can ask what contact time is optimal for theparticular pathogen (e.g., C. difficile). The computing system 495 canrespond via the speaker of the user interface 505 with the answer alongwith information regarding whether the device 400 contains appropriatewipes (e.g. “bleach wipe takes 3 minutes of contact time”). The user canask any of a variety of questions such as which surfaces should be wipedin a certain type of room (e.g., inpatient room vs. operating room),what types of surfaces or equipment are compatible with certain types ofdisinfectants (e.g., “Is X machine compatible with bleach wipes?”), andabout their own performance metrics (e.g., average number of wipes perroom, time spent per room, etc.).

Optic sensors in a room or area or on device 400 can be incorporated totrack color indicator on a particular surface and alert a user when thesurface(s) is successfully disinfected. A camera system or full-roomoptical sensor system can be used to monitor the surfaces successfullywiped (e.g., initial color for coverage, and then when color indicatorhas faded indicating completion of disinfection). The data regardingsuccessful disinfection can be tracked in a room-by-room mannerproviding information regarding thoroughness of cleaning. For example,the camera system can link with the device 400 in a wireless manner andcommunicate the information to a central server, for example, which inturn can store the data for analysis. For example, lid device A in roomA tracked 75% of high-touch surfaces were cleaned whereas lid device Bin room B tracked 95% of high-touch surfaces were cleaned, etc. Thecamera or optical sensor system can detect whether a surface was missedwithin a period of time after initiation of cleaning and alert a userwith a visual or audio reminder with that information (e.g., nodisinfectant was applied to a desk table within 5 minutes of the firstwipe being dispensed in the room.

In some implementations, a cartridge 413 can be configured to dispense amixture at the point-of-use. The mixture can include a mixture of dyesthat can provide any of a variety of colors useful for identifying atreatment. The dyes can be primary colors that when combined produce asecondary color (e.g., a blue dye and a yellow dye combine to make agreen color when spread or wiped onto a surface). The combined dyes canhave different fade times, for example, a first dye that fades in 1minute and a second dye that fades in 3 minutes, etc. Fading of one ofthe two dyes can result in the secondary color turning back into theprimary color due the first dye fading faster than the second dye. Thesequential fading of mixtures of dyes provides additional indication tothe user about how much time has elapsed. As an example, the first dyecan be yellow having a fading time of 1 minute and the second dye can beblue having a fading time of 3 minutes. When the yellow and blue dyesare combined at the point-of-use and are applied to a surface fordisinfection, they provide a green color. After a first period of time(e.g., 1 minute), the yellow dye fades away causing the surface to turnfrom green to blue. After a second period of time (e.g., 2 minutes), theblue dye fades to colorless. Once the blue dye fades to colorless, theuser understands that 3 total minutes has elapsed since the wipe wasinitially applied.

Disinfectant wipes can be used that have different contact times fordifferent pathogens. For example, some bleach wipes may specify 1 minutecontact time for norovirus and a 3 minute contact time for C. difficilespores. Therefore, a healthcare worker that is disinfecting a room witha known norovirus outbreak can confirm the appropriate amount of timefor disinfecting for norovirus because the initial green color fades toblue, while a worker disinfecting a room with a known C. difficileoutbreak will wait for the green to fade to colorless. Other colorcombinations are considered herein provided there is a visible changefrom an initial color (e.g., color A) to a second color (e.g., color B),and finally to colorless. Additional color stages are considered aswell. For example, the dispensing cartridge may contain four dyes timedto fade after 30 seconds, 1 minute, 2 minute, and 3 minutes. Anywater-soluble dye that may allow successive fading times and visibilitymay be used. Additionally, pH dyes may be used in the disinfectantsolution.

Any of a variety of formulations can provide the timed functionalitydescribed above. For example, indigo carmine in combination with FDC Red40 may provide an initial color that is purple. FDC Red 40 can be at alighter concentration to fade faster than indigo carmine such that thepurple turns to blue within a first period of time (e.g., 1 minute) andafter a second period of time (e.g., 3 minutes), the remaining indigocarmine fades to colorless. Different dyes can be selected based onwhich are sensitive or resistant to bleach oxidation.

Compositions for use with the devices described here, and relatedmethods, are described in more detail in the following sections.

Compositions and Methods

The present disclosure provides additional and improved indicatorcompositions relative to those disclosed in the inventors' earlier workpublished as WO 2018/022621, the contents of which are herebyincorporated by reference in their entirety. The compositions describedhere further take advantage of certain additional and improved featuresof the devices described here to provide improved performance andflexibility in surface disinfection and decontamination.

The present disclosure provides single and multi-component indicatorcompositions which impart a visible color to a disinfectant composition.In some implementations, the single and multi-component indicatorcompositions comprise a colorant and a catalyst, which catalyst may beprovided by the disinfectant composition, or may form a component of theindicator composition, and one or more optional additives. The one ormore optional additives may be selected from an alkyl amine, ananticaking agent, an anti-foaming agent, an antimicrobial agent andpreservative, an antioxidant, a butter, a chelating agent, aco-emulsifier, a co-surfactant, a copolymer, a corrosion inhibitor, anemollient, an emulsifying or dispersing agent (these terms are usedinterchangeably), an emulsion stabilizer, a filler, a foaming agent(interchangeable with foam-boosting agent), a humectant, amoisture-absorbing agent, an occlusive, an oil, an opacifying agent, anoleochemical, an organic acid, a pearlizer, a perfume or fragrance, apolymer, a rheology modifier, a silicone, a silicone conditioner, astabilizer, a stabilizing salt, a surfactant, a texturizer, a vitamin, awax, and combinations or mixtures thereof, each of which is described inmore detail below. In some implementations, the one or more optionaladditives includes at least one or both of a surfactant and a rheologymodifier. The terms “thickener”, “thickening agent”, “viscositymodifier”, “viscosity regulator” and “rheology modifier” are usedinterchangeably herein. In some implementations, the optional additivemay comprise a pH modulator such as an acidic agent, an alkaline builderor base, or a suitable buffer system adapted to maintain a desired pH,which may be an acidic or basic pH, as described in more detail below.In some implementations, the optional additive may comprise adisinfectant.

The disclosure also provides methods for disinfecting a surface thatcomprise a step of combining (i) a single component indicatorcomposition as described here with a disinfectant composition or (ii)the various elements of a multi-component indicator composition to forma single indicator composition that is mixed with a disinfectantcomposition to impart a color thereto, both methods further comprising astep of applying the colored disinfectant composition to a surface andallowing the colored disinfectant composition to remain in contact withthe surface for a period of time until the color has faded to clear,thereby disinfecting the surface. In some implementations the surface isa porous or nonporous surface, for example a woven or non-woven fabric,concrete, steel, wood, ceramic, polypropylene, plastic, glass, metal, orgranite. In some implementations, the surface is skin, for example, auser's skin where the indicator composition is in the form of a liquidor gel, such as an alcohol-based disinfecting hand gel. In someimplementations, the surface is not the inside of a toilet bowl.Depending on the intended use and the disinfectant composition to becolored, the component indicator compositions can be adapted to impartcolor to the disinfectant composition which fades to clear afterapplication to a surface over a period of time ranging from 5 seconds to30 minutes or from 5 seconds to 60 minutes, for example from 5 to 120seconds, or from 2-5 minutes, or from 5-10 minutes, or from 10-30minutes, or from 10-60 minutes.

In some implementations, the at least one colorant of an indicatorcomposition described here is a water-soluble oxidizable dye, preferablyselected from an azo dye, a triarylmethane dye, a phenol dye (e.g.,3-nitrophenol), a cationic dye (also referred to as a “basic” dye), ananionic dye (also referred to as an “acid” dye, e.g., alizarine blue andacid red), a thiazine dye, an indigoid (e.g., indigo carmine), and aleuco dye (e.g., indigo, crystal violet). Azo dyes are organic compoundsbearing the functional group R—N═N—R′, in which R and R′ are usuallyaryl. Triarylmethane dyes are synthetic organic compounds containingtriphenylmethane backbones and include methyl violet dyes, fuchsinedyes, phenol dyes (e.g., phenolphthalein, phenol red, chlorophenol red,cresol red, bromocresol purple, bromocresol green), malachite green dyes(e.g., malachite green, brilliant green, brilliant blue), and victoriablue dyes. Thiazine dyes contain a thiazine ring, which is asix-membered ring of four carbons, a nitrogen and a sulfur (e.g.,methylene blue, phenothiazine, thiomorpholine). The colorant may bepresent in any amount suitable to impart the desired color to thedisinfectant composition.

In some implementations, the at least one colorant of an indicatorcomposition described here is soluble in a polar or nonpolar solvent,such as an alcohol or dichloromethane. In some implementations, the atleast one colorant of an indicator composition described here is in theform of an emulsion in aqueous solution or non-aqueous solution (e.g.,oil-in-water emulsions, water-in-oil emulsions, silicone-in-wateremulsions, oil-in-silicone emulsions, water-in-silicone emulsions, andsilicone-in-oil emulsions). Such emulsions of the colorant(s) areadvantageous for combining a colorant that is insoluble or poorly watersoluble, such as crystal violet lactone, with catalysts and optionaladditives that are also insoluble or poorly water soluble, such asocclusives, waxes, butters, and oils, but which provide desired colorintensity and color-fading properties. In some implementations, thedesired color intensity is dark enough to visibly see the color on darksurfaces (e.g., brown, navy blue, etc.) and the desired color-fadingproperty is such that the intense color completely fades to colorlessafter a period of time, leaving behind no visible color residue afterthe indicator composition has evaporated from the surface. Furtherexplanation of the optional additives and their advantages are describedbelow.

In some implementations, where the catalyst forms a separate componentof a multi-component indicator composition described here, the catalystmay be selected from a strong base, a weak base, a combination of strongand/or weak bases, a metal salt, a reducing agent, and an additionalamount of a disinfectant composition, such as additional hydrogenperoxide. In some implementations, where the catalyst may form aseparate component of a multi-component indicator composition describedhere, the catalyst may be selected from a strong base, a weak base, acombination of strong and/or weak bases, a metal salt, a reducing agent,an oxidizing agent, a strong acid, a weak acid, a combination of strongand/or weak acids, and an additional amount of a disinfectantcomposition, such as additional hydrogen peroxide. In someimplementations, the catalyst may comprise a reactive oxygen speciesgenerating agent, for example, sodium nitrate, potassium nitrate, sodiumnitrite, and titanium dioxide. In embodiments, the total amount ofcatalyst in the composition is 3-40% w/w, preferably 3-10% w/w, based ontotal weight of the composition. In embodiments, the ratio of catalystto water-soluble pigment in the composition is from 0.005:1 to 20:1 orfrom 0.50:1 to 5:1. In some implementations, the indicator compositionmay comprise one or more catalysts.

In some implementations, the one or more catalysts comprises a strongbase selected from potassium hydroxide (KOH), sodium hydroxide (NaOH),lithium hydroxide (LiOH), rubidium hydroxide (RbOH), cesium hydroxide(CsOH), calcium hydroxide (Ca(OH)₂), strontium hydroxide (Sr(OH)₂),magnesium hydroxide (Mg(OH)₂), and barium hydroxide (Ba(OH)₂),preferably KOH, NaOH, LiOH, or Ca(OH)₂.

In some implementations, the one or more catalysts comprises a weak baseselected from a base having a pK_(b) of less than 7, preferably anybicarbonate salt, any carbonate salt, methyl amine, hydroxides ofquaternary ammonium cations or other organic cations, pyridine, aniline,imidazole, histidine, benzimidazole, a phosphazene base, and anucleobase.

In some implementations, the one or more catalysts comprises a metalsalt in which the metal salt has an oxidation state of +1, +2, or +3,preferably +2. In some implementations, the metal salt is an iron,copper, zinc, or magnesium salt, preferably an iron salt. In someimplementations, the metal salt is a sulfate, nitrate, bromide,chloride, gluconate, sulfide, fumarate, oxide, iodide, fluoride,acetate, oxalate, stearate, diethyldithiocarbamate, ethoxide, citrate,trifluoromethanesulphonate, or cyanide salt. In some implementations,the metal salt is a sulfate, nitrate, bromide, chloride, or fluoridesalt. In some implementations, the metal salt is anhydrous or hydrated,preferably a mono-, di-, tri-, penta-, hexa-, hepta-, nona-hydrate salt.In implementations where a weak metal salt catalyst is used, such ascopper, zinc, or magnesium, the composition may further comprise anoptional reducing agent which serves to replenish the metal catalyst byreturning it to a lower oxidation state.

In some implementations, certain surfactants may act in a dual role ascatalysts via the generation of hydroxyl radicals, for example,cetylmethylammonium bromide (CTAB).

In some implementations, a single or multi-component indicatorcomposition described here may contain an optional surfactant or mixtureof surfactants. In some implementations, the surfactant is selected fromone or more of an anionic, nonionic, cationic, zwitterionic, amphoteric,or polymeric surfactant. In some implementations, the surfactant isselected from one or more of a nonionic surfactant, such as a polyglycolether (e.g., Tergitol™), tetramethyl decynediol (Surfynol™) andcocomonoisopropanolamide (Ninol™ M10); an anionic surfactant such asalkyldiphenyloxide disulfonate (Dowfax™ 2A1), sodium lauryl sulfate(SLES), and Stepanol™ WA-100; a cationic surfactant such ashexadecyltrimethylammonium bromide (HTAB), which may also be referred toas cetylmethylammonium bromide (CTAB); a zwitterionic or amphotericsurfactant such as lauryldimethylamine N-oxide and cocoamidopropylbetaine; and a polymeric surfactant such as polysiloxane,cetyldimethicone copolyol, and poly-glycerol-poly-ricinolate. In someimplementations, the surfactant is sodium xylene sulfonate (SXS) orsodium toluene sulfonate (STS). In some implementations, the surfactantis a mixture of SXS and STS.

In some implementations, where a surfactant may cause instability in thedisinfectant composition, (e.g., HTAB), and in some implementations,where a surfactant may cause instability in the colorant composition,(e.g., SDS, SXS, SLES), it is especially advantageous to add thesurfactant to the disinfectant and/or colorant composition only at thepoint of use, for example by inclusion in a single or multi-componentindicator composition as described herein.

Further examples of anionic surfactants considered herein include, butare not limited to, sodium dodecyl sulfate (SDS), sodiumdodecylbenzenesulfonate (SDBS), sodium cocyl glutamate, sodium laurylglucose carboxylate, sodium alkane sulfonate, sodium myreth sulfate(SMS), sodium cholate, alkyldiphenyloxide disulfonate,1,1′-oxybis-tetrapropylene derivatives, sulfonated, sodium salts (e.g.,DOWFAX™ 2A1 blend), sodium toluene sulfonate (STS), alkylbenzenesulfonates, di-alkyl sulfosuccinate, sodium stearate, sodiumcocoamphoacetate, sodium lauroyl lactylate, or combinations thereof.Further examples of nonionic surfactants considered herein include, butare not limited to, glycerin, polysorbate 20, polysorbate 80,n-octylpyrrolidinone, an acetylenic diol (e.g., Surfynol 104S), benzene,Brij 721, Triton X 100, Tergitol™ 15-S-15, Tergitol™ 15-S-20, Tergitol™15-S-9, Tergitol™ 15-S-30, glyceryl monostearate, glyceryl monooleate,lauryl glucoside, decyl glucoside, ceteareth-20, or combinationsthereof. Further examples of cationic surfactants considered hereininclude, but are not limited to, benzalkonium chloride, octenidinedihydrochloride, or combinations thereof. In some implementations, theindicator composition includes a surfactant blend of decyl glucoside andsodium lauroyl lactylate. In some implementations, the indicatorcomposition includes a surfactant blend of sodium cocoamphoacetate,glycerin, lauryl glucoside, sodium cocyl glutamate, and sodium laurylglucose carboxylate. In some implementations, the indicator compositionincludes a mixture of different isopropanolamides of cocoamide.

In some implementations, a single or multi-component indicatorcomposition described here may contain an optional rheology modifier orthickener. In some implementations, the indicator composition maycomprise one or more rheology modifiers or thickeners. As with manyadditives, rheology modifiers or thickeners may cause the disinfectantsolution to become unstable over time (e.g., rheology modifiers such asgums and polysaccharides are reducing sugars that react with oxidizerslike hypochlorite, reducing the potency of the disinfectant), which ismitigated by inclusion of the rheology modifier or thickener into asingle or multi-component indicator compositions as described herein,which is combined with the disinfectant composition at point of use, forexample dispensed directly onto a disinfectant article, such as a wipe.

Examples of rheology modifiers or thickeners that may be used includelambda carrageenan, iota carrageenan, kappa carrageenan, sodiumalginate, guar gum, glycerol or glycerin, dextran, cellulose, sorbitol,propylene glycol, lactic acid, lithium chloride, polydextrose, sodiumpolymetaphosphate, sodium polyacrylate, sodium chloride, glucose, agar,starches, gum arabic, pectin, gum polysaccharides, fumed silica, talc,and carbomer, butylene glycol, propanediol, lecithin, sorbeth-230tetraoleate, decyl glucoside, sorbitan laurate, PEG-120 methyl glucosedioleate, methyl gluceth-10, corn starch, triethanolamine, carbomer 940,copolymers (e.g. octylacrylamide, polyacrylic acid, methylacrylic acid),glyceryl stearate, glucose-D, glucose-SORB, glyceryl oleate, orcombinations thereof. In some implementations, the rheology modifier orthickener is glycerol or glycerin. In some implementations, the rheologymodifier or thickener is chloride salts (e.g. sodium chloride), cetearylalcohol, carbomers (e.g., carbomer 920), or combinations thereof. Insome implementations, the rheology modifiers have the additional benefitof acting to fade the dye more quickly, thus allowing fade time to becontrolled (e.g., acrylates/octylacrylamide copolymer), the additionalbenefit of acting as a humectant (e.g., glycerin), the additionalbenefit of acting as a surfactant (e.g., glyceryl mono oleate), theadditional benefit of acting as an oil (e.g. cocamide), the additionalbenefit of acting as a pH adjuster (e.g., Carbomer™ 940), and theadditional benefit of acting as an emulsifier (e.g., glyceryl stearate).

In some implementations, a single or multi-component indicatorcomposition described here comprises a pH modulator in the form of anacidic agent which imparts an acidic pH to the aqueous solution of thecomponent comprising it, for example a pH less than 7, preferably a pHless than 5, or a pH of about 3 or less. In some implementations, amixture of pH modulators may be used. In accordance with any of theimplementations comprising an acidic agent, the acidic agent maycomprise a strong acid, a weak acid, an acidic buffer, or a combinationthereof, for example a zwitterionic compound, a strong acid and weakacid, and/or a weak acid and a conjugate base. In some implementations,the strong acid is selected from one of or a combination of H₂SO₄, HCl,HBr, HI, HClO₄, HClO₃, or HNO₃, preferably H₂SO₄, HNO₃, and/or HCl. Insome implementations, the weak acid is an acid having a pK_(a) of lessthan 7, preferably weak ionic acids and organic acids, preferably anyamino acids, citric acid, acetic acid, ascorbic acid, benzenesulfonicacid, benzoic acid, folic acid, and polyphosphoric acids, andderivatives thereof.

In some implementations, the pH modulator is selected from a basic agentsuch as methylamine, pyridine, diethylamine, hydroxylamine, hydrazine,aniline, aluminium hydroxide, sodium phosphate, sodium carbonate, sodiumbicarbonate, triethanolamine, sodium tripolyphosphate, imidazole,aqueous ammonia, basic buffers with a pH between 7-14, and mixturesthereof. In some implementations, the pH modulator can also act as anagent to produce faster fading of our colorant additive, for exampletriethanolamine. In some implementations, the pH modulator can also actas a solubilizing agent, for example sodium carbonate. In someimplementations, the pH modulator can also act as a corrosion inhibitor,for example, sodium carbonate. In some implementations, the pH modulatorcan act as a catalyst, for example sodium bicarbonate and sodiumtripolyphosphate.

In some embodiments, it is desirable for the present invention toinitially yield an intense color, such as a color that is intense enoughto be visible on a dark surface such as dark stained wood, navy bluefurniture, etc., and then completely fade away. In some implementations,certain optional additives can be used to improve color intensity andlengthen the color-fading reaction time, including foaming andfoam-boosting agents, pearlizers, opacifying agents, stabilizers,vitamins, and antioxidants. By “completely fade away”, it is intendedthat no visible color residue remains on the surface after a period oftime, which may range from seconds to minutes, for example from 1 to 30seconds to 1 to 60 minutes. This can be quantified in any number ofways, for example by defining a color residue or “streak” as anon-fading color residue pattern visible to the human eye that is of acertain size, for example larger than 1 square inch, and that isremaining on the surface after a period of time following application ofthe indicator composition and disinfectant.

The problem of color residue is particularly apparent on certainsurfaces, especially more porous surfaces as compared to non-poroussurfaces (e.g., wood compared to stainless steel) and surfaces having atexture that is not smooth, for example a texture that is bumpy or evensticky, as compared to smooth surfaces. For example, it is easier toachieve more consistent color-fading reaction times on smooth, hard,non-porous surfaces, such as stainless steel, than on a porous orsemi-porous, bumpy, sticky material such as rubber. This is because, forexample, the pores of the material may absorb the composition and/or asurface that is not smooth may cause uneven distribution of thecomposition and/or its components, such as catalysts and thickeners,altering the fading reaction and leading to incomplete fading of thecolorant. In addition, not all surfaces share the same geometry, shape,or continuity, wherein edges of surfaces, cracks or valleys, holes, andthe like may make uniform application of the indicator compositionsdifficult, resulting in failure of the colorant to completely fade.

In some implementations, where we define a “streak” to mean a non-fadingcolor residue pattern larger than 1 square inch, a reference aqueoussolution of 1% w/v FD&C Blue 1, leaves about 1-5 streaks on a textured,sticky rubber surface. The present inventors have found that includingone or more optional additives in an indicator composition comprisingthe same amount of FD&C Blue 1, or similar colorant such as Acid Blue 1,substantially reduces the color residue, for example the indicatorcomposition leaves only 0-3 or 0-2 or fewer streaks on the same surface,as compared to the reference solution. Thus, in some implementations itis desirable to include one or more optional additives in an indicatorcomposition described here, the one or more optional additives selectedfrom a humectant, an occlusive, a wax, a butter, an oil, aco-surfactant, a filler, a texturizer, an organic acid, an emollient, afoaming and foam-boosting agent, a pearlizer, an opacifying agent, avitamin, an antioxidant, an anti-foaming agent, an emulsifying agent, aco-emulsifier, an emulsion stabilizer, a chelating agent, an anticakingagent, a moisture-absorbing agent, a silicone, a silicone conditioner,an antimicrobial agent and preservative, a stabilizer, a stabilizingsalt, a corrosion inhibitor, a fragrance, an alkyl amine, anoleochemical, a polymer, a copolymer, and combinations or mixturesthereof. For example, an aqueous solution of FD&C Blue 1 and glycerinleaves about 0-3 streaks. The number of streaks is further reduced bythe addition of a wax, decyl glucoside and sodium lauroyl lactylate,kaolin, malic acid, glycol stearate, and PEG-8 dimethicone, to about 0-2streaks. Similarly, an aqueous solution of FD&C Blue 1, glycerin, decylglucoside, and sodium lauroyl lactylate leaves about 0-2 streaks.

In some implementations, humectants, occlusives, waxes, butters, oils,co-surfactants, fillers, texturizers, organic acids, emollients, alkylamines, oleochemicals, polymers, and copolymers can aid in the reductionof colored residue or improved uniformity in color fading reaction time.For example, humectants, such as glycerin, are able to attract moisturefrom the atmosphere, keeping a surface treated by the present inventionin medium for longer, thereby providing a longer-lasting medium in whichthe color-fading reaction can go to completion. Occlusives, such aspetrolatum, waxes, such as castor wax, butters, such as shea butter,oils, such as Prunus armeniaca kernel oil, all work similarly byproviding a thin protective layer over the medium, slowing theevaporation rate and allowing the medium to remain on the surface forlonger. Surfactants such as SDS have been empirically observed todecrease color residue on porous and textured surfaces, makingco-surfactants, such as decyl glucoside and sodium lauroyl lactylate,advantageous given their ability to keep surfactants stable in themedium. In some instances, the color does not uniformly fade on asurface due to the presence of textures or cracks, crevices, and/orwrinkles in the surface that cause pooling and create nonuniform layersof the medium. Fillers, such as arrowroot starch, and texturizers, suchas kaolin, can modify the surface tension to prevent the medium frompooling. Organic acids, such as malic acid, may be used for the purposeof not changing the pH of the solution, but rather to prime the surfaceby smoothing surfaces. Emollients, such as glycol stearate and PEG-8dimethicone, form a film barrier similar to occlusives and can also actas fillers and texturizers to smooth rough surfaces. Alkyl amines, suchas triethanolamine, oleochemical, such as oleamide DEA and cocamide MEA,polymers, such as polyacrylate, and copolymers, such asacylates/octylacrylamide copolymer, all chemically react with anoxidizer, such as a hypochlorite disinfectant, to create a moreoxidative species to speed up the color-fading reaction and preventcolor residue. On a textured, sticky rubber surface, an indicatorcomposition comprising FD&C Blue 1 and glycerin may leave about 0-3streaks; FD&C Blue 1, glycerin, wax, SDS, decyl glucoside, sodiumlauroyl lactylate, kaolin, malic acid, glycol stearate, and PEG-8dimethicone may leave about 0-2 streaks; FD&C Blue 1, glycerin, decylglucoside, and sodium lauroyl lactylate may leave about 0-2 streaks;FD&C Blue 1, cetearyl alcohol, PEG-8 dimethicone, and glycerin may leaveabout 0-2 streaks; FD&C Blue 1, tartaric acid, propylene glycol, andglyceryl mono oleate may leave about 0-2 streaks; FD&C Blue 1,triethanolamine, and cocamide MEA may leave about 0-2 streaks.

The optional additives that improve color-fading may increase the rateof color-fading or reduce the color intensity of an indicatorcomposition described here. In some implementations, foaming andfoam-boosting agents, pearlizer, opacifying agents, stabilizers,vitamins, and antioxidants, can be used to improve color intensity andlengthen the color-fading reaction time. Foaming and foam-boostingagents, such as castile soap and ammonium lauryl sulfate, empiricallymakes the color more visible. Pearlizers, such as bismuth oxychlorideand glycol distearate, allow the color to be more reflective onsurfaces, thus enhancing its visibility. Opacifying agents, such astitanium dioxide, titanium dioxide nanopowder, and mica, provides a baseor body to the color making it look less translucent. Vitamins, such asvitamin E, and antioxidants, such as butylated hydroxytoluene, can reactwith the catalyst or the oxidizer and slow the rate of the reaction,allowing the color-fading time to take longer. For example, an indicatorcomposition comprising FD&C Blue 1 may fade in about 2-4 minutes, whilean indicator composition comprising FD&C Blue 1, ammonium laurylsulfate, glycol distearate, vitamin E, and titanium dioxide nanopowderappears visibly darker and may fade in color completely in about 4-12minutes. In some implementations, an anti-foaming agent, such asglycerin, propylene glycol, and cyclo-dimethicone, can be used to reduceexcessive effervescence or foaminess of the foaming or foam-boostingagent.

Some of the optional additives, such as opacifying agents like titaniumdioxide and mica, may not be readily soluble in a water based medium,resulting in uneven or inconsistent application on surfaces or cloggingof the device 400. Accordingly, in some implementations, emulsifyingagents, co-emulsifiers, emulsion stabilizers, chelating agents, andanticaking agents may be included in the indicator composition.Emulsifying or dispersing agents, such as PEG-8 dimethicone, dimethiconephosphates, polysorbates, polyacrylates and polyphosphates may be usedto create emulsions and microemulsions that disperse and suspend desirednon-polar or insoluble additives. Co-emulsifiers, such as cetearylalcohol, boric acid, and cetyl alcohol, may improve the viscosity andstability of the resultant emulsion. Emulsion stabilizers, such aspolyelectrolytes, similarly maintain the stability of the emulsion andprevent polar and non-polar additives from reforming separate layers inthe medium. Chelating agents, such as EDTA, may bind with metalcompounds to form a stable solution that does not separate. Anticakingagents, such as calcium stearate and magnesium stearate, may preventlumps from forming in solution, such as when a non-polar additive isadded to a polar solvent, preventing dissolution and maintaininghomogeneity of the solution. For example, an indicator compositioncomprising FD&C Blue 1 and titanium dioxide may clog the device 400 inabout 10-50% of uses and lead to settling of titanium dioxide after 3hours, while an indicator composition comprising FD&C Blue 1, titaniumdioxide, PEG-8 dimethicone, sodium polyacrylate, cetyl alcohol,polyelectrolytes, EDTA, and magnesium stearate is less likely to clogthe device 400 and prevent any settling of titanium dioxide.

In some embodiments, the addition of an optional additive to theindicator composition, such as wax or glycerin, may leave behind an oilyresidue on the surface which is undesirable to the user.Moisture-absorbing agents, such as PEG-400 stearate and corn starch, maybe used to bind to oily or waxy compounds. For example, an indicatorcomposition comprising FD&C Blue 1 and wax may leave behind a visibleoily film, while an indicator composition comprising FD&C Blue 1, wax,and corn starch may not leave behind any visible residue.

In some implementations, silicones, such as PEG/PPG-20/23 dimethicone,PEG/PPG-23/6 dimethicone, PEG/PPG 18-18 dimethicone, and PEG/PPG 15-15dimethicone, may be used as an emulsifying agent, anticaking agent,emulsion stabilizer, or surfactant given its properties as a filmformer, slip modifier, and surface modifier. Silicone conditioners, suchas dimethicone satin, help silicones remain stable and solubilized inthe medium.

In some implementations, antimicrobial agents and preservatives, such asacrylic acid copolymer, phenoxyethanol, and iodopropynyl butacarbamate,are advantageous when the medium is water-based, being conducive togrowth of unwanted organisms that may interfere in the color-changingreaction or are otherwise undesirable for use in healthcare settings.For example, an indicator composition comprising FD&C Blue 1 and vitaminE may have a usable shelf life of about 6 months, while an indicatorcomposition comprising FD&C Blue 1, vitamin E, phenoxyethanol, andiodopropynyl butacarbamate may have a usable shelf life of about 12months or longer.

In some implementations, stabilizers, such astris(2,4-di-tert-butylphenyl)phosphite and hindered amine lightstabilizers (HALS), and stabilizing salts, such as trisodium citrate,monosodium phosphate, and disodium phosphate, are advantageous topreserve the stability of fragile additives, such as structurallydelicate colorants (e.g., crystal violet lactone), and protectcomponents of the product from aging and weathering. For example, anindicator composition comprising crystal violet lactone in an alcoholbased solvent may only remain colored for about less than 1 minute,while an indicator composition comprising crystal violet lactone,tris(2,4-di-tert-butylphenyl)phosphite, and trisodium citrate in analcohol based solvent may remain colored for about 10 minutes.

In some implementations, a corrosion inhibitor, such as sodium carbonateor FD&C Blue 1, may be desirable for reducing corrosion on surfaces suchas finished wood, to prevent the surface from losing texture or coatingand subsequently turning from non-porous to semi-porous. For example, asodium hypochlorite wipe may cause severe corrosion at a rate of greaterthan 5 mpy over a month on stainless steel, while a sodium hypochloritewipe with FD&C Blue 1 and sodium carbonate may cause negligiblecorrosion at a rate of less than 2 mpy over a month on stainless steel.

In some implementations, a fragrance or perfume, such as Citrus grandisseed extract, may be used to mask the harsh smell of the disinfectant,such as bleach, making the product easier to use.

The examples above are used illustratively and are not limiting. Furtherexamples of each of the optional additives are included below.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional humectants.In some implementations, the humectant is glycerin or glycerol.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional occlusives.In some implementations, the occlusive is selected from petrolatum,lanolin, argan oil, safflower oil, mineral oil, olive oil, jojoba oil,or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional waxes. Insome implementations, the wax is selected from castor wax, bees wax,candelilla wax, carnauba wax, lanolin alcohol, lauryl laurate, PEG-8beeswax, polyhydroxystearic acid, sunflower wax, ozokerite wax,microcrystalline wax, tribehenin, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional butters. Insome implementations, the butter is selected from avocado butter, cocoabutter, green tea butter, shea butter, mango butter, or combinationsthereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional oils. Insome implementations, the oil is selected from Prunus armeniaca kerneloil, Prunus amygdalus dulcis oil, Borago officinalis oil, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionalco-surfactants, whose purpose is to complement surfactants in any waynecessary (i.e., help dissolve a surfactant). In some implementations,the co-surfactant is selected from glyceryl mono oleate, decylglucoside, glyceryl monostearate, or combinations thereof. In someimplementations, the co-surfactant is 0.005%-50% undefined blend ofdecyl glucoside and sodium lauroyl lactylate.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional fillers. Insome implementations, the filler is selected from mica powder, tapiocastarch polymethylsilsesquioxane, LiPeptide, isohexadecane,ethylene/propylene/styrene copolymer, butylene/ethylene/styrenecopolymer, sodium hyaluronate, xanthan gum, phenoxyethanol,tripeptide-1, magnesium hydroxide, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional texturizers.In some implementations, the texturizer is selected from arrowrootstarch, bentonite, bismuth oxychloride, charcoal powder, colloidaloatmeal, dead sea mud, hydroxypropyl starch phosphate, kaolin, Oryzasativa, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional organicacids. In some implementations, the organic acid does not affect ormaintain the pH of the solution. In some implementations, the organicacid is selected from acids with carboxylic or sulfonic groups, such asmalic acid, tartaric acid, lactic acid, and butyric acid, andcombinations of any of the foregoing.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional emollients.In some implementations, the emollient is selected fromcyclopentasiloxane, dimethicone, dimethicone coated titanium dioxide,isododecane, phenyltrimethicone, alcohol benzoates, isononylisononanoate, PEG-8 dimethicone, octyldodecanol, PEG-8 dimethiconemeadowfoamate, cetyl palmitate, naturally-derived oils (e.g. borage seedoil, Prunus armeniaca kernel oil, grape seed oil, apricot kernel oil,avocado oil, argan oil, apple seed oil, squalene oil), or combinationsthereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional foaming orfoam-boosting agents. In some implementations, the foaming agents isselected from castile soap, ammonium lauryl sulfate, cocamidopropylhydroxysultaine, glycerin, cocamidopropylamine oxide, cocamidopropylbetaine, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional pearlizers.In some implementations, the pearlizer is selected from glycoldistearate, bismuth oxychloride, and combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional opacifyingagents. In some implementations, the opacifying agent is selected fromtransition metal oxides, both in regular form and in nanopowder form(e.g. TiO2 (titanium dioxide), ZnO (zinc oxide)), glyceryl monostearate,dimethicone coated titanium dioxide, glycol distearate, micas (e.g.sericite mica, white sericite mica, silk mica, pearl white mica), orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional vitamins. Insome implementations, the vitamin is selected from retinol,phytonadione, menaquinone, ascorbic acid, ascorbate salts, thiamin,riboflavin, niacin, niacinamide pyridoxine, cyanocobalamin, folic acid,biotin, pantothenic acid, ergocalciferol, cholecalciferol, tocopherols,tocotrienols, phylloquinone, hydroxocobalamin, adenosylcobalamin,methylcobalamin, carotenoids, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionalantioxidants. In some implementations, the antioxidant is selected frombutylated hydroxytoluene, beta carotene, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional anti-foamingagents. In some implementations, the anti-foaming agent is glycerin,propylene glycol, cyclomethicone, dimethicone, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional emulsifyingagents. In some implementations, the emulsifying agent is selected fromsodium phosphate (e.g. monosodium phosphate, sodium tripolyphosphate),dimethicone copolyols (e.g. PEG/PPG-18/18 dimethicone), stearic acid,polyglyceryl-4 isostearate, triethanolamine, ceteareth-25, cetearylalcohol, sodium lauroyl lactylate, alcohol (e.g. propanol, ethanol,1-decanol), denatured alcohol, ceteareth-20, PEG-100 stearate, PEG-400stearate, isopropanolamides of coconut acid (cocamide MIPA), sorbitanstearate, non-foaming emulsifying wax, sorbitan salts (e.g. sorbitanolivate), cetearyl salts (e.g. cetearyl olivate), 2-phenoxyethanol,polyhydroxystearic acid, polyglyceryl-6 polyricinoleate, or combinationsthereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionalco-emulsifiers. In some implementations, the co-emulsifier is boricacid, cetyl alcohol, cetearyl alcohol, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional emulsionstabilizers. In some implementations, the emulsion stabilizer isselected from dimethicone copolyols (e.g. PEG/PPG-20/23 dimethicone,PEG/PPG-23/6 dimethicone), chloride salts (e.g. sodium chloride,potassium chloride), disteardimonium hectorite, polyethylene, fumedsilica, magnesium sulfate, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional chelatingagents. In some implementations, the chelating agent is selected fromEDTA salts (e.g., disodium EDTA), phosphonates, citric acid, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional anticakingagents. In some implementations, the anticaking agent is selected fromdimethicone copolyols (e.g., PEG/PPG-15/15 dimethicone), corn starch, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionalmoisture-absorbing agents. In some implementations, themoisture-absorbing agent is selected from corn starch, talc, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional silicones.In some implementations, the silicone is selected from amodimethicone, adimethicone, or a combination thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional siliconeconditioners. In some implementations, the silicone conditioner isdimethicone satin.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionalantimicrobial agents or preservatives. In some implementations, theantimicrobial agent or preservative is selected from 2-phenoxyethanol,benzyl alcohol, caprylyl glycol, ethylhexyl glycerin, hexanediol, EDTAsalts (e.g., disodium EDTA), parabens (e.g., methylparaben,propylparaben), iodopropynyl butacarbamate, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional stabilizers.In some implementations, the stabilizer is selected from EDTA, sodiumgluconate, butylated hydroxytoluene, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional stabilizingsalts. In some implementations, the stabilizing salt is selected fromsodium sulfate, magnesium chloride, sodium chloride, potassium chloride,or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain an optional corrosion inhibitor,or a mixture of corrosion inhibitors. In some implementations, thecorrosion inhibitor is selected from sodium carbonate, calcium chloride,zinc chloride, sodium polyacrylate, silicate, benzimidazole,benzotriazole, calcium succinate, calcium sulfate, ascorbic acid,glucaric acid, gluconic acid, zinc sulfate, cerium chloride, sodiumchromate, nitrates, phosphates, magnesium salts, nickel salts, calciumsalts, succinic acid, tryptamine, and mercaptobenzothiazole orcombinations thereof. In some implementations, the colorant itself mayact as a corrosion inhibitor, for example the dye, FD&C Blue #1, can beused as the anti-corrosion or corrosion inhibitor. In addition, pHmodifiers such as acids and bases, can be added as anti-corrosion agentsor corrosion inhibitors.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional perfumes orfragrances. In some implementations, the perfume or fragrance isselected from citric acid, anise oil, pinene, bay leaf oil, benzoicacid, acetic acid, camphor oil, florex, geranium oil, grapefruit oil,juniper lactone, lemon oil, myristic oil, orange oil terpenes, Citrusgrandis seed extract, sandalwood, and vanillin, or combinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional alkylamines. In some implementations, the alkyl amine is selected fromtriethanolamine, diethanolamine, triethylamine, methylamine, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optionaloleochemicals. In some implementations, the oleochemical is selectedfrom cocamide DEA, oleamide DEA, lauramide DEA, linoleamide DEA, orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional polymers. Insome implementations, the polymer is selected from polyacrylic acid,polyvinylamides, polyacrylates, polymethacrylates, and cross-linkedpolymers (e.g., ethers of pentaerythritol, divinylbenzene), orcombinations thereof.

In some implementations, a single or multi-component indicatorcomposition described here may contain one or more optional copolymers.In some implementations, the copolymer is selected fromacylates/octylacrylamide copolymer, acrylates/steareth-20 methacrylatecopolymer, or combinations thereof.

In embodiments where disinfectants are included in the single ormulti-component indicator composition, examples of disinfectants includesodium hypochlorite, calcium hypochlorite, sodium dichloroisocyanurate,didecyldimethylammonium chloride, chlorhexidine gluconate, a phenol, analdehyde, a terpene, hydrogen peroxide, chlorine dioxide, a peroxy andperoxo acid such as peracetic acid, a quaternary ammonium compound, aninorganic compound such as metals and acids, and alcohols such asethanol and isopropyl alcohol. These disinfectant compositions may becombined with or separated from other components as described here in asingle or multi-chamber article of manufacture. Disinfectantcompositions may also come from a disinfectant article of manufacture.In embodiments, disinfectant compositions contained within single ormulti-chamber articles of manufacture may be added to the same ordifferent disinfectant compositions contained on a disinfectant articleof manufacture. In some embodiments, adding the same disinfectantcomposition onto a disinfectant article of manufacture is advantageousto provide a different indicator composition to disinfectant compositionratio, as described further below.

The present disclosure includes indicator compositions diluted indisinfectant compositions. The disinfectant composition may come from adisinfectant article of manufacture or may be contained in a single ormulti-chamber article of manufacture. The ratio of indicator compositionto disinfectant composition ranges from 0.0001:1 to 10:1, including, butnot limited to, 0.001:1, 0.01:1, 0.1:1, 0.5:1, 1:1, 2:1, 5:1, and 10:1.

In some implementations, where the indicator composition is amulti-component composition, the colorant is preferably contained in aseparate component from the catalyst, for example in a separatecompartment or reservoir of an article of manufacture comprising themulti-component composition. It is generally undesirable to includecolorants in the same component with either reducing agents, oxidizingagents, a base, or a strong metal catalyst. However, in someimplementations, the colorant may be contained in the same componentwith a weak metal salt, such as a Cu′ salt. In implementations where thecatalyst comprises an iron salt, the component comprising the iron saltpreferably further comprises a pH modulator, such as an acid, sufficientto maintain the iron salt in an acidic aqueous environment. Inimplementations where the catalyst of a multi-component compositioncomprises a reducing agent and a surfactant, preferably the reducingagent and surfactant are contained in the same component of thecomposition, for example in the same compartment or reservoir of anarticle of manufacture comprising the multi-component composition. Inimplementations where the catalyst comprises both a reducing agent andan oxidizing agent, the oxidizing and reducing agents are preferablycontained in two separate components, for example in two separatecompartments or reservoirs of an article of manufacture comprising themulti-component composition.

In some implementations, and as described above, the disclosure providesa device for use with the multi-component indicator compositionsdescribed here. The device may comprise a reservoir having at least twoseparate compartments, optionally having 2, 3, or 4 separatecompartments, further optionally having more than 4 separatecompartments, at least one applicator element comprising an automatic ormanual mechanism, for example a spray mechanism, and a pump element, forexample one that pumps an amount of the contents of each of the separatecompartments towards either a further compartment in which they aremixed, or to the applicator element where they are mixed simultaneouslywith dispensing from the device. In some implementations, the device isactuated when a user pushes on an actuator such as a lever, button, orother mechanism, which mechanism may be manual or automatic.

In some implementations, the disclosure provides an article ofmanufacture comprising a multi-component indicator composition describedhere, in which the article of manufacture comprises separatecompartments for each component of the multi-component indicatorcomposition and is optionally adapted to work with, or within, a deviceas described here.

Indicator compositions adapted for use with various disinfectantcompositions, including hypochlorite and troclosene based disinfectants,quaternary ammonium and alcohol based disinfectants, hydrogen peroxidebased disinfectants, and peracetic acid based disinfectants, aredescribed in more detail in the following sections.

Indicator Compositions for Hypochlorite and Troclosene BasedDisinfectants

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with hypochloriteand troclosene based disinfectant compositions. For example, theindicator composition may consist of two, three, four or more separatecomponents which are combined at the point of use, for example using adevice described herein. In some implementations, the multi-componentcomposition comprises at least two separate components, the firstcomponent comprising a disinfectant composition in the form of anaqueous solution of sodium dichloroisocyanurate (“NaDCC” also referredto as “troclosene”) or a disinfectant composition in the form of anaqueous solution of a metal salt of hypochlorous acid, for examplesodium or calcium hypochlorite (NaOCl or Ca(OCl)₂), optionallycomprising a pH modulator sufficient to maintain an alkaline pH of about10-11; and the second component comprising at least one colorant and anacidic agent or acidifying agent as a pH modulator sufficient tomaintain the pH of the second component at a pH of about 4-5, optionallya pH of between 4 and 7; and further optionally comprising one or moreadditives selected from a surfactant or mixture of surfactants, arheology modifier, a stabilizer or corrosion inhibitor, a solubilizingagent, an antimicrobial agent, an opacifying agent, and a perfume orfragrance, as additives in either the first or second components, orboth, or optionally as a third aqueous component comprising the one ormore additives. In some implementations, the one or more additives maybe selected from one or more of a surfactant, rheology modifier orthickener, a humectant, an occlusive, a wax, a butter, an oil, aco-surfactant, a filler, a texturizer, an organic acid, an emollient, afoaming and foam-boosting agent, a pearlizer, an opacifying agent, avitamin, an antioxidant, an anti-foaming agent, an emulsifying agent, aco-emulsifier, an emulsion stabilizer, a chelating agent, an anticakingagent, a moisture-absorbing agent, a silicone, a silicone conditioner,an antimicrobial agent and preservative, a stabilizer, a stabilizingsalt, a corrosion inhibitor, a fragrance, an alkyl amine, anoleochemical, polymers, copolymers, and mixtures of two or more of anyof the foregoing, as additives in either the first or second components,or both, or optionally as a third aqueous component comprising the oneor more additives.

In one implementation, a device for use with the multi-componentindicator compositions described here comprises two separatecompartments, the first compartment comprising a disinfectantcomposition in the form of an aqueous solution of sodiumdichloroisocyanurate (“NaDCC” also referred to as “troclosene”) or adisinfectant composition in the form of an aqueous solution of a metalsalt of hypochlorous acid, for example sodium or calcium hypochlorite(NaOCl or Ca(OCl)₂), optionally comprising a pH modulator sufficient tomaintain an alkaline pH of about 10-11; and the second compartmentcomprising at least one colorant and an acidic agent as a pH modulatorsufficient to maintain the pH of the component in the second compartmentat a pH of about 4-5; and further optionally comprising one or more of asurfactant or mixture of surfactants, a rheology modifier, a bufferingagent, a stabilizer or a corrosion inhibitor, a solubilizing agent, anantimicrobial agent, an opacifying agent, and a perfume or fragrance, ineither the first or second compartments. In some implementations theacidic component may be formed from citric acid, benzoic acid, aceticacid, and mixtures thereof. In some implementations, the composition mayoptionally comprise one or more of a surfactant, a rheology modifier, ahumectant, an occlusive, a wax, a butter, an oil, a co-surfactant, afiller, a texturizer, an organic acid, an emollient, a foaming andfoam-boosting agent, a pearlizer, an opacifying agent, a vitamin, anantioxidant, an anti-foaming agent, an emulsifying agent, aco-emulsifier, an emulsion stabilizer, a chelating agent, an anticakingagent, a moisture-absorbing agent, a silicone, a silicone conditioner,an antimicrobial agent and preservative, a stabilizer, a stabilizingsalt, a corrosion inhibitor, a fragrance, an alkyl amine, anoleochemical, polymers, copolymers or a mixture of two or more of any ofthe foregoing, in either the first or second compartments.

Preferably, the components of a multi-component composition are providedseparately, e.g., in separate chambers of a cartridge as describedabove, specifically when their combination before use would otherwiseresult in degradation of one or more of the components or thecomposition itself, such as by unfavorable precipitation of one or moreof the components or oxidation of one or more of the components. Forexample, where the point of use composition comprises a disinfectantthat is a strong oxidizer, such as sodium hypochlorite or hydrogenperoxide, a colorant such as Acid Blue 1, and a combination of cationicand anionic surfactants such as sodium mono oleate andhexadecyltrimethylammonium bromide (HTAB), it is advantageous to keepthe colorant separate from the disinfectant, since upon theircombination the colorant will fade. In addition, the combination ofcationic and anionic surfactants is likely to result in undesirableprecipitation of the surfactants over time, making it advantageous tokeep them separate until they are combined for use. Certain thickenersare also advantageously stored separately, such as PEG-400 and glycerylstearate, which may precipitate when combined. To illustrate thisspecific example, the multi-chambered cartridge would contain sodiumhypochlorite in one chamber, Acid Blue 1 and sodium mono oleate in asecond separate chamber, and HTAB in a third separate chamber.

In some implementations, the disinfectant composition is selected fromsodium hypochlorite, calcium hypochlorite, and troclosene sodium, inamounts ranging from 0.05%-20%, preferably 0.1-5%, or 0.4-2%.

In some implementations the acidic agent or the acidifying agent maycomprise citric acid, benzoic acid, acetic acid, such as glacial aceticacid, 5% acetic acid, and mixtures thereof. Other suitable acids can beused including for example hydrochloric, sulfuric, ascorbic, nitric,hydrobromic, perchloric, chloric, hydrofluoric, formic, nitrous,phosphoric, oxalic, vinegar, peracetic, boric, carbonic, ethanoic, andtartaric acids. In some implementations, the indicator composition inthe dispensing cartridge 413 comprises an additive in the form of anacidic agent or acidifying agent as described herein.

In some implementations, the pH modulator sufficient to maintain analkaline pH of the disinfectant composition comprises an alkalinebuilder, for example one or more of sodium hydroxide (NaOH), calciumhydroxide (Ca(OH)₂), potassium hydroxide (KOH), lithium hydroxide(LiOH), and mixtures thereof.

In some implementations, the at least one colorant of the indicatorcomposition is a water-soluble oxidizable dye, preferably selected froman azo dye, a triarylmethane dye, a cationic dye, an anionic dye, athiazine dye, and a leuco dye. In some implementations, the colorant isselected from FD&C Blue 1, Acid Blue 1, Direct Blue 1, Acid Green 50,Acid Green 25, Patent Blue V, FD&C Yellow 6, Fast Green FCF, IndigoCarmine, Acid Blue 80, Remazol Brilliant Blue R, Coomassie BrilliantBlue, Crystal Violet Lactone, Thymolphthalein, Bromothymol Blue,Methylene Blue, FD&C Red 2, and mixtures thereof. In someimplementations, the colorant is FD&C Blue 1, Acid Blue 1, or Acid Green50. In some implementations, the colorant is FD&C Blue 1. Generally, theamount of the colorant may range from about 0.01%-25% w/v, based on thevolume of the disinfectant solution to be colored, preferably about0.05-2%, or about 0.1%-1%, or about 0.1%-0.5%, depending on theparticular colorant and strength of the disinfectant composition, aswell as the desired strength of the initial color and desired fade timeof the colored disinfectant following its application to a surface. Forexample, in some implementations the colorant is 0.1%-0.5% FD&C Blue 1,or 0.1%-1% FD&C Blue 1, Acid Blue 1, or Acid Green 50.

In some implementations, the one or more optional surfactants may beselected from sodium dodecyl sulfate (SDS), sodium xylene sulfonate(SXS), sodium laureth sulfate (SLES), sodium myreth sulfate (SMS),sodium cholate, an acetylenic diol (e.g., Surfynol™ 104S), glycerylmonostearate, glyceryl monooleate, sodium stearate, sodiumcocoamphoacetate, lauryl glucoside, sodium cocoyl glutamate, sodiumlauryl glucose carboxylate, decyl glucoside, sodium lauroyl lactylate,ceteareth-20, HTAB, benzene, 1,1′-oxybis-tetrapropylene derivatives,sulfonated, sodium salts (e.g., DOWFAX™ 2A1 blend), and sodium toluenesulfonate (STS), and mixtures thereof; the optional stabilizer orcorrosion inhibitor may be selected from sodium chloride, sodiumchlorate, sodium polyacrylate, sodium carbonate, lauramine oxide, andsodium orthosilicate; and the perfume or fragrance may be selected fromcitric acid, anise oil, pinene, bay leaf oil, benzoic acid, acetic acid,camphor oil, florex, geranium oil, grapefruit oil, juniper lactone,lemon oil, myristic oil, orange oil terpenes, Citrus grandis seedextract, sandalwood, and vanillin, or combinations thereof.

In some implementations, the one or more optional rheology modifiers isselected from sodium alginate, glycerin, glycerol, guar gum, locustbean, dextran, cellulose, carrageenan (lambda, iota, kappa), sodiumcarbonate, fumed silica, alkali swellable emulsions (ASE),hydrophobically modified alkali swellable emulsions (HASE),hydrophobically modified polyurethanes (HEUR), hydrophobically modifiedpolyethers (HMPE), inorganic rheology modifiers (attapulgites), castoroil based thixotropes, sodium polyacrylate, ethylene glycol, propyleneglycol, butylene glycol, propanediol, lecithins, orbeth-230 tetraoleate,PEG-120 methyl glucose dioleate, methyl gluceth-10, corn starch,triethanolamine, and mixtures thereof. In embodiments, the rheologymodifier is glycerin or lambda carrageenan. The rheology modifier maygenerally be present in an amount of from about 0.05-5 wt %, or from0.2-0.4 wt % e.g., for lambda carrageenan, or from 1-5% for glycerin.

In some implementations, the one or more optional rheology modifiers isselected from a polymer, a copolymer, and mixtures thereof. In someimplementations, the polymer or copolymer is selected from one or moreof a polyvinyl carboxy polymer crosslinked with ethers ofpentaerythritol (e.g., Carbomer™ 940), an octylacrylamide/acrylatescopolymer, a poly(acrylic acid) copolymer including copolymers ofdiffering molecular weights comprised of monomers of octylacrylamide,acrylic acid, methyl acrylic acid, and other acrylates. In someimplementations, the rheology modifiers have the additional benefit ofacting to fade the dye more quickly, thus allowing fade time to becontrolled (e.g., acrylates/octylacrylamide copolymer), the additionalbenefit of acting as a humectant (e.g., glycerin), the additionalbenefit of acting as a surfactant (e.g., glyceryl mono oleate), theadditional benefit of acting as an oil (e.g. cocamide), the additionalbenefit of acting as a pH adjuster (e.g., Carbomer™ 940), and theadditional benefit of acting as an emulsifier (e.g., glyceryl stearate).

In some implementations, the one or more optional rheology modifiers isselected from glycerin, glyceryl stearate, glyceryl oleate, chloridesalts (e.g., magnesium chloride, sodium chloride), cetearyl alcohol,carbomers (e.g., Carbomer™ 940), and mixtures thereof.

In some implementations, the one or more optional humectants is glycerinor glycerol.

In some implementations, the one or more optional occlusives is selectedfrom petrolatum, lanolin, olive oil, jojoba oil, or combinationsthereof.

In some implementations, the one or more optional waxes is selected fromcastor wax, bees wax, candelilla wax, carnauba wax, lanolin alcohol,lauryl laurate, PEG-8 beeswax, polyhydroxystearic acid, sunflower wax,ozokerite wax, microcrystalline wax, tribehenin, or combinationsthereof.

In some implementations, the one or more optional butters is selectedfrom avocado butter, cocoa butter, green tea butter, shea butter, mangobutter, or combinations thereof.

In some implementations, the one or more optional oils is selected fromPrunus armeniaca kernel oil, Prunus amygdalus dulcis oil, Boragoofficinalis oil, or combinations thereof.

In some implementations, the one or more optional co-surfactants isselected from glyceryl mono oleate, decyl glucoside, glycerylmonostearate, or combinations thereof.

In some implementations, the one or more optional fillers is selectedfrom mica powder, tapioca starch polymethylsilsesquioxane, LiPeptide,isohexadecane, ethylene/propylene/styrene copolymer,butylene/ethylene/styrene copolymer, sodium hyaluronate, xanthan gum,phenoxyethanol, tripeptide-1, magnesium hydroxide, or combinationsthereof.

In some implementations, the one or more optional texturizers isselected from arrowroot starch, bentonite, bismuth oxychloride, charcoalpowder, colloidal oatmeal, dead sea mud, hydroxypropyl starch phosphate,kaolin, Oryza sativa, or combinations thereof.

In some implementations, the one or more optional organic acids isselected from acids with carboxylic or sulfonic groups, such as malicacid and butyric acid.

In some implementations, the one or more optional emollients is selectedfrom cyclopentasiloxane, dimethicone, dimethicone coated titaniumdioxide, isododecane, phenyltrimethicone, alcohol benzoates, isononylisononanoate, PEG-8 dimethicone, octyldodecanol, PEG-8 dimethiconemeadowfoamate, cetyl palmitate, naturally-derived oils (e.g. borage seedoil, Prunus armeniaca kernel oil, grape seed oil, apricot kernel oil,avocado oil, argan oil, apple seed oil, squalene oil), or combinationsthereof.

In some implementations, the one or more optional foaming agents isselected from castile soap, ammonium lauryl sulfate, cocamidopropylhydroxysultaine, glycerin, cocamidopropylamine oxide, cocamidopropylbetaine, or combinations thereof.

In some implementations, the one or more optional pearlizer is glycoldistearate.

In some implementations, the one or more optional opacifying agents isselected from transition metal oxides, both in regular form and innanopowder form e.g., titanium dioxide (TiO₂), zinc oxide (ZnO),glyceryl monostearate, dimethicone coated titanium dioxide, glycoldistearate, micas (e.g., sericite mica, white sericite mica, silk mica,pearl white mica), or combinations thereof.

In some implementations, the one or more optional vitamins is selectedfrom retinol, phytonadione, menaquinone, ascorbic acid, ascorbate salts,thiamin, riboflavin, niacin, niacinamide pyridoxine, cyanocobalamin,folic acid, biotin, pantothenic acid, ergocalciferol, cholecalciferol,tocopherols, tocotrienols, phylloquinone, hydroxocobalamin,adenosylcobalamin, methylcobalamin, carotenoids, or combinationsthereof.

In some implementations, the one or more optional antioxidants isselected from butylated hydroxytoluene, beta carotene, or combinationsthereof.

In some implementations, the one or more optional anti-foaming agents isglycerin, propylene glycol, cyclomethicone, dimethicone, or combinationsthereof.

In some implementations, the one or more optional emulsifying agents isselected from sodium phosphate (e.g. monosodium phosphate, sodiumtripolyphosphate), dimethicone copolyols (e.g. PEG/PPG-18/18dimethicone), stearic acid, polyglyceryl-4 isostearate, triethanolamine,ceteareth-25, cetearyl alcohol, sodium lauroyl lactylate, alcohol (e.g.propanol, ethanol, 1-decanol), denatured alcohol, ceteareth-20, PEG-100stearate, PEG-400 stearate, isopropanolamides of coconut acid (cocamideMIPA), sorbitan stearate, non-foaming emulsifying wax, sorbitan salts(e.g. sorbitan olivate), cetearyl salts (e.g. cetearyl olivate),2-phenoxyethanol, polyhydroxystearic acid, polyglyceryl-6polyricinoleate, or combinations thereof.

In some implementations, the one or more optional co-emulsifiers isboric acid, cetyl alcohol, cetearyl alcohol, or combinations thereof.

In some implementations, the one or more optional emulsion stabilizersis selected from dimethicone copolyols (e.g. PEG/PPG-20/23 dimethicone,PEG/PPG-23/6 dimethicone), chloride salts (e.g. sodium chloride,potassium chloride), disteardimonium hectorite, polyethylene, fumedsilica, magnesium sulfate, or combinations thereof.

In some implementations, the one or more optional chelating agents isselected from EDTA salts (e.g., disodium EDTA), phosphonates, citricacid, or combinations thereof.

In some implementations, the one or more optional anticaking agents isselected from dimethicone copolyols (e.g. PEG/PPG-15/15 Dimethicone),corn starch, or combinations thereof.

In some implementations, the one or more optional moisture-absorbingagents is selected from corn starch, talc, or combinations thereof.

In some implementations, the one or more optional silicones is selectedfrom amodimethicone, a dimethicone, or a combination thereof.

In some implementations, the one or more optional silicone conditioneris dimethicone satin.

In some implementations, the one or more optional antimicrobial agentsor preservatives is selected from 2-phenoxyethanol, benzyl alcohol,caprylyl glycol, ethylhexyl glycerin, hexanediol, EDTA salts (e.g.disodium EDTA), parabens (e.g. methylparaben, propylparaben),iodopropynyl butacarbamate, or combinations thereof.

In some implementations, the one or more optional stabilizers isselected from EDTA, sodium gluconate, butylated hydroxytoluene, orcombinations thereof.

In some implementations, the one or more optional stabilizing salts isselected from sodium sulfate, magnesium chloride, sodium chloride,potassium chloride, or combinations thereof.

In some implementations, the one or more optional corrosion inhibitorsis selected from sodium carbonate, calcium chloride, zinc chloride,sodium polyacrylate, silicate, benzimidazole, benzotriazole, calciumsuccinate, calcium sulfate, ascorbic acid, glucaric acid, gluconic acid,zinc sulfate, cerium chloride, sodium chromate, nitrates, phosphates,magnesium salts, nickel salts, calcium salts, succinic acid, tryptamine,and mercaptobenzothiazole or combinations thereof. In someimplementations, the colorant itself may act as a corrosion inhibitor,for example the dye, FD&C Blue #1, can be used as the anti-corrosion orcorrosion inhibitor. In addition, pH modifiers such as acids and bases,can be added as anti-corrosion agents or corrosion inhibitors.

In some implementations, the one or more optional perfumes or fragrancesis selected from citric acid, anise oil, pinene, bay leaf oil, benzoicacid, acetic acid, camphor oil, florex, geranium oil, grapefruit oil,juniper lactone, lemon oil, myristic oil, orange oil terpenes, Citrusgrandis seed extract, sandalwood, and vanillin, or combinations thereof.

In some implementations, the one or more alkyl amines is selected fromtriethanolamine, diethanolamine, triethylamine, methylamine, orcombinations thereof.

In some implementations, the one or more oleochemicals is selected fromcocamide DEA, oleamide DEA, lauramide DEA, linoleamide DEA, orcombinations thereof.

In some implementations, the one or more polymers is selected frompolyacrylic acid, polyvinylamides, polyacrylates, polymethacrylates, andcross-linked polymers (e.g., ethers of pentaerythritol, divinylbenzene),or combinations thereof.

In some implementations, the one or more copolymers is selected fromacylates/octylacrylamide copolymer, acrylates/steareth-20 methacrylatecopolymer, or combinations thereof.

In some implementations, the disclosure provides a two-componentcomposition comprising an indicator composition and an acidifiedhypochlorite based disinfectant composition, optionally furthercomprising a surfactant or rheology modifier, or both, the indicatorcomposition comprising a colorant selected from any of a triarylmethane,azo, or acid dye, for example, indigo carmine, Acid Blue 1, FD&C Blue 1,etc., in amounts ranging from about 0.001-15% w/v, preferably from about0.05-0.50% w/v, or 0.10-0.50% w/v based on the volume of thedisinfectant solution to be colored wherein upon combination of the twocomponents, for example via actuation of a device as described herein,the resulting colored disinfectant composition has a fade time of about30 seconds to 2 minutes, or from about 30 seconds to 10 minutes afterits application to a surface.

In some implementations, the disclosure provides a two-componentcomposition comprising an acidified indicator composition and ahypochlorite based disinfectant composition, optionally furthercomprising a surfactant or rheology modifier, or both, the indicatorcomposition comprising a colorant selected from any of a triarylmethane,azo, or acid dye, for example, indigo carmine, Acid Blue 1, FD&C Blue 1,etc., in amounts ranging from about 0.001-15% w/v, preferably from about0.05-2.0% w/v, or 0.10-1.0% w/v based on the volume of the disinfectantsolution to be colored wherein upon combination of the two components,for example via actuation of a device as described herein, the resultingcolored disinfectant composition has a fade time of about 30 seconds to2 minutes, or from about 30 seconds to 10 minutes after its applicationto a surface.

In some implementations, the indicator composition comprises a colorantselected from any of a triarylmethane, azo, or acid dye, preferablyselected from indigo carmine, Acid Blue 1, or FD&C Blue 1, in amountsranging from about 0.001-15% w/v, preferably from about 0.05-2.0% w/v,or from about 0.10-1.0%, or from about 0.05-0.50% w/v, or from about0.10-0.50% w/v, and a surfactant or rheology modifier, or both. In someimplementations, the indicator composition comprises a colorant selectedfrom any of a triarylmethane, azo, or acid dye, preferably selected fromindigo carmine, Acid Blue 1, or FD&C Blue 1, and the indicatorcomposition further comprises a rheology modifier. In someimplementations the rheology modifier is glycerin. The glycerin may bepresent, for example, at about 1-5% in the indicator composition.

In some implementations, the indicator composition comprises a colorantselected from any of a triarylmethane, azo, or acid dye, preferablyselected from indigo carmine, Acid Blue 1, or FD&C Blue 1, mostpreferably indigo carmine, and the composition further comprises acorrosion inhibitor, preferably sodium carbonate.

In some implementations, the disclosure provides for point of usegeneration of chlorine dioxide, which is unstable in solution and mustprepared fresh for optimal efficacy. Chlorine dioxide may be generatedby channeling into a separate compartment of the dispensing devicesodium hypochlorite, contained in one chamber of a disinfectantcartridge 413, and sodium chlorite contained in a separate chamber ofthe same cartridge 413 and mixed before dispensing onto a disinfectantarticle, such as a wet or dry wipe. Chlorine dioxide can also begenerated by mixing as described above sodium dichloroisocyanurate andsodium chlorite before dispensing onto a dry wipe. Chlorine dioxide canalso be generated by mixing, as described above, sodium chlorite,hydrochloric acid, and water before dispensing onto a dry wipe.

In some implementations, the disclosure provides a single componentindicator composition adapted for use with hypochlorite and troclosenebased disinfectant compositions, the composition comprising at least onecolorant and one or more of abrasins, or surfactants, or rheologymodifiers (thickeners), or bleach activators, or acids, or polyphosphatesalts, or rheology builders, or carbonate salts, or bicarbonate salts,or humectants, or antioxidants, or dispersants, or anti-foaming agents,or solubilizing agents, or stabilizers, or corrosion inhibitors, orwetting agents, or enzymes, or hardeners, or softeners, or coatingagents, or emulsifiers, or oils, or fragrances, optionally comprising asecond component with additional additives as listed above withoutcolorant for better long term storage as additives in either the firstor second components, or both, or optionally as a third aqueouscomponent comprising the one or more additives.

In some implementations, the single or multi-component indicatorcomposition comprises a colorant selected from any of a triarylmethane,azo, or acid dye, preferably selected from indigo carmine, Acid Blue 1,or FD&C Blue 1, in amounts ranging from about 0.001-15% w/v, preferablyfrom about 0.05-2.0% w/v, or from about 0.10-1.0%, or from about0.05-0.50% w/v, or from about 0.10-0.50% w/v, and a rheology modifier.In some implementations the rheology modifier is glycerin. The glycerinmay be present, for example, at about 1-5% in the indicator composition.

In some implementations, the single or multi-component indicatorcomposition comprises a colorant selected from a triarylmethane dye, anazo dye, or an acid dye, preferably selected from indigo carmine, AcidBlue 1, or FD&C Blue 1, and the composition further comprises one ormore of a rheology modifier selected from glycerin, glyceryl stearate,glyceryl oleate, and mixtures thereof; a polymer or copolymer selectedfrom a polyvinyl carboxy polymer crosslinked with ethers ofpentaerythritol (e.g., Carbomer™ 940), an octylacrylamide/acrylatescopolymer, and a poly(acrylic acid) copolymer; a solubilizing agentselected from denatured alcohol, triethanolamine, 2-phenoxyethanol, andmixtures thereof; and an antimicrobial agent such as iodopropynylbutacarbamate. In some implementations, the composition may furthercomprise an opacifying agent selected from mica, titanium dioxide, andmixtures thereof.

In one implementation, a device for use with the multi-componentindicator compositions described here comprises two separatecompartments, the first compartment comprising a disinfectantcomposition in the form of an aqueous solution of sodiumdichloroisocyanurate (“NaDCC” also referred to as “troclosene”) or adisinfectant composition in the form of an aqueous solution of a metalsalt of hypochlorous acid, for example sodium or calcium hypochlorite(NaOCl or Ca(OCl)₂), optionally comprising a pH modulator sufficient tomaintain an alkaline pH of about 10-11; and the second compartmentcomprising at least one colorant and one or more of any abrasins, orsurfactants, or thickeners, or bleach activators, or acids, orpolyphosphate salts, or rheology builders, or carbonate salts, orbicarbonate salts, or humectants, or antioxidants, or dispersants, oranti-foaming agents, or solubilizing agents, or wetting agents, orenzymes, or hardeners, or softeners, or coating agents, or emulsifiers,or oils, or fragrances; and further optionally comprising one or more ofa surfactant or mixture of surfactants, a buffering agent, a stabilizeror corrosion inhibitor, and a perfume or fragrance, in either the firstor second compartments. In some implementations the acidic component maybe formed from citric acid, benzoic acid, acetic acid, and mixturesthereof.

In some implementations, the second compartment comprises an indicatorcomposition comprising an aqueous solution of a colorant selected fromany of a triarylmethane, azo, or acid dye, preferably selected fromindigo carmine, Acid Blue 1, or FD&C Blue 1, most preferably indigocarmine, and a corrosion inhibitor, preferably sodium carbonate.

In some implementations, the disclosure provides a solid or aqueousliquid indicator composition comprising a triarylmethane dye such asbrilliant green or acid green 50, a hydroxide base or mixture thereof,such as NaOH and Ca(OH)₂, and optionally a hypochlorite or troclosenebased disinfectant composition, such as NaDCC, which may furtheroptionally comprise one or more surfactants, either as additives in theindicator composition or the disinfectant composition, or both. In someimplementations, the solid form is in the form of a tablet or powder.

In some implementations, the indicator composition comprises atriarylmethane, azo, or acid dye and either (i) a reducing agent such asformic acid, oxalic acid, citric acid, or ascorbic acid, or (ii) acationic surfactant such as HTAB, SDS, or SXS, and combinations of suchsurfactants, wherein the composition has a fade time of from 30 secondsto 2 minutes or from 30 seconds to 10 minutes after its combination witha hypochlorite based disinfectant composition.

Indicator Compositions for Quaternary Ammonium/Alcohol BasedDisinfectants

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with quaternaryammonium compounds and quaternary ammonium compound/alcohol baseddisinfectant compositions. In some implementations, the multi-componentcomposition comprises at least two separate components, the firstcomponent comprising an aqueous solution of quaternary ammoniumcompounds or alcohol/quaternary ammonium compounds and optionally one ormore catalysts; and a second component comprising at least one colorant;and further optionally comprising one or more additives in either thefirst or second components, or both, or optionally as a third aqueouscomponent comprising the one or more additives. In some implementations,the one or more additives is selected from a surfactant or mixture ofsurfactants, a base, a buffering agent, and a perfume or fragrance.

Generally, multi-component compositions will sequester the colorant in aseparate compartment or reservoir from the catalyst, e.g., separate fromany oxidizing agent and/or reducing agent in the composition. In someimplementations, it is advantageous to provide the optional surfactantas a separate component from the catalyst, especially metal salts, andalso separate from any optional acid in the composition. Inmulti-component compositions comprising an acid and a base, the acid andbase are preferably provided as separate components, i.e., in separatecompartments or reservoirs.

In some implementations, the optional base is added to a component ofthe composition in order to increase the pH of a quaternary ammoniumbased disinfectant composition at its point of use, e.g., after thecomponents of the multi-component composition have been mixed for use indisinfecting a surface. Preferably, the colorant is sequestered in aseparate compartment or reservoir from the base. Some quaternaryammonium based disinfectants perform better at alkaline pH, even thoughthey are less stable at alkaline pH. Accordingly, the multi-componentcompositions described here provide a method to increase the pH of thedisinfectant just prior to use, thereby increasing its effectivenesswithout losing potency. Suitable bases that may optionally be used toincrease the pH of a disinfectant composition include hydroxide basessuch as sodium hydroxide, potassium hydroxide, lithium hydroxide,calcium hydroxide, magnesium hydroxide, ammonium hydroxide, and bariumhydroxide; carbonate and bicarbonate bases such as sodium bicarbonate,bicarbonate, and calcium carbonate; and other bases such as methyl amineand ammonia; and combinations of any of the foregoing.

In some implementations, the catalyst is selected from an oxidizingagent, a reducing agent, a metal salt, and mixtures thereof. Suitableoxidizing agents include peracetic acid, sodium perchlorate, hydrogenperoxide, and bismuth silver oxide, preferably hydrogen peroxide.Suitable reducing agents include a reducing sugar, water, hydrogen gas,metals, dithionates, thiosulfates, formic acid, oxalic acid, cyanides,hydrazine, iodide salts, sodium dithionite stabilized by sodium sulfite,maltose monohydrate, citric acid, thiourea dioxide, riboflavin,hydroquinone, and ascorbic acid. Preferably, the reducing agent isselected from ascorbic acid, sodium sulfite, dithionite and sodiumsulfite, maltose monohydrate, and combinations thereof. Suitable metalsalts are those described above, namely those in which the metal salthas an oxidation state of +1, +2, or +3, preferably +2. In someimplementations, the metal salt is an iron, copper, zinc, or magnesiumsalt, preferably an iron salt.

In some implementations, the disclosure provides a device configured toapply a single or multi-component indicator composition as describedherein, and a quaternary ammonium salts-based disinfectant compositiononto a disinfectant article, such as a wipe, where the article has notbeen pre-saturated with the disinfectant composition. This configurationis particularly advantageous where the fabric of the disinfectantarticle affects the disinfectant active ingredient over time and reducesits shelf-life compared to the disinfectant in solution alone. Forexample, quaternary ammonium salts-based disinfectants lose potency whenexposed to cellulosic wipe materials, and for that reason are insteadoften packaged with polypropylene wipes.

TABLE 1 Representative Examples for Quaternary Ammonium or Alcohol baseddisinfectants Fade Time Colorant Catalyst(s) Optional Additive(s) (min)1 acid dyes, e.g., Oxidizing agent, e.g., Surfactants, e.g., CTAB3:30-5:00 acid green 25 hydrogen peroxide and metal Acid, pH 0-6.9 or0-7 salt, e.g., Fe²⁺ salts 2 thiazine dyes, e.g., Reducing agent, e.g.vitamin Surfactant, e.g., CTAB and 2:00 methylene blue, E, nicotinamideSDS toluidine blue O, Acid, pH 0-6.9 or 0-7 azure blue 3 acid dyes,e.g., Oxidizing agent, e.g., Surfactants, e.g., CTAB, 20:00-40:00 acidgreen 25, hydrogen peroxide Tergitols direct blue 86, acid Base, e.g.,bicarbonate, red 1 hydroxide, pH 7-14 4 indigo carmine, Oxidizing agent,e.g., Base, e.g., hydroxide, 20:00-40:00 other similar hydrogen peroxidepH 7-14 organic salts 5 anthraquinone dye, Oxidizing agent, e.g., Base,e.g., bicarbonate, pH  1:00-15:00 e.g., remazol blue hydrogen peroxideand metal 7-14 salt, e.g., Fe2²⁺ salts 6 thiazine dyes, e.g., Reducingagent, e.g. Base, e.g., hydroxide, 20:00-40:00 methylene blue,riboflavin pH 7-14 toluidine blue O, azure blue 7 cationic dye, e.g.,Oxidizing agent, e.g., Surfactant, e.g., CTAB and 2:30-5:00 astrazonpink, hydrogen peroxide and metal SDS methyl green salt, e.g., Fe²⁺salts Acid, pH 0-6.9 or 0-7 and/or Reducing agent, e.g., sodiumdithionite and sodium sulfite 8 triarylmethane dye, Base, e.g.,hydroxide, Surfactants, e.g., CTAB 2:00-5:00 e.g., brilliant green, pH7-14 (brilliant acid green 50 green) 10:00- 40:00 (acid green 50) 9leuco dye, e.g., Reducing agent, e.g., sodium Base, e.g., hydroxide,0:30-8:00 crystal violet dithionite and sodium sulfite pH 7-14 lactone10 azo dyes, e.g., Oxidizing agent, e.g., Base, e.g., bicarbonate,20:00-40:00 orange II, hydrogen peroxide hydroxide, pH 7-14 amaranth,napthol green 11 cationic dye, e.g., Oxidizing agent, e.g., Surfactant,e.g., CTAB and 1:30-3:00 astrazon red, hydrogen peroxide SDS astrazonpink Base, e.g., bicarbonate, pH 7-14 12 triarylmethane dye, Reducingagent, e.g., sodium 2:00 e.g., brilliant green, dithionite and sodiumsulfite crystal violet 13 triarylmethane and Oxidizing agent, e.g.,metal Base, e.g., hydroxide,  2:00-15:00 thiazine dyes, e.g., salt,e.g., Cu²⁺ salts pH 7-14 FD&C Blue 1, methylene blue 14 fluorone dye,e.g., Oxidizing agent, e.g., Acid, pH 0-6.9 or 0-7 8:00-9:00 rhodamine bhydrogen peroxide and metal salt, e.g., Fe²⁺ salts 15 triarylmethane,Oxidizing agent, e.g., Base, e.g., hydroxide or 0:30-5:00 azo, or aciddyes hydrogen peroxide bicarbonate, pH 7-14 e.g., acid blue 1,Surfactant, e.g., CTAB and brilliant green, acid SDS blue 83 16 thiazinedyes, e.g., Oxidizing agent, e.g., metal Base, e.g., hydroxide,20:00-40:00 methylene blue, salt, e.g., Fe²⁺ salts pH 7-14 toluidineblue O, azure blue 17 leuco dye, e.g., alcohol 00:45  crystal violetlactone 18 inorganic alcohol Acid, pH 0-6.9 or 0-7 2:00-3:00 compoundssuch as Surfactants, e.g., CTAB potassium permanganate

In some implementations, the catalyst is an oxidizing agent, preferablyhydrogen peroxide, the colorant is a water-soluble oxidizable dye,preferably selected from an azo dye, a triarylmethane dye, and an aciddye, and one or more components of the composition further comprises abase, such as a hydroxide base, sufficient to maintain an alkaline pH ofthe point of use composition.

In some implementations, the catalyst is a combination of an oxidizingagent, preferably hydrogen peroxide, a reducing agent, preferably sodiumdithionite and sodium sulfite, and a metal salt, preferably an iron saltsuch as iron sulfate, and the colorant is a cationic dye, such asAstrazon Pink or Astrazon Red.

In some implementations, the composition comprises hydrogen peroxide asthe catalyst, a cationic dye such as Astrazon Pink or Astrazon Red, asurfactant, and an alkaline salt such as sodium triphosphate, alsoreferred to as sodium tripolyphosphate (STPP).

In some implementations, the catalyst may comprise a strong base, a weakbase, or a combination of strong and/or weak bases.

In some implementations, the indicator composition comprises atriarylmethane, azo, or acid dye, a catalyst, preferably hydrogenperoxide, and a base, preferably a hydroxide or bicarbonate basesufficient to maintain an alkaline pH, wherein the composition has afade time of from 1-2 minutes.

In some implementations, the indicator composition comprises a cationicdye, a catalyst, such as hydrogen peroxide or a metal salt, andcombinations of such catalysts, and one or more of a reducing agent,such as sodium dithionite and sodium sulfite, citric acid, or ascorbicacid, and combinations of such reducing agents, and a cationicsurfactant such as HTAB, SDS, or SXS, and combinations of suchsurfactants, wherein the composition has a fade time of from 2-4minutes.

In some implementations, the indicator composition comprises a cationicdye, a catalyst, preferably hydrogen peroxide, and a base, preferably ahydroxide or bicarbonate base sufficient to maintain an alkaline pH, asurfactant, preferably a nonionic surfactant such as a polyglycol ether,a cationic surfactant, such as HTAB, and combinations of suchsurfactants, wherein the composition has a fade time of from 1-3minutes.

In some implementations, the catalyst comprises or consists of a base,for example, where the colorant is a triarylmethane dye, such asbrilliant green or acid green 50, a base is sufficient to fade the dyeto clear, with stronger bases reducing the fade time. For othercolorants, where an oxidizing or reducing agent provides the maincatalyst, additional base may be added to reduce the fade time.

In some implementations, the catalyst is provided by the disinfectantcomposition, or a component thereof, for example alcohol in anoptionally acid environment will fade the color of inorganic compoundssuch as potassium permanganate; and alcohol will fade the color of leucodyes such as crystal violet and lactone.

Generally, the desired fade time is achieved by modulating theconcentrations and volumes of the catalyst, however the concentrationand volume of the colorant may also be used to affect fade time.

Indicator Compositions for Hydrogen Peroxide Based Disinfectants

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with a hydrogenperoxide based disinfectant solution, for example aqueous solutions offrom about 0.01 to 75% w/v hydrogen peroxide, preferably from about 0.1to 10% w/v, from 0.1 to 5% w/v, or from 0.1 to 2% w/v hydrogen peroxide.In some implementations, the multi-component composition comprises atleast two separate components, the first component comprising a colorantand the second component comprising a catalyst effective to generatehydroxyl radicals in the presence of hydrogen peroxide. Such radicalsare short-lived but powerful oxidizers. Accordingly, the disclosure alsoprovides methods of disinfecting and/or decontaminating a surface thatboth increases the strength of a hydrogen peroxide based disinfectantand provides a visible indicator of the completeness of the disinfectionand/or decontamination. In some implementations, the multi-componentcomposition comprises at least two separate components, the firstcomponent comprising a colorant, and the second component comprising acatalyst and/or additional hydrogen peroxide. The single ormulti-component composition may further optionally comprise one or moreoptional additives in either the first or second components, or both, oroptionally as a third aqueous component comprising the one or moreadditives. In some implementations, the one or more additives isselected from a surfactant or mixture of surfactants, a base, abuffering agent, and a perfume or fragrance.

In some implementations, the colorant is selected from a triarylmethanedye, such as lissamine green, a synthetic basic dye, an anthraquinonedye, a nitroso dye, and a double azo dye. In some implementations, thecolorant is a dye having at least two aromatic rings connected by atleast one covalent bond, preferably an ethyl moiety, for example indigocarmine, quinoline yellow, crysophenine, astrazon pink, astrazon red, orRhodamine B. In some implementations the colorant is selected fromastrazon pink, indigo carmine, orange II, FD&C Blue, lissamine green,brilliant green, methylene blue, remazol blue, bromophenol blue, acidblue, naphtol green, crystal violet lactone, and quinoline yellow.

In some implementations, the one or more catalysts is selected from astrong base, a weak base, a combination of strong and/or weak bases, anoxidizing agent, a reducing agent, and a metal salt. In someimplementations, the strong base is selected from potassium hydroxide(KOH), sodium hydroxide (NaOH), lithium hydroxide (LiOH), rubidiumhydroxide (RbOH), cesium hydroxide (CsOH), calcium hydroxide (Ca(OH)₂),strontium hydroxide (Sr(OH)₂), magnesium hydroxide (Mg(OH)₂), and bariumhydroxide (Ba(OH)₂), preferably KOH, NaOH, LiOH, or Ca(OH)₂. In someimplementations, the weak base is selected from a base having a pK_(b)of less than 7, preferably any bicarbonate salt, any carbonate salt,methyl amine, hydroxides of quaternary ammonium cations or other organiccations, pyridine, aniline, imidazole, histidine, benzimidazole, anyphosphazene base, and any nucleobase.

In some implementations, the catalyst comprises a metal salt in whichthe metal salt has an oxidation state of +1, +2, or +3, preferably +2.In some implementations, the metal salt is an iron, copper, zinc, ormagnesium salt, preferably an iron salt. In some implementations, themetal salt is a sulfate, nitrate, bromide, chloride, gluconate, sulfide,fumarate, oxide, iodide, fluoride, acetate, oxalate, stearate,diethyldithiocarbamate, ethoxide, citrate, trifluoromethanesulphonate,or cyanide salt. In some implementations, the metal salt is a sulfate,nitrate, bromide, chloride, or fluoride salt. In some implementations,the metal salt is anhydrous or hydrated, preferably a mono-, di-, tri-,penta-, hexa-, hepta-, nona-hydrate salt. In implementations where aweak metal salt catalyst is used, such as copper, zinc, or magnesium,the composition may further comprise an optional reducing agent whichserves to replenish the metal catalyst by returning it to a loweroxidation state. In some implementations, the metal salt is FeSO₄. Insome implementations, the amount of the metal salt in the composition isadapted to provide a final concentration of the metal catalyst in therange of from about 0.001 to 20 M, preferably from about 0.010 to 0.100M, or from 0.015 to 0.075 M.

In some implementations, the catalyst comprises a reducing agent. Insome implementations, the reducing agent is selected from one or more ofa reducing sugar, a dithionate, a thiosulfate, formic acid, oxalic acid,cyanides, hydrazine, iodide salts, sodium dithionite stabilized bysodium sulfite, maltose monohydrate, citric acid, thiourea dioxide,riboflavin, hydroquinone, and ascorbic acid.

In some implementations, the catalyst comprises an oxidizing agent. Insome implementations, the oxidizing agent is selected from one or moreof a peroxide, oxone, bleach, riboflavin, nitrate salts, persulfatesalts, dichromate salts, and nitrite salts. In some implementations theoxidizing agent is selected from oxone and additional hydrogen peroxide,that is in addition to that of the disinfectant composition itself withwhich the indicator composition is mixed at point of use.

In some implementations, the optional surfactant is selected from one ormore of a one or more of a nonionic surfactant, such as a polyglycolether, tetramethyl decynediol, and cocomonoisopropanolamide; an anionicsurfactant such as alkyldiphenyloxide disulfonate, sodium lauryl sulfate(SLES), and Stepanol™ WA-100; and a cationic surfactant such ashexadecyltrimethylammonium bromide (HTAB), which may also be referred toas cetylmethylammonium bromide (CTAB). In some implementations, thesurfactant is sodium xylene sulfonate (SXS) or sodium toluene sulfonate(STS). In some implementations, the surfactant is sodium dodecyl sulfate(SDS), sodium xylene sulfonate (SXS), and mixtures thereof.

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with a hydrogenperoxide based disinfectant solution comprising a colorant, a metalcatalyst, and a reducing agent, and optionally one or more surfactantsand an additional oxidizing agent in the form of additional hydrogenperoxide. In some implementations, the single or multi-componentindicator composition comprises a colorant such as indigo carmine, ametal catalyst such as cupric sulfate pentahydrate/ferrous sulfateanhydrous or heptahydrate, a reducing agent such as maltose monohydrateor citric acid, preferably maltose monohydrate, an additional oxidizingagent in the form of additional hydrogen peroxide, and optionally one ormore surfactants selected from SDS, SXS, and mixtures thereof.

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with a hydrogenperoxide based disinfectant solution comprising a colorant, a metalcatalyst, such as an Fe′ salt, and a pH modulator adapted to maintainthe metal catalyst in an acidic aqueous solution of pH 5, preferably pHless than 3, and optionally one or more of a reducing agent, and anadditional oxidizing agent. In some implementations, the colorant isselected from astrazon pink, orange II, triarylmethane dye, andquinoline yellow. In some implementations, the single or multi-componentindicator composition adapted to color an aqueous solution of from about0.01 to 75% w/v hydrogen peroxide, preferably from about 0.1-11% w/v,from 0.1-6% w/v, or from 0.1-3% w/v hydrogen peroxide, such that thecolor fades to clear within about 30 seconds to 30 minutes, or 1-30minutes, upon application of the colored hydrogen peroxide solution to asurface. In some implementations, the color fades to clear within about30 seconds to 1 minute, or within about 2-15 minutes, or about 10-30minutes.

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with a hydrogenperoxide based disinfectant solution comprising a colorant, a metalcatalyst, such as an Fe′ salt, and a pH modulator, such as an acid orcombination of acids, adapted to maintain the metal catalyst in anacidic aqueous solution of pH 5, preferably pH less than 3, andoptionally comprising an additional oxidizing agent. In someimplementations, the colorant is selected from brilliant green,methylene blue, remazol blue, bromophenol blue, acid blue, naphtholgreen, and crystal violet lactone.

In some implementations, the disclosure provides an article ofmanufacture comprising the single or multi-component indicatorcompositions described herein, either in a single compartment, orcontained within two or more separate compartments or chambers, whichare adapted to be mixed upon together to form a single componentindicator composition at the point of use, as described above. Forexample, the article may further comprise a tubing and nozzle systemthat allows contents from different compartments to communicate into asingle solution before communicating with the disinfectant.

In some implementations, a multi-component composition is providedwherein each of at least two components is provided in physicallyseparate reservoirs or chambers, one containing a hydrogen peroxidesolution and a separate chamber containing a catalyst, such as a metalsalt, for example, FeSO₄, in an aqueous solution. In someimplementations, the two components are contained in a cartridge 413adapted to fit within a device as described here and may be dispensedsimultaneously onto a disinfectant article, such as a wipe.Alternatively, the hydrogen peroxide solution and the catalyst solutioncan be fed from their respective chambers into a mixing chamber withinthe cartridge 413 or device before dispensing onto the disinfectantarticle. In a further implementation, the hydrogen peroxide solution andthe metal catalyst solution may be dispensed sequentially onto thearticle. As described above and illustrated in Table 2 below, othermetal salts are suitable catalysts, including for example salts of Zn²⁺,Co²⁺, Cu²⁺, Ni²⁺, Mn²⁺, and Cr³⁺.

TABLE 2 Representative Examples for Hydrogen Peroxide BasedDisinfectants. Fade Time Colorant Catalyst(s) Optional Additive(s) (min)1 azo dyes, e.g., Oxidizing agent, e.g., metal Acidic agent or buffer atpH  2:00-15:00 orange II salt, e.g., Fe²⁺ salts 3 or pH 1.5 2 indigocarmine, Oxidizing agent, e.g., metal Acidic agent or buffer at pH20:00-40:00 other similar salt, e.g., Fe²⁺ or Zn²⁺ salts 3 or pH 1.5organic salts and Reducing agent, e.g., magnesium gluconate 3triarylmethane dye, Oxidizing agent, e.g., Fe²⁺ Acidic agent or bufferat pH  2:00-15:00 e.g., lissamine salts 3 or pH 1.5 green 4 thiazinedyes, e.g., Oxidizing agent, e.g., Acidic agent or buffer at pH 2:00-10:00 methylene blue, hydrogen peroxide* 3 or pH 1.5 toluidineblue O, azure blue 5 brilliant green Oxidizing agent, e.g., Fe²⁺ Acidicagent or buffer at pH  1:00-30:00 methylene blue salts 3 or pH 1.5remazol blue and hydrogen peroxide* bromophenol blue acid blue 113naphthol green crystal violet lactone 6 triarylmethane dye, Oxidizingagent, e.g., Fe²⁺ Acidic agent or buffer at pH 11:00 e.g., FD&C Bluesalts and oxone 3 or pH 1.5 7 indigo carmine, Oxidizing agent, e.g.,Surfactant, e.g., SXS, SDS 1:00-1:30 other similar hydrogen peroxide*Base, e.g., hydroxide, organic salts bicarbonate, and mixtures thereof 8indigo carmine, Oxidizing agent, e.g., metal Surfactant, e.g.,Tergitols, 0:45-1:15 other similar salt, e.g., Cu²⁺ salts, SXS, SDS0:45-2:30 organic salts hydrogen peroxide* Acidic agent or buffer at pHwith pH 3 and 3 or pH 1.5 buffer Reducing agent, e.g., sodium 0:45 withdithionite and sodium sulfite, pH 1.5 maltose, an acid or buffercombination of acids, hydroquinone 9 acid green 50, Oxidizing agent,e.g., Fe²⁺ Acidic agent or buffer at pH 20:00-40:00 amaranth salts 3 orpH 1.5 Surfactant, e.g., CTAB 10 quinoline yellow Oxidizing agent, e.g.,Fe²⁺ Acidic agent or buffer at pH 10:00-30:00 salts 3 or pH 1.5 11triarylmethane dye, Oxidizing agent, e.g., Base, e.g., hydroxide20:00-40:00 e.g., brilliant green hydrogen peroxide* or Reducing agent,e.g., riboflavin 12 cationic dye, e.g., Oxidizing agent, e.g., metalAcidic agent or buffer at pH  1:00 astrazon pink salt, e.g., Fe²⁺ salts3 or pH 1.5 *hydrogen peroxide may be additional, as a component of amulti-component composition, or it may be provided by the disinfectantcomposition, or both.

In some implementations, the composition comprises a colorant that is anorganic salt, such as indigo carmine or a similar organic salt, acatalyst, preferably hydrogen peroxide or a metal salt, or a combinationof such catalysts, and further comprising a nonionic surfactant,preferably a polyglycol ether, a cationic surfactant, preferably SDS,SXS, or a combination of such surfactants, a reducing agent, such assodium dithionite and sodium sulfite, maltose monohydrate, citric acid,hydroquinone, or ascorbic acid, and combinations of such reducingagents, wherein the composition has a fade time of from 30 seconds to 2minutes.

In some implementations, the composition comprises a colorant that is anorganic salt, such as indigo carmine or a similar organic salt, acombination of catalysts including hydrogen peroxide and a metal salt,preferably a copper salt such as copper sulfate (Cu(II)SO₄), a cationicsurfactant, preferably SDS or a combination of SDS and SXS, and areducing agent, preferably maltose monohydrate.

In some implementations, the composition comprises a colorant that is anorganic salt, such as indigo carmine or a similar organic salt, acombination of catalysts including hydrogen peroxide and one or moremetal salts, preferably a copper salt such as copper sulfate (Cu(II)SO₄)and/or an iron salt such as iron sulfate (Fe(II)SO₄), a surfactantselected from a cationic and nonionic surfactant, such as SDS, SXS,tergitol, and mixtures thereof, and a reducing agent selected frommaltose monohydrate, citric acid, and mixtures thereof.

Indicator Compositions for Peracetic Acid Based Disinfectants

In some implementations, the disclosure provides a single ormulti-component indicator composition adapted for use with peraceticacid based disinfectant compositions. In some implementations, themulti-component composition comprises at least two separate components,the first component comprising an aqueous solution of peracetic acid;and a second component comprising at least one colorant and one or morecatalysts; and further optionally comprising one or more optionaladditives in either the first or second components, or both, oroptionally as a third aqueous component comprising the one or moreadditives. In some implementations, the one or more additives isselected from a surfactant or mixture of surfactants, a base, abuffering agent, and a perfume or fragrance.

In accordance with this embodiment, it is noted that certain surfactantsmay act in a dual role as catalysts via the generation of hydroxylradicals, for example, cetylmethylammonium bromide (CTAB).

As with chlorine dioxide, peracetic acid is known to degrade rapidly insolution, and peracids and peroxides are known to decompose even fasterin solution when incorporated into a disinfectant article, such as a wetwipe. Accordingly, in some implementations, the disclosure provides forpoint of use generation of peracetic acid by combining acetic acid andhydrogen peroxide. For example, in a disinfectant dispensing cartridge413, one reservoir chamber can contain acetic acid and the otherreservoir chamber can contain hydrogen peroxide that when mixed such asby channeling into a mixing compartment, generate peracetic acid readyfor dispensing onto a disinfectant article, such as wet or dry wipe.Peracetic acid also can be released from certain solid compounds, forexample, peracetyl borate (PAB). Dry wipes embedded with PAB or someother peracetic acid-releasing solid may be dispensed through the devicedescribed herein. For example, the device can add water and/or solventat the indicator to activate the solid peracetic acid.

TABLE 3 Representative Examples for Peracetic Acid Based DisinfectantsFade Time Colorant Catalyst(s) Optional Additive(s) (min) 1 indigocarmine, Oxidizing agent, e.g., metal Reducing agent, e.g., citric0:30-1:00 other similar salt, e.g., Cu²⁺ salts, Fe²⁺ acid, ascorbic acidorganic salts salts 2 quinophthalone 1:00 pigments, e.g., quinoloneyellow 3 triarylmethane Oxidizing agent, e.g., metal Surfactant, e.g.,CTAB  0:30-10:00 dyes, acid dyes, salt, e.g., Cu²⁺ salts, Fe²⁺ e.g.,acid green salts 50, FD&C blue, acid green 25 4 triphenylmethaneSurfactant, e.g., CTAB 5:00 dyes, e.g., patent blue V 5 organoiodine2:00 compounds, e.g., erythrosine supra (red no. 3)

In some implementations, the indicator composition comprises an aciddye, such as acid green and a surfactant.

In some implementations, the indicator composition comprises an aciddye, such as acid green, e.g., Acid Green 25 or Acid Green 50, or AcidBlue 1, and a surfactant, preferably CTAB.

In some implementations, the indicator composition comprises an organicsalt such as indigo carmine, a catalyst, preferably a metal salt, and areducing agent, preferably citric acid, ascorbic acid, and combinationsthereof, wherein the composition has a fade time of from 3-10 minutes.

Hand Sanitizer Compositions

In some implementations, a single or multi-component indicatorcomposition as described here can be adapted for use with a hand soap orsanitizer, including liquid soaps, alcohol-based hand rubs, handsanitizer foams, etc., to impart transient color to the soap orsanitizer and allow its visualization following application to skin orglove surfaces. The indicator composition may be mixed directly with aconventional hand soap or sanitizer solution, for example by actuationof the device housing the soap/sanitizer and indicator composition atpoint-of-use. In some implementations, the disclosure provides anarticle of manufacture in the form of a dispenser comprising a pumpelement, the dispenser adapted to hold the indicator composition in oneor more containers or reservoirs. The dispenser article may be adaptedto as a replacement or attachment that replaces or attaches to acontaining holding the soap/sanitizer composition. In accordance withthis implementation, the dispenser article dispenses an amount of theindicator composition to the soap/sanitizer upon actuation, for examplevia channels, reservoirs, etc. In some embodiments, the dispenserarticle is adjustable so that it can be adapted to fit different sizedcontainers of hand soap/sanitizer. In some embodiments, the dispenserarticle may further include a switch mechanism adapted to place thedispenser article into an “active” or “inactive” configuration, whichconfigurations either allow or block the addition of the indicatorcomposition to the soap/sanitizer upon actuation of the device, therebyenabling the user to select whether the dispensed hand soap or sanitizeris colored or remains uncolored.

In some implementations, the disclosure also provides a compositionadapted to impart a permanent color rather than a transient color. Suchcompositions may be used, for example, in a training environment toprovide a visual record of a user's efficiency in applying thedisinfectant composition, for example to a glove or other disposableitem. In some implementations, these compositions may also comprise oneor more of a surfactant, a thickener, a rheology builder, a humectant, adispersant, an abrasin, a fragrance, aromatic oil, or perfume, ahardener, a softener, a wax, an emulsifier, and a coating agent. In someimplementations, the colorant is a color-producing organic salt or acid.

Exemplary indicator compositions for use with alcohol-based handsanitizers include 0.01-5% colorant, and an optional additive such as asurfactant, thickening agent, e.g., glycerin, and a pH modulator, suchas an alkaline builder, e.g., sodium hydroxide or potassium hydroxide,and mixtures thereof. In some implementations, the composition furthercomprises a catalyst. In some implementations, the catalyst is selectedfrom hexadecyltrimethylammonium bromide (HTAB or CTAB), copper (II)sulfate pentahydrate, and iron (III) nitrate nonahydrate. In someimplementations, the colorant may be selected from a triarylmethane dyesuch as FD&C Blue #1, a phenol dye such as phenolphthalein,thermochromic 32, and Celsius blue dye, and combinations thereof. Insome implementations, the colorant is selected from FD&C Blue #1, fastgreen FCF, erythrosine, allura red AC, tartrazine, sunset yellow FCF,indigo carmine, ultramarine, cobalt blue, phthalocyanine, and CoomassieBrilliant Blue, Acid Green 25, Bromothymol Blue, Acid Green 50, AcidBlue 80, Remazol Brilliant Blue R, crystal violet lactone, patent blueV, thymolphthalein, rhodamine B, acid orange 7, astrazon red, astrazonpink, or a mixture of one or more thereof. In some implementations thesurfactant is selected from sodium dodecyl sulfate, sodiumdodecylbenzenesulfonate, hexadecyltrimethylammonium bromide (HTAB orCTAB), sodium 3,4-dichlorobenzoate, sodium laureth sulfate, sodiumxylene sulfonate, and sodium toluene sulfonate.

In some implementations, the indicator composition is a non-fadingcomposition. In one implementation, the non-fading composition comprisesor consists of a colorant selected from Acid Orange II, Astrazon Pink,Astrazon Red, Acid Blue 1, and FD&C Blue 1, and a surfactant, preferablySDS.

As discussed above, in some implementations the dispenser article isadapted as a replacement or attachment that replaces or attaches to acontaining holding the soap/sanitizer composition. In someimplementations, the dispenser article adapted for attachment comprisesa funnel with a top opening and a bottom opening, the funnel having areservoir for holding an indicator composition as described herein; andan adhesive ring deposed at the top end of the funnel attachment. Thefunnel is affixable to the liquid dispenser through the adhesive ringsuch that when the liquid dispenser dispenses an aliquot of the liquid,it is captured through the top opening of the funnel and travels throughthe indicator composition so as to emerge from the bottom opening of thefunnel having been imbued with a colorant.

In some implementations, the dispenser article is a motion-activatedhand sanitizer dispenser. In some implementations, the adhesive ring iscircular. In certain embodiments, the adhesive ring is not circular. Insome implementations, the funnel attachment is affixed to the liquiddispenser through a clamp.

In some implementations, dispenser article is a pump dispenser fordispensing a liquid. The pump dispenser includes: a piston chamber; apiston housed in the piston chamber, the piston is characterized by ahabitual position and a depressed position when pressed; a firstreservoir for holding the liquid to be dispensed, the first reservoircomprising: an inlet for fluid communication between the piston chamberand the first reservoir, and an outlet for fluid communication out ofthe piston chamber; a second reservoir for holding an additivecomposition, the second reservoir comprising: an inlet for fluidcommunication between the piston chamber and the second reservoir, andan outlet for fluid communication out of the second reservoir; and aspring attached to the piston. The spring is depressed when a pressureis applied to the piston and returns the piston to the habitual positionupon relief of the pressure. The pump dispenser is configured such thata movement of the piston from the habitual position to the depressedposition causes the liquid to be dispensed to move from the firstreservoir to the piston chamber, from the piston chamber to the secondreservoir, and eventually exiting the second reservoir.

EQUIVALENTS

Those skilled in the art will recognize or be able to ascertain using nomore than routine experimentation, many equivalents to the specificembodiments of the invention described herein. Such equivalents areintended to be encompassed by the following claims.

All references cited herein are incorporated herein by reference intheir entirety and for all purposes to the same extent as if eachindividual publication or patent or patent application was specificallyand individually indicated to be incorporated by reference in itsentirety for all purposes.

The present invention is not to be limited in scope by the specificembodiments described herein. Indeed, various modifications of theinvention in addition to those described herein will become apparent tothose skilled in the art from the foregoing description and accompanyingfigures. Such modifications are intended to fall within the scope of theappended claims.

1-69. (canceled)
 70. A device for applying a composition to a wipedispensed through the device, the device comprising: a housing at leastpartially surrounding an interior volume and comprising: (i) an exteriorwall defining a dispensing aperture extending through the exterior wall;(ii) a lower end region comprising an opening through which at least onewipe of a plurality of wipes is drawn into the interior volume of thehousing from a canister holding the plurality of wipes; and (iii) one ormore connecting features on the lower end region; a dispensing mechanismpositioned within the interior volume of the housing, the dispensingmechanism comprising a plurality of rollers configured to capture anddirect the at least one wipe through the interior volume of the housingtowards the dispensing aperture; an application mechanism positionedwithin the interior volume of the housing relative to the dispensingaperture; a processor in operative communication with a sensor and aninput, the sensor configured to communicate to the processor informationrelated to the at least one wipe directed towards the dispensingaperture; and a removable cartridge configured to be coupled to thehousing, the cartridge comprising: a cartridge housing defining areservoir; and a penetrable barrier extending through a portion of thehousing; wherein the reservoir comprises a first chamber sized tocontain a first composition, a second chamber sized to contain a secondcomposition, and a third chamber sized to contain a third composition.71. The device of claim 70, wherein the processor is configured tomonitor, analyze, and record in a memory of the device the information.72. The device of claim 70, wherein the processor is configured tocontrol automatically at least one function of the device based on theinformation.
 73. The device of claim 70, wherein the informationcommunicated from the sensor to the processor is synchronized with atime log.
 74. The device of claim 73, wherein the informationsynchronized with the time log indicates productivity of a user and/oractivity of the device.
 75. The device of claim 70, wherein theinformation communicated from the sensor to the processor is analyzed bysoftware program running on the processor.
 76. The device of claim 70,wherein the information communicated from the sensor indicates a numberof the plurality of wipes dispensed through the dispensing aperture. 77.The device of claim 76, wherein the number of the plurality of wipesdispensed is based on an amount time spent actuating the input of thedevice.
 78. The device of claim 76, wherein the number of the pluralityof wipes dispensed is based on a number of revolutions made by theplurality of rollers.
 79. The device of claim 76, wherein the number ofthe plurality of wipes dispensed is based on perforations between eachof the plurality of wipes dispensed detected by the sensor.
 80. Thedevice of claim 76, wherein the number of the plurality of wipesdispensed is synchronized with a time log.
 81. The device of claim 70,wherein the information communicated from the sensor to the processorindicates timing between when a first wipe of the plurality of wipes isdispensed and a second wipe of the plurality of wipes is dispensed. 82.The device of claim 70, wherein the information communicated from thesensor to the processor indicates a frequency of wipes dispensed overtime.
 83. The device of claim 70, wherein the information communicatedfrom the sensor to the processor indicates when multiple wipes aredispensed simultaneously.
 84. The device of claim 70, wherein the sensoris an optical sensor or a mechanical sensor.
 85. The device of claim 70,wherein the information communicated is a presence of the at least onewipe of the plurality of wipes within the dispensing aperture.
 86. Thedevice of claim 85, wherein at least a portion of the at least one wipeinterfaces with the sensor.
 87. The device of claim 70, wherein thedevice further comprises a movable, mechanical cover located relative tothe dispensing aperture that is configured to interface with the sensor.88. The device of claim 87, wherein the information communicated by thesensor is displacement of the cover relative to the dispensing aperture.89. The device of claim 87, wherein the processor is programmed toinactivate one or both of the application mechanism and the dispensingmechanism based on the information communicated from the sensor.
 90. Thedevice of claim 87, wherein the information communicated from the sensorindicates the cover is displaced and has not moved for a period of time.91. The device of claim 90, wherein the processor is programmed to causethe plurality of rollers to automatically withdraw the at least one wipeof the plurality of wipes away from the dispensing aperture after theperiod of time.
 92. The device of claim 90, wherein the period of timeis between 10 seconds and 30 seconds, between 30 seconds and 1 minute,between 1 minute and 2 minutes, between 1 minute and 5 minutes, between1 minute to about 20 minutes, or between 1 minute to about 60 minutes.93. The device of claim 90, wherein the device further comprises a userinterface and the period of time is programmable by a user on the userinterface.
 94. The device of claim 70, wherein the sensor comprises afirst sensor configured to interface with the at least one wipe of theplurality of wipes within the dispensing aperture and the device furthercomprises a second sensor configured to interface with a movable,mechanical cover located relative to the dispensing aperture.
 95. Thedevice of claim 70, wherein the exterior wall of the housing forms anupper surface of the device or a side surface of the device.
 96. Thedevice of claim 70, wherein the lower end region of the housing is sizedto couple to the canister holding the plurality of wipes.
 97. The deviceof claim 96, wherein the one or more connecting features on the lowerend region are configured to removably couple the lower end region tothe canister.
 98. The device of claim 96, wherein when the device iscoupled to the canister, an interior of the canister is in fluidcommunication with the interior volume of the housing through theopening.
 99. The device of claim 96, wherein the device forms aremovable lid for the canister.
 100. The device of claim 70, furthercomprising an adapter comprising a first lip on an upper region of theadapter and a second lip on a lower region of the adapter, wherein thefirst lip is sized to reversibly couple to the lower end region of thehousing and the second lip is sized to reversibly couple to thecanister.
 101. The device of claim 100, wherein the one or moreconnecting features on the lower end region of the housing areconfigured to removably couple the lower end region of the housing to anadapter.
 102. The device of claim 100, wherein the adapter comprises asensor configured to interface with one or both of the device and thecanister.
 103. The device of claim 70, wherein the sensor of the deviceis configured to interface with a corresponding element on the canisterholding the plurality of wipes.
 104. The device of claim 103, whereinthe sensor of the device is a mechanical sensor or an optical sensor.105. The device of claim 103, wherein the corresponding feature on thecanister is a tactile series of ridges and bumps forming a codeconfigured to be detected by the sensor.
 106. The device of claim 105,wherein the code provides information about the plurality of wipescontained within the canister.
 107. The device of claim 105, wherein thecode delineates one or both of a chemistry of the plurality of wipes andwipe dimension.
 108. The device of claim 70, wherein the compositions inthe first, second or third chambers are the same compositions, differentcompositions, or components of a single composition.
 109. The device ofclaim 70, wherein the cartridge comprises a sensor configured to detectliquid volume within the reservoir of the cartridge.
 110. The device ofclaim 109, wherein the sensor of the cartridge is an optical sensor or amechanical sensor.
 111. The device of claim 70, wherein the reservoir isrefillable.
 112. The device of claim 70, wherein the compositions in thefirst, second and/or third chambers are the same compositions ordifferent compositions.
 113. The device of claim 112, wherein theapplication mechanism is configured to apply the first, second, andthird composition to the at least one of the plurality of wipes. 114.The device of claim 112, wherein the application mechanism is configuredto apply the first, second, and third compositions simultaneously. 115.The device of claim 112, wherein the application mechanism is configuredto apply the first, second, and third compositions.
 116. The device ofclaim 112, wherein the application mechanism comprises a firstapplicator for the first composition, a second applicator for the secondcomposition; and a third applicator for the third composition.
 117. Thedevice of claim 116, wherein the first, second, and third applicatorsare arranged to dispense in parallel, in series, or in combination. 118.The device of claim 112, wherein the first composition comprises acolorant selected from any of a triarylmethane, azo, indigoid, or aciddye; optionally further comprising an acidic agent or acidifying agent,a corrosion inhibitor, or both an acidic agent or acidifying agent and acorrosion inhibitor.
 119. The device of claim 118, wherein the secondcomposition is a hypochlorite based disinfectant composition, optionallyfurther comprising a surfactant or rheology modifier, or both.
 120. Thedevice of claim 112, wherein the application mechanism comprises atleast one applicator; and a transfer element including a pump.
 121. Thedevice of claim 120, wherein the transfer element transfers the amountof the first and second compositions from the reservoir towards the atleast one applicator.
 122. The device of claim 121, wherein the transferelement creates a pressure differential relative to an interior of thereservoir to transfer the amount.
 123. The device of claim 120, whereinthe input is an actuator configured to simultaneously activate the pumpof the dispensing mechanism and the application mechanism.
 124. Thedevice of claim 123, wherein the dispensing mechanism further comprisesa motor.
 125. The device of claim 124, wherein the actuator activatesthe motor.
 126. The device of claim 125, further comprising a removablecover positioned over the dispensing aperture.
 127. The device of claim126, wherein the actuator opens the cover exposing the dispensingaperture.
 128. The device of claim 126, further comprising one or moregrippers configured to engage the wipes during dispensing.
 129. Thedevice of claim 128, wherein the actuator activates the one or moregrippers.
 130. The device of claim 128, wherein the actuator activatesone or more of the transfer element, the at least one applicator, themotor, the cover, and the grippers simultaneously.
 131. The device ofclaim 120, wherein the pump of the transfer element is powered by anelectric motor upon actuation of the input to create a pressuredifferential relative to the interior volume of the reservoir.
 132. Thedevice of claim 131, wherein the pump is a positive displacement pump,reciprocating pump, rotary pump, piston pump, diaphragm pump,peristaltic pump, dynamic pump, centrifugal pump, or hydraulic pump.133. The device of claim 120, wherein the at least one applicator isconfigured to apply the amount of first and second composition to thewipe by directly contacting the wipe.
 134. The device of claim 112,wherein the application mechanism provides for one-sided or two-sidedapplication of the amount of the first, second, and third compositionsto the wipe.
 135. The device of claim 70, wherein the reservoir furthercomprises one or more additional chambers.
 136. The device of claim 118,wherein the acidic agent or acidifying agent is selected from citricacid, benzoic acid, acetic acid, hydrochloric acid, sulfuric acid,nitric acid, hydrofluoric acid, hydrobromic acid, perchloric acid,chloric acid, hydroiodic acid, sulfurous acid, methanoic acid,phosphoric acid, nitrous acid, benzenesulfonic acid, metaperiodic acid,ascorbic acid, trimethoxybenzoic acid, peracetic acid, oxalic acid,formic acid, glucaric acid, gluconic acid, tartaric acid, lactic acid,boric acid, carbonic acid, acrylic acid, phenylsuccinic acid, succinicacid, propanoic acid, and acidic buffers within the range of pH 0-7comprised of said acids and their necessary conjugate bases as well asoptional stabilizing salts.
 137. The device of claim 119, wherein thesurfactant, if present, comprises one or more sodium xylene sulfonate,disodium decyl phenyl ether disulfonate, disodiumoxybis[decylbenzenesulfonate].
 138. The device of claim 118, wherein thecolorant is selected from indigo carmine, Acid Blue 1, Direct Blue 1, orFD&C Blue
 1. 139. The device of claim 118, wherein the corrosioninhibitor is sodium carbonate.